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Old and New Systemic Immune-Inflammation Indexes Are Associated with Overall Survival of Glioblastoma Patients Treated with Radio-Chemotherapy

Background. Systemic immunity and inflammation indexes (SI) derived from blood cells have gained increasing attention in clinical oncology as potential biomarkers that are associated with survival. Materials and methods. We tested 12 different SI using blood tests from patients with isocitrate dehyd...

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Autores principales: Pasqualetti, Francesco, Giampietro, Celeste, Montemurro, Nicola, Giannini, Noemi, Gadducci, Giovanni, Orlandi, Paola, Natali, Eleonora, Chiarugi, Paolo, Gonnelli, Alessandra, Cantarella, Martina, Scatena, Cristian, Fanelli, Giuseppe Nicolò, Naccarato, Antonio Giuseppe, Perrini, Paolo, Liberti, Gaetano, Morganti, Riccardo, Franzini, Maria, Paolicchi, Aldo, Pellegrini, Giovanni, Bocci, Guido, Paiar, Fabiola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223226/
https://www.ncbi.nlm.nih.gov/pubmed/35741816
http://dx.doi.org/10.3390/genes13061054
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author Pasqualetti, Francesco
Giampietro, Celeste
Montemurro, Nicola
Giannini, Noemi
Gadducci, Giovanni
Orlandi, Paola
Natali, Eleonora
Chiarugi, Paolo
Gonnelli, Alessandra
Cantarella, Martina
Scatena, Cristian
Fanelli, Giuseppe Nicolò
Naccarato, Antonio Giuseppe
Perrini, Paolo
Liberti, Gaetano
Morganti, Riccardo
Franzini, Maria
Paolicchi, Aldo
Pellegrini, Giovanni
Bocci, Guido
Paiar, Fabiola
author_facet Pasqualetti, Francesco
Giampietro, Celeste
Montemurro, Nicola
Giannini, Noemi
Gadducci, Giovanni
Orlandi, Paola
Natali, Eleonora
Chiarugi, Paolo
Gonnelli, Alessandra
Cantarella, Martina
Scatena, Cristian
Fanelli, Giuseppe Nicolò
Naccarato, Antonio Giuseppe
Perrini, Paolo
Liberti, Gaetano
Morganti, Riccardo
Franzini, Maria
Paolicchi, Aldo
Pellegrini, Giovanni
Bocci, Guido
Paiar, Fabiola
author_sort Pasqualetti, Francesco
collection PubMed
description Background. Systemic immunity and inflammation indexes (SI) derived from blood cells have gained increasing attention in clinical oncology as potential biomarkers that are associated with survival. Materials and methods. We tested 12 different SI using blood tests from patients with isocitrate dehydrogenase 1 and 2 wild-type glioblastomas, treated with radio-chemotherapy. The primary endpoint was their overall survival. Results. A total of 77 patients, comprising 43 males and 34 females, with a median age of 64 years (age range 26–84), who were treated between October 2010 and July 2020, were included in the present analysis (approved by a local ethics committee). In the univariate Cox regression analysis, all the indexes except two showed a statistically significant impact on OS. In the multivariate Cox regression analysis, neutrophil × platelet × leukocyte/(lymphocyte × monocyte) (NPW/LM) and neutrophil × platelet × monocyte/lymphocyte (NPM/L) maintained their statistically significant impact value. Conclusions. This univariate analysis confirms the potential of systemic inflammation indexes in patients with glioblastoma, while the multivariate analysis verifies the prognostic value of NPW/LM and NPM/L.
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spelling pubmed-92232262022-06-24 Old and New Systemic Immune-Inflammation Indexes Are Associated with Overall Survival of Glioblastoma Patients Treated with Radio-Chemotherapy Pasqualetti, Francesco Giampietro, Celeste Montemurro, Nicola Giannini, Noemi Gadducci, Giovanni Orlandi, Paola Natali, Eleonora Chiarugi, Paolo Gonnelli, Alessandra Cantarella, Martina Scatena, Cristian Fanelli, Giuseppe Nicolò Naccarato, Antonio Giuseppe Perrini, Paolo Liberti, Gaetano Morganti, Riccardo Franzini, Maria Paolicchi, Aldo Pellegrini, Giovanni Bocci, Guido Paiar, Fabiola Genes (Basel) Article Background. Systemic immunity and inflammation indexes (SI) derived from blood cells have gained increasing attention in clinical oncology as potential biomarkers that are associated with survival. Materials and methods. We tested 12 different SI using blood tests from patients with isocitrate dehydrogenase 1 and 2 wild-type glioblastomas, treated with radio-chemotherapy. The primary endpoint was their overall survival. Results. A total of 77 patients, comprising 43 males and 34 females, with a median age of 64 years (age range 26–84), who were treated between October 2010 and July 2020, were included in the present analysis (approved by a local ethics committee). In the univariate Cox regression analysis, all the indexes except two showed a statistically significant impact on OS. In the multivariate Cox regression analysis, neutrophil × platelet × leukocyte/(lymphocyte × monocyte) (NPW/LM) and neutrophil × platelet × monocyte/lymphocyte (NPM/L) maintained their statistically significant impact value. Conclusions. This univariate analysis confirms the potential of systemic inflammation indexes in patients with glioblastoma, while the multivariate analysis verifies the prognostic value of NPW/LM and NPM/L. MDPI 2022-06-13 /pmc/articles/PMC9223226/ /pubmed/35741816 http://dx.doi.org/10.3390/genes13061054 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pasqualetti, Francesco
Giampietro, Celeste
Montemurro, Nicola
Giannini, Noemi
Gadducci, Giovanni
Orlandi, Paola
Natali, Eleonora
Chiarugi, Paolo
Gonnelli, Alessandra
Cantarella, Martina
Scatena, Cristian
Fanelli, Giuseppe Nicolò
Naccarato, Antonio Giuseppe
Perrini, Paolo
Liberti, Gaetano
Morganti, Riccardo
Franzini, Maria
Paolicchi, Aldo
Pellegrini, Giovanni
Bocci, Guido
Paiar, Fabiola
Old and New Systemic Immune-Inflammation Indexes Are Associated with Overall Survival of Glioblastoma Patients Treated with Radio-Chemotherapy
title Old and New Systemic Immune-Inflammation Indexes Are Associated with Overall Survival of Glioblastoma Patients Treated with Radio-Chemotherapy
title_full Old and New Systemic Immune-Inflammation Indexes Are Associated with Overall Survival of Glioblastoma Patients Treated with Radio-Chemotherapy
title_fullStr Old and New Systemic Immune-Inflammation Indexes Are Associated with Overall Survival of Glioblastoma Patients Treated with Radio-Chemotherapy
title_full_unstemmed Old and New Systemic Immune-Inflammation Indexes Are Associated with Overall Survival of Glioblastoma Patients Treated with Radio-Chemotherapy
title_short Old and New Systemic Immune-Inflammation Indexes Are Associated with Overall Survival of Glioblastoma Patients Treated with Radio-Chemotherapy
title_sort old and new systemic immune-inflammation indexes are associated with overall survival of glioblastoma patients treated with radio-chemotherapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223226/
https://www.ncbi.nlm.nih.gov/pubmed/35741816
http://dx.doi.org/10.3390/genes13061054
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