Cargando…

Dengue Seroprevalence and Factors Associated with Dengue Seropositivity in Petaling District, Malaysia

Dengue virus (DENV) infection is a major public health concern, posing huge economic and disease burdens globally. In Malaysia, the incidence of DENV infections has increased significantly over the years. Nevertheless, the passive surveillance mechanism applied may not capture the actual magnitude o...

Descripción completa

Detalles Bibliográficos
Autores principales: Ng, Rui Jie, Chong, Zhuo Lin, Abdul Mutalip, Mohd Hatta, Ng, Chiu-Wan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223214/
https://www.ncbi.nlm.nih.gov/pubmed/35742419
http://dx.doi.org/10.3390/ijerph19127170
_version_ 1784733071389491200
author Ng, Rui Jie
Chong, Zhuo Lin
Abdul Mutalip, Mohd Hatta
Ng, Chiu-Wan
author_facet Ng, Rui Jie
Chong, Zhuo Lin
Abdul Mutalip, Mohd Hatta
Ng, Chiu-Wan
author_sort Ng, Rui Jie
collection PubMed
description Dengue virus (DENV) infection is a major public health concern, posing huge economic and disease burdens globally. In Malaysia, the incidence of DENV infections has increased significantly over the years. Nevertheless, the passive surveillance mechanism applied may not capture the actual magnitude of DENV infection. There was also a paucity of community-based studies exploring DENV seroprevalence. This study aimed to determine the DENV seroprevalence and the associated factors among the urban population in Petaling district, Malaysia. A population-based cross-sectional study was conducted from 18 August to 26 October 2018 with 533 participants recruited. Blood samples were collected and analysed for DENV seropositivity using a composite reference standard comprised of three dengue serological tests. Associated factors were identified by fitting Generalised Linear Mixed Models with binomial error structure and logit link function. DENV seroprevalence obtained was 79.0% (95% CI: 75.2–82.4%). The age-specific DENV seroprevalence showed an increasing trend with advancing age, from 22.7% (95% CI: 9.6–45.0%) for those aged below five years old to 94.9% (95% CI: 81.3–98.7%) for those aged ≥60 years old. Only age group and house level were found to be significant factors associated with DENV seropositivity. The odds of being DENV seropositive generally increased with age, from 13.43 (95% CI: 2.77–65.22) for the 5–9 years old age group to 384.77 (95% CI: 39.27–3769.97) for the ≥60 years old age group, as compared to those aged below 5 years old. For house level, those who lived on the first and second floor (OR: 8.98, 95% CI: 3.16–25.12) and the third floor and above (OR: 4.82, 95% CI: 1.89–12.32) had greater odds of being DENV seropositive compared to those living on the ground floor. This study demonstrated the persistently high DENV seroprevalence among the urban population in Petaling district, which could be useful to evaluate dengue control measures taken and estimate more accurate disease incidence. The associated factors with DENV seropositivity identified could also contribute to undertaking more targeted preventive and control measures.
format Online
Article
Text
id pubmed-9223214
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-92232142022-06-24 Dengue Seroprevalence and Factors Associated with Dengue Seropositivity in Petaling District, Malaysia Ng, Rui Jie Chong, Zhuo Lin Abdul Mutalip, Mohd Hatta Ng, Chiu-Wan Int J Environ Res Public Health Article Dengue virus (DENV) infection is a major public health concern, posing huge economic and disease burdens globally. In Malaysia, the incidence of DENV infections has increased significantly over the years. Nevertheless, the passive surveillance mechanism applied may not capture the actual magnitude of DENV infection. There was also a paucity of community-based studies exploring DENV seroprevalence. This study aimed to determine the DENV seroprevalence and the associated factors among the urban population in Petaling district, Malaysia. A population-based cross-sectional study was conducted from 18 August to 26 October 2018 with 533 participants recruited. Blood samples were collected and analysed for DENV seropositivity using a composite reference standard comprised of three dengue serological tests. Associated factors were identified by fitting Generalised Linear Mixed Models with binomial error structure and logit link function. DENV seroprevalence obtained was 79.0% (95% CI: 75.2–82.4%). The age-specific DENV seroprevalence showed an increasing trend with advancing age, from 22.7% (95% CI: 9.6–45.0%) for those aged below five years old to 94.9% (95% CI: 81.3–98.7%) for those aged ≥60 years old. Only age group and house level were found to be significant factors associated with DENV seropositivity. The odds of being DENV seropositive generally increased with age, from 13.43 (95% CI: 2.77–65.22) for the 5–9 years old age group to 384.77 (95% CI: 39.27–3769.97) for the ≥60 years old age group, as compared to those aged below 5 years old. For house level, those who lived on the first and second floor (OR: 8.98, 95% CI: 3.16–25.12) and the third floor and above (OR: 4.82, 95% CI: 1.89–12.32) had greater odds of being DENV seropositive compared to those living on the ground floor. This study demonstrated the persistently high DENV seroprevalence among the urban population in Petaling district, which could be useful to evaluate dengue control measures taken and estimate more accurate disease incidence. The associated factors with DENV seropositivity identified could also contribute to undertaking more targeted preventive and control measures. MDPI 2022-06-11 /pmc/articles/PMC9223214/ /pubmed/35742419 http://dx.doi.org/10.3390/ijerph19127170 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ng, Rui Jie
Chong, Zhuo Lin
Abdul Mutalip, Mohd Hatta
Ng, Chiu-Wan
Dengue Seroprevalence and Factors Associated with Dengue Seropositivity in Petaling District, Malaysia
title Dengue Seroprevalence and Factors Associated with Dengue Seropositivity in Petaling District, Malaysia
title_full Dengue Seroprevalence and Factors Associated with Dengue Seropositivity in Petaling District, Malaysia
title_fullStr Dengue Seroprevalence and Factors Associated with Dengue Seropositivity in Petaling District, Malaysia
title_full_unstemmed Dengue Seroprevalence and Factors Associated with Dengue Seropositivity in Petaling District, Malaysia
title_short Dengue Seroprevalence and Factors Associated with Dengue Seropositivity in Petaling District, Malaysia
title_sort dengue seroprevalence and factors associated with dengue seropositivity in petaling district, malaysia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223214/
https://www.ncbi.nlm.nih.gov/pubmed/35742419
http://dx.doi.org/10.3390/ijerph19127170
work_keys_str_mv AT ngruijie dengueseroprevalenceandfactorsassociatedwithdengueseropositivityinpetalingdistrictmalaysia
AT chongzhuolin dengueseroprevalenceandfactorsassociatedwithdengueseropositivityinpetalingdistrictmalaysia
AT abdulmutalipmohdhatta dengueseroprevalenceandfactorsassociatedwithdengueseropositivityinpetalingdistrictmalaysia
AT ngchiuwan dengueseroprevalenceandfactorsassociatedwithdengueseropositivityinpetalingdistrictmalaysia