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Higher Lead and Lower Calcium Levels Are Associated with Increased Risk of Mortality in Malaysian Older Population: Findings from the LRGS-TUA Longitudinal Study

The main objective of this study is to determine the association of various trace elements’ status with the 5-year mortality rate among community-dwelling older adults in Malaysia. This study was part of the Long-term Research Grant Scheme—Towards Useful Ageing (LRGS-TUA). The participants were foll...

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Autores principales: Ooi, Theng Choon, Singh, Devinder Kaur Ajit, Shahar, Suzana, Sharif, Razinah, Rivan, Nurul Fatin Malek, Meramat, Asheila, Rajab, Nor Fadilah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223054/
https://www.ncbi.nlm.nih.gov/pubmed/35742205
http://dx.doi.org/10.3390/ijerph19126955
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author Ooi, Theng Choon
Singh, Devinder Kaur Ajit
Shahar, Suzana
Sharif, Razinah
Rivan, Nurul Fatin Malek
Meramat, Asheila
Rajab, Nor Fadilah
author_facet Ooi, Theng Choon
Singh, Devinder Kaur Ajit
Shahar, Suzana
Sharif, Razinah
Rivan, Nurul Fatin Malek
Meramat, Asheila
Rajab, Nor Fadilah
author_sort Ooi, Theng Choon
collection PubMed
description The main objective of this study is to determine the association of various trace elements’ status with the 5-year mortality rate among community-dwelling older adults in Malaysia. This study was part of the Long-term Research Grant Scheme—Towards Useful Ageing (LRGS-TUA). The participants were followed up for five years, and their mortality status was identified through the Mortality Data Matching Service provided by the National Registration Department, Malaysia. Of the 303 participants included in this study, 34 (11.2%) participants had died within five years after baseline data collection. As compared to the survivors, participants who died earlier were more likely (p < 0.05) to be men, smokers, have a lower intake of total dietary fiber and molybdenum, higher intake of manganese, lower zinc levels in toenail samples, lower calcium and higher lead levels in hair samples during baseline. Following the multivariate Cox proportional hazard analysis, lower total dietary fiber intake (HR: 0.681; 0.532–0.871), lower calcium (HR: 0.999; 95% CI: 0.999–1.000) and higher lead (HR: 1.309; 95% CI: 1.061–1.616) levels in hair samples appeared as the predictors of mortality. In conclusion, higher lead and lower calcium levels are associated with higher risk of mortality among community-dwelling older adults in Malaysia. Our current findings provide a better understanding of how the trace elements’ status may affect older populations’ well-being and mortality rate.
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spelling pubmed-92230542022-06-24 Higher Lead and Lower Calcium Levels Are Associated with Increased Risk of Mortality in Malaysian Older Population: Findings from the LRGS-TUA Longitudinal Study Ooi, Theng Choon Singh, Devinder Kaur Ajit Shahar, Suzana Sharif, Razinah Rivan, Nurul Fatin Malek Meramat, Asheila Rajab, Nor Fadilah Int J Environ Res Public Health Article The main objective of this study is to determine the association of various trace elements’ status with the 5-year mortality rate among community-dwelling older adults in Malaysia. This study was part of the Long-term Research Grant Scheme—Towards Useful Ageing (LRGS-TUA). The participants were followed up for five years, and their mortality status was identified through the Mortality Data Matching Service provided by the National Registration Department, Malaysia. Of the 303 participants included in this study, 34 (11.2%) participants had died within five years after baseline data collection. As compared to the survivors, participants who died earlier were more likely (p < 0.05) to be men, smokers, have a lower intake of total dietary fiber and molybdenum, higher intake of manganese, lower zinc levels in toenail samples, lower calcium and higher lead levels in hair samples during baseline. Following the multivariate Cox proportional hazard analysis, lower total dietary fiber intake (HR: 0.681; 0.532–0.871), lower calcium (HR: 0.999; 95% CI: 0.999–1.000) and higher lead (HR: 1.309; 95% CI: 1.061–1.616) levels in hair samples appeared as the predictors of mortality. In conclusion, higher lead and lower calcium levels are associated with higher risk of mortality among community-dwelling older adults in Malaysia. Our current findings provide a better understanding of how the trace elements’ status may affect older populations’ well-being and mortality rate. MDPI 2022-06-07 /pmc/articles/PMC9223054/ /pubmed/35742205 http://dx.doi.org/10.3390/ijerph19126955 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ooi, Theng Choon
Singh, Devinder Kaur Ajit
Shahar, Suzana
Sharif, Razinah
Rivan, Nurul Fatin Malek
Meramat, Asheila
Rajab, Nor Fadilah
Higher Lead and Lower Calcium Levels Are Associated with Increased Risk of Mortality in Malaysian Older Population: Findings from the LRGS-TUA Longitudinal Study
title Higher Lead and Lower Calcium Levels Are Associated with Increased Risk of Mortality in Malaysian Older Population: Findings from the LRGS-TUA Longitudinal Study
title_full Higher Lead and Lower Calcium Levels Are Associated with Increased Risk of Mortality in Malaysian Older Population: Findings from the LRGS-TUA Longitudinal Study
title_fullStr Higher Lead and Lower Calcium Levels Are Associated with Increased Risk of Mortality in Malaysian Older Population: Findings from the LRGS-TUA Longitudinal Study
title_full_unstemmed Higher Lead and Lower Calcium Levels Are Associated with Increased Risk of Mortality in Malaysian Older Population: Findings from the LRGS-TUA Longitudinal Study
title_short Higher Lead and Lower Calcium Levels Are Associated with Increased Risk of Mortality in Malaysian Older Population: Findings from the LRGS-TUA Longitudinal Study
title_sort higher lead and lower calcium levels are associated with increased risk of mortality in malaysian older population: findings from the lrgs-tua longitudinal study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223054/
https://www.ncbi.nlm.nih.gov/pubmed/35742205
http://dx.doi.org/10.3390/ijerph19126955
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