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Genetics and Sport Injuries: New Perspectives for Athletic Excellence in an Italian Court of Rugby Union Players
Several genes are involved in sport performance, especially in injuries incidence. The aim of this study was to investigate the association of ACE, ACTN3, COL1A1, and MCT1 genotypes and injuries in rugby players in order to find a genotype/phenotype correlation and provide useful information improvi...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223017/ https://www.ncbi.nlm.nih.gov/pubmed/35741757 http://dx.doi.org/10.3390/genes13060995 |
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author | Onori, Maria Elisabetta Pasqualetti, Massimo Moretti, Giacomo Canu, Giulia De Paolis, Giulio Baroni, Silvia Minucci, Angelo Galvani, Christel Urbani, Andrea |
author_facet | Onori, Maria Elisabetta Pasqualetti, Massimo Moretti, Giacomo Canu, Giulia De Paolis, Giulio Baroni, Silvia Minucci, Angelo Galvani, Christel Urbani, Andrea |
author_sort | Onori, Maria Elisabetta |
collection | PubMed |
description | Several genes are involved in sport performance, especially in injuries incidence. The aim of this study was to investigate the association of ACE, ACTN3, COL1A1, and MCT1 genotypes and injuries in rugby players in order to find a genotype/phenotype correlation and provide useful information improving athletic performance. One-hundred male professional and semiprofessional rugby players were selected. Analysis was performed genotyping the genes ACE, ACTN3, COL1A1, and MCT1 as candidate gene of interest involved in athletic performance. A control group of non-athletic Italian male participants was analyzed to compare the results. We found statistical significance of MCT1 rs1049434 AA for total injuries (χ(2) = 0.115; p = 0.003) and bone injuries (χ(2) = 0.603; p = 0.007) in the rugby athlete population. No statistical significance was found between injury incidence and ACE, ACTN3, COL1A1 genotypes. The MCT1 AA genotype is associated with the incidence of total and bone injuries in the rugby player population. Although environmental factors such as lifestyle, diet, training, and stress can influence athletic performance, our data demonstrated the importance of genetic study in sport aimed at developing personalized training and achieving the best possible athletic excellence. |
format | Online Article Text |
id | pubmed-9223017 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92230172022-06-24 Genetics and Sport Injuries: New Perspectives for Athletic Excellence in an Italian Court of Rugby Union Players Onori, Maria Elisabetta Pasqualetti, Massimo Moretti, Giacomo Canu, Giulia De Paolis, Giulio Baroni, Silvia Minucci, Angelo Galvani, Christel Urbani, Andrea Genes (Basel) Article Several genes are involved in sport performance, especially in injuries incidence. The aim of this study was to investigate the association of ACE, ACTN3, COL1A1, and MCT1 genotypes and injuries in rugby players in order to find a genotype/phenotype correlation and provide useful information improving athletic performance. One-hundred male professional and semiprofessional rugby players were selected. Analysis was performed genotyping the genes ACE, ACTN3, COL1A1, and MCT1 as candidate gene of interest involved in athletic performance. A control group of non-athletic Italian male participants was analyzed to compare the results. We found statistical significance of MCT1 rs1049434 AA for total injuries (χ(2) = 0.115; p = 0.003) and bone injuries (χ(2) = 0.603; p = 0.007) in the rugby athlete population. No statistical significance was found between injury incidence and ACE, ACTN3, COL1A1 genotypes. The MCT1 AA genotype is associated with the incidence of total and bone injuries in the rugby player population. Although environmental factors such as lifestyle, diet, training, and stress can influence athletic performance, our data demonstrated the importance of genetic study in sport aimed at developing personalized training and achieving the best possible athletic excellence. MDPI 2022-06-01 /pmc/articles/PMC9223017/ /pubmed/35741757 http://dx.doi.org/10.3390/genes13060995 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Onori, Maria Elisabetta Pasqualetti, Massimo Moretti, Giacomo Canu, Giulia De Paolis, Giulio Baroni, Silvia Minucci, Angelo Galvani, Christel Urbani, Andrea Genetics and Sport Injuries: New Perspectives for Athletic Excellence in an Italian Court of Rugby Union Players |
title | Genetics and Sport Injuries: New Perspectives for Athletic Excellence in an Italian Court of Rugby Union Players |
title_full | Genetics and Sport Injuries: New Perspectives for Athletic Excellence in an Italian Court of Rugby Union Players |
title_fullStr | Genetics and Sport Injuries: New Perspectives for Athletic Excellence in an Italian Court of Rugby Union Players |
title_full_unstemmed | Genetics and Sport Injuries: New Perspectives for Athletic Excellence in an Italian Court of Rugby Union Players |
title_short | Genetics and Sport Injuries: New Perspectives for Athletic Excellence in an Italian Court of Rugby Union Players |
title_sort | genetics and sport injuries: new perspectives for athletic excellence in an italian court of rugby union players |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223017/ https://www.ncbi.nlm.nih.gov/pubmed/35741757 http://dx.doi.org/10.3390/genes13060995 |
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