Cargando…

Genetic Expression between Ageing and Exercise: Secreted Protein Acidic and Rich in Cysteine as a Potential “Exercise Substitute” Antiageing Therapy

Ageing is the effect of time on biological entities. It represents a risk factor for a variety of diseases and health disorders; thus, therapeutic options are required to tackle ageing issues. Modern geriatric medicine prescribes exercise to counteract ageing effects. This work presents secreted pro...

Descripción completa

Detalles Bibliográficos
Autores principales: Ghanemi, Abdelaziz, Yoshioka, Mayumi, St-Amand, Jonny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223223/
https://www.ncbi.nlm.nih.gov/pubmed/35741712
http://dx.doi.org/10.3390/genes13060950
_version_ 1784733073724669952
author Ghanemi, Abdelaziz
Yoshioka, Mayumi
St-Amand, Jonny
author_facet Ghanemi, Abdelaziz
Yoshioka, Mayumi
St-Amand, Jonny
author_sort Ghanemi, Abdelaziz
collection PubMed
description Ageing is the effect of time on biological entities. It represents a risk factor for a variety of diseases and health disorders; thus, therapeutic options are required to tackle ageing issues. Modern geriatric medicine prescribes exercise to counteract ageing effects. This work presents secreted protein acidic and rich in cysteine (SPARC) as a potential antiageing therapy. Indeed, SPARC declines with ageing, exercise induces SPARC, and SPARC overexpression in mice mimics exercise. Thus, we hypothesize that SPARC is an exercise-induced factor that is beyond—at least part of—the antiageing effects induced by exercise. This could become a potential antiageing therapy for the elderly that counteracts ageing by mimicking the effects of exercise without needing to perform exercise. This is of particular importance because ageing usually reduces mobility and age-related diseases can reduce the ability to perform the required physical activity. On the other hand, the possibilities of mimicking exercise benefits via SPARC are not limited to ageing, and can be applied in various contexts in which exercise cannot be performed because of physical disabilities, health disorders, or limited mobility.
format Online
Article
Text
id pubmed-9223223
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-92232232022-06-24 Genetic Expression between Ageing and Exercise: Secreted Protein Acidic and Rich in Cysteine as a Potential “Exercise Substitute” Antiageing Therapy Ghanemi, Abdelaziz Yoshioka, Mayumi St-Amand, Jonny Genes (Basel) Opinion Ageing is the effect of time on biological entities. It represents a risk factor for a variety of diseases and health disorders; thus, therapeutic options are required to tackle ageing issues. Modern geriatric medicine prescribes exercise to counteract ageing effects. This work presents secreted protein acidic and rich in cysteine (SPARC) as a potential antiageing therapy. Indeed, SPARC declines with ageing, exercise induces SPARC, and SPARC overexpression in mice mimics exercise. Thus, we hypothesize that SPARC is an exercise-induced factor that is beyond—at least part of—the antiageing effects induced by exercise. This could become a potential antiageing therapy for the elderly that counteracts ageing by mimicking the effects of exercise without needing to perform exercise. This is of particular importance because ageing usually reduces mobility and age-related diseases can reduce the ability to perform the required physical activity. On the other hand, the possibilities of mimicking exercise benefits via SPARC are not limited to ageing, and can be applied in various contexts in which exercise cannot be performed because of physical disabilities, health disorders, or limited mobility. MDPI 2022-05-26 /pmc/articles/PMC9223223/ /pubmed/35741712 http://dx.doi.org/10.3390/genes13060950 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Opinion
Ghanemi, Abdelaziz
Yoshioka, Mayumi
St-Amand, Jonny
Genetic Expression between Ageing and Exercise: Secreted Protein Acidic and Rich in Cysteine as a Potential “Exercise Substitute” Antiageing Therapy
title Genetic Expression between Ageing and Exercise: Secreted Protein Acidic and Rich in Cysteine as a Potential “Exercise Substitute” Antiageing Therapy
title_full Genetic Expression between Ageing and Exercise: Secreted Protein Acidic and Rich in Cysteine as a Potential “Exercise Substitute” Antiageing Therapy
title_fullStr Genetic Expression between Ageing and Exercise: Secreted Protein Acidic and Rich in Cysteine as a Potential “Exercise Substitute” Antiageing Therapy
title_full_unstemmed Genetic Expression between Ageing and Exercise: Secreted Protein Acidic and Rich in Cysteine as a Potential “Exercise Substitute” Antiageing Therapy
title_short Genetic Expression between Ageing and Exercise: Secreted Protein Acidic and Rich in Cysteine as a Potential “Exercise Substitute” Antiageing Therapy
title_sort genetic expression between ageing and exercise: secreted protein acidic and rich in cysteine as a potential “exercise substitute” antiageing therapy
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223223/
https://www.ncbi.nlm.nih.gov/pubmed/35741712
http://dx.doi.org/10.3390/genes13060950
work_keys_str_mv AT ghanemiabdelaziz geneticexpressionbetweenageingandexercisesecretedproteinacidicandrichincysteineasapotentialexercisesubstituteantiageingtherapy
AT yoshiokamayumi geneticexpressionbetweenageingandexercisesecretedproteinacidicandrichincysteineasapotentialexercisesubstituteantiageingtherapy
AT stamandjonny geneticexpressionbetweenageingandexercisesecretedproteinacidicandrichincysteineasapotentialexercisesubstituteantiageingtherapy