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Acute Supplementation with Cannabidiol Does Not Attenuate Inflammation or Improve Measures of Performance following Strenuous Exercise

Supplementation with cannabidiol (CBD) may expedite recovery when consumed after exercise. The purpose of this study was to determine if supplementation with CBD reduces inflammation and enhances performance following strenuous eccentric exercise in collegiate athletes. Twenty-four well-trained fema...

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Autores principales: Crossland, Brett W., Rigby, B. Rhett, Duplanty, Anthony A., King, George A., Juma, Shanil, Levine, Nicholas A., Clark, Cayla E., Ramirez, Kyndall P., Varone, Nicole L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222918/
https://www.ncbi.nlm.nih.gov/pubmed/35742183
http://dx.doi.org/10.3390/healthcare10061133
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author Crossland, Brett W.
Rigby, B. Rhett
Duplanty, Anthony A.
King, George A.
Juma, Shanil
Levine, Nicholas A.
Clark, Cayla E.
Ramirez, Kyndall P.
Varone, Nicole L.
author_facet Crossland, Brett W.
Rigby, B. Rhett
Duplanty, Anthony A.
King, George A.
Juma, Shanil
Levine, Nicholas A.
Clark, Cayla E.
Ramirez, Kyndall P.
Varone, Nicole L.
author_sort Crossland, Brett W.
collection PubMed
description Supplementation with cannabidiol (CBD) may expedite recovery when consumed after exercise. The purpose of this study was to determine if supplementation with CBD reduces inflammation and enhances performance following strenuous eccentric exercise in collegiate athletes. Twenty-four well-trained females (age = 21.2 ± 1.8 years, height = 166.4 ± 8 cm, weight = 64.9 ± 9.1 kg) completed 100 repetitions of unilateral eccentric leg extension to induce muscle damage. In this crossover design, participants were randomized to receive 5 mg/kg of CBD in pill form or a placebo 2 h prior to, immediately following, and 10 h following muscle damage. Blood was collected, and performance and fatigue were measured prior to, and 4 h, 24 h, and 48 h following the muscle damage. Approximately 28 days separated treatment administration to control for the menstrual cycle. No significant differences were observed between the treatments for inflammation, muscle damage, or subjective fatigue. Peak torque at 60°/s (p = 0.001) and peak isometric torque (p = 0.02) were significantly lower 24 h following muscle damage, but no difference in performance was observed between treatments at any timepoint. Cannabidiol supplementation was unable to reduce fatigue, limit inflammation, or restore performance in well-trained female athletes.
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spelling pubmed-92229182022-06-24 Acute Supplementation with Cannabidiol Does Not Attenuate Inflammation or Improve Measures of Performance following Strenuous Exercise Crossland, Brett W. Rigby, B. Rhett Duplanty, Anthony A. King, George A. Juma, Shanil Levine, Nicholas A. Clark, Cayla E. Ramirez, Kyndall P. Varone, Nicole L. Healthcare (Basel) Article Supplementation with cannabidiol (CBD) may expedite recovery when consumed after exercise. The purpose of this study was to determine if supplementation with CBD reduces inflammation and enhances performance following strenuous eccentric exercise in collegiate athletes. Twenty-four well-trained females (age = 21.2 ± 1.8 years, height = 166.4 ± 8 cm, weight = 64.9 ± 9.1 kg) completed 100 repetitions of unilateral eccentric leg extension to induce muscle damage. In this crossover design, participants were randomized to receive 5 mg/kg of CBD in pill form or a placebo 2 h prior to, immediately following, and 10 h following muscle damage. Blood was collected, and performance and fatigue were measured prior to, and 4 h, 24 h, and 48 h following the muscle damage. Approximately 28 days separated treatment administration to control for the menstrual cycle. No significant differences were observed between the treatments for inflammation, muscle damage, or subjective fatigue. Peak torque at 60°/s (p = 0.001) and peak isometric torque (p = 0.02) were significantly lower 24 h following muscle damage, but no difference in performance was observed between treatments at any timepoint. Cannabidiol supplementation was unable to reduce fatigue, limit inflammation, or restore performance in well-trained female athletes. MDPI 2022-06-17 /pmc/articles/PMC9222918/ /pubmed/35742183 http://dx.doi.org/10.3390/healthcare10061133 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Crossland, Brett W.
Rigby, B. Rhett
Duplanty, Anthony A.
King, George A.
Juma, Shanil
Levine, Nicholas A.
Clark, Cayla E.
Ramirez, Kyndall P.
Varone, Nicole L.
Acute Supplementation with Cannabidiol Does Not Attenuate Inflammation or Improve Measures of Performance following Strenuous Exercise
title Acute Supplementation with Cannabidiol Does Not Attenuate Inflammation or Improve Measures of Performance following Strenuous Exercise
title_full Acute Supplementation with Cannabidiol Does Not Attenuate Inflammation or Improve Measures of Performance following Strenuous Exercise
title_fullStr Acute Supplementation with Cannabidiol Does Not Attenuate Inflammation or Improve Measures of Performance following Strenuous Exercise
title_full_unstemmed Acute Supplementation with Cannabidiol Does Not Attenuate Inflammation or Improve Measures of Performance following Strenuous Exercise
title_short Acute Supplementation with Cannabidiol Does Not Attenuate Inflammation or Improve Measures of Performance following Strenuous Exercise
title_sort acute supplementation with cannabidiol does not attenuate inflammation or improve measures of performance following strenuous exercise
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222918/
https://www.ncbi.nlm.nih.gov/pubmed/35742183
http://dx.doi.org/10.3390/healthcare10061133
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