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The Roles of Adipose Tissue Macrophages in Human Disease

Macrophages are a population of immune cells functioning in antigen presentation and inflammatory response. Research has demonstrated that macrophages belong to a cell lineage with strong plasticity and heterogeneity and can be polarized into different phenotypes under different microenvironments or...

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Autores principales: Liang, Weizheng, Qi, Yanxu, Yi, Hongyang, Mao, Chenyu, Meng, Qingxue, Wang, Hao, Zheng, Chunfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222901/
https://www.ncbi.nlm.nih.gov/pubmed/35757707
http://dx.doi.org/10.3389/fimmu.2022.908749
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author Liang, Weizheng
Qi, Yanxu
Yi, Hongyang
Mao, Chenyu
Meng, Qingxue
Wang, Hao
Zheng, Chunfu
author_facet Liang, Weizheng
Qi, Yanxu
Yi, Hongyang
Mao, Chenyu
Meng, Qingxue
Wang, Hao
Zheng, Chunfu
author_sort Liang, Weizheng
collection PubMed
description Macrophages are a population of immune cells functioning in antigen presentation and inflammatory response. Research has demonstrated that macrophages belong to a cell lineage with strong plasticity and heterogeneity and can be polarized into different phenotypes under different microenvironments or stimuli. Many macrophages can be recruited by various cytokines secreted by adipose tissue. The recruited macrophages further secrete various inflammatory factors to act on adipocytes, and the interaction between the two leads to chronic inflammation. Previous studies have indicated that adipose tissue macrophages (ATMs) are closely related to metabolic diseases like obesity and diabetes. Here, we will not only conclude the current progress of factors affecting the polarization of adipose tissue macrophages but also elucidate the relationship between ATMs and human diseases. Furthermore, we will highlight its potential in preventing and treating metabolic diseases as immunotherapy targets.
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spelling pubmed-92229012022-06-24 The Roles of Adipose Tissue Macrophages in Human Disease Liang, Weizheng Qi, Yanxu Yi, Hongyang Mao, Chenyu Meng, Qingxue Wang, Hao Zheng, Chunfu Front Immunol Immunology Macrophages are a population of immune cells functioning in antigen presentation and inflammatory response. Research has demonstrated that macrophages belong to a cell lineage with strong plasticity and heterogeneity and can be polarized into different phenotypes under different microenvironments or stimuli. Many macrophages can be recruited by various cytokines secreted by adipose tissue. The recruited macrophages further secrete various inflammatory factors to act on adipocytes, and the interaction between the two leads to chronic inflammation. Previous studies have indicated that adipose tissue macrophages (ATMs) are closely related to metabolic diseases like obesity and diabetes. Here, we will not only conclude the current progress of factors affecting the polarization of adipose tissue macrophages but also elucidate the relationship between ATMs and human diseases. Furthermore, we will highlight its potential in preventing and treating metabolic diseases as immunotherapy targets. Frontiers Media S.A. 2022-06-09 /pmc/articles/PMC9222901/ /pubmed/35757707 http://dx.doi.org/10.3389/fimmu.2022.908749 Text en Copyright © 2022 Liang, Qi, Yi, Mao, Meng, Wang and Zheng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Liang, Weizheng
Qi, Yanxu
Yi, Hongyang
Mao, Chenyu
Meng, Qingxue
Wang, Hao
Zheng, Chunfu
The Roles of Adipose Tissue Macrophages in Human Disease
title The Roles of Adipose Tissue Macrophages in Human Disease
title_full The Roles of Adipose Tissue Macrophages in Human Disease
title_fullStr The Roles of Adipose Tissue Macrophages in Human Disease
title_full_unstemmed The Roles of Adipose Tissue Macrophages in Human Disease
title_short The Roles of Adipose Tissue Macrophages in Human Disease
title_sort roles of adipose tissue macrophages in human disease
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222901/
https://www.ncbi.nlm.nih.gov/pubmed/35757707
http://dx.doi.org/10.3389/fimmu.2022.908749
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