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Psychosis in Parkinson’s Disease: A Lesson from Genetics

Psychosis in Parkinson’s disease (PDP) represents a common and debilitating condition that complicates Parkinson’s disease (PD), mainly in the later stages. The spectrum of psychotic symptoms are heterogeneous, ranging from minor phenomena of mild illusions, passage hallucinations and sense of prese...

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Autores principales: Angelopoulou, Efthalia, Bougea, Anastasia, Papageorgiou, Sokratis G., Villa, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222985/
https://www.ncbi.nlm.nih.gov/pubmed/35741861
http://dx.doi.org/10.3390/genes13061099
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author Angelopoulou, Efthalia
Bougea, Anastasia
Papageorgiou, Sokratis G.
Villa, Chiara
author_facet Angelopoulou, Efthalia
Bougea, Anastasia
Papageorgiou, Sokratis G.
Villa, Chiara
author_sort Angelopoulou, Efthalia
collection PubMed
description Psychosis in Parkinson’s disease (PDP) represents a common and debilitating condition that complicates Parkinson’s disease (PD), mainly in the later stages. The spectrum of psychotic symptoms are heterogeneous, ranging from minor phenomena of mild illusions, passage hallucinations and sense of presence to severe psychosis consisting of visual hallucinations (and rarely, auditory and tactile or gustatory) and paranoid delusions. PDP is associated with increased caregiver stress, poorer quality of life for patients and carers, reduced survival and risk of institutionalization with a significant burden on the healthcare system. Although several risk factors for PDP development have been identified, such as aging, sleep disturbances, long history of PD, cognitive impairment, depression and visual disorders, the pathophysiology of psychosis in PD is complex and still insufficiently clarified. Additionally, several drugs used to treat PD can aggravate or even precipitate PDP. Herein, we reviewed and critically analyzed recent studies exploring the genetic architecture of psychosis in PD in order to further understand the pathophysiology of PDP, the risk factors as well as the most suitable therapeutic strategies.
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spelling pubmed-92229852022-06-24 Psychosis in Parkinson’s Disease: A Lesson from Genetics Angelopoulou, Efthalia Bougea, Anastasia Papageorgiou, Sokratis G. Villa, Chiara Genes (Basel) Review Psychosis in Parkinson’s disease (PDP) represents a common and debilitating condition that complicates Parkinson’s disease (PD), mainly in the later stages. The spectrum of psychotic symptoms are heterogeneous, ranging from minor phenomena of mild illusions, passage hallucinations and sense of presence to severe psychosis consisting of visual hallucinations (and rarely, auditory and tactile or gustatory) and paranoid delusions. PDP is associated with increased caregiver stress, poorer quality of life for patients and carers, reduced survival and risk of institutionalization with a significant burden on the healthcare system. Although several risk factors for PDP development have been identified, such as aging, sleep disturbances, long history of PD, cognitive impairment, depression and visual disorders, the pathophysiology of psychosis in PD is complex and still insufficiently clarified. Additionally, several drugs used to treat PD can aggravate or even precipitate PDP. Herein, we reviewed and critically analyzed recent studies exploring the genetic architecture of psychosis in PD in order to further understand the pathophysiology of PDP, the risk factors as well as the most suitable therapeutic strategies. MDPI 2022-06-20 /pmc/articles/PMC9222985/ /pubmed/35741861 http://dx.doi.org/10.3390/genes13061099 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Angelopoulou, Efthalia
Bougea, Anastasia
Papageorgiou, Sokratis G.
Villa, Chiara
Psychosis in Parkinson’s Disease: A Lesson from Genetics
title Psychosis in Parkinson’s Disease: A Lesson from Genetics
title_full Psychosis in Parkinson’s Disease: A Lesson from Genetics
title_fullStr Psychosis in Parkinson’s Disease: A Lesson from Genetics
title_full_unstemmed Psychosis in Parkinson’s Disease: A Lesson from Genetics
title_short Psychosis in Parkinson’s Disease: A Lesson from Genetics
title_sort psychosis in parkinson’s disease: a lesson from genetics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222985/
https://www.ncbi.nlm.nih.gov/pubmed/35741861
http://dx.doi.org/10.3390/genes13061099
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