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Cellular Senescence in Normal Mammary Gland and Breast Cancer. Implications for Cancer Therapy
Cellular senescence (CS) is a major homeostatic biological process, which plays a key role in normal tissue development and provides protection from stressful cell insults. The role of CS in mammary-gland development and breast cancer is not well understood. While there is a lack of experimental dat...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223240/ https://www.ncbi.nlm.nih.gov/pubmed/35741756 http://dx.doi.org/10.3390/genes13060994 |
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author | Sirinian, Chaido Peroukidis, Stavros Kriegsmann, Katharina Chaniotis, Dimitrios Koutras, Angelos Kriegsmann, Mark Papanastasiou, Anastasios D. |
author_facet | Sirinian, Chaido Peroukidis, Stavros Kriegsmann, Katharina Chaniotis, Dimitrios Koutras, Angelos Kriegsmann, Mark Papanastasiou, Anastasios D. |
author_sort | Sirinian, Chaido |
collection | PubMed |
description | Cellular senescence (CS) is a major homeostatic biological process, which plays a key role in normal tissue development and provides protection from stressful cell insults. The role of CS in mammary-gland development and breast cancer is not well understood. While there is a lack of experimental data on the role of CS in the development of the pre-pubertal mammary gland, there is evidence for a biphasic senescence response in adult normal-mammary-epithelial cells, where the bypass of the first senescence barrier (M0) seems to be a key step in the development of premalignant lesions, with genetic abnormalities that resemble in situ breast carcinoma. Further, there is accumulating evidence for the role of cellular senescence in breast-cancer response, regarding treatment and patient outcome. Here, we review the current literature on cellular senescence, in epithelial-mammary cells, breast-cancer cells, and breast-tumor-microenvironment-resident cells. Furthermore, we discuss its putative role in breast-cancer response, regarding treatment and disease progression. In addition, we provide preliminary evidence of CS in breast-cancer-microenvironment cells, such as tumor-associated fibroblasts and tumor-infiltrating lymphocytes, by employing the novel GL13 lipofuscin stain, as a marker of cellular senescence. |
format | Online Article Text |
id | pubmed-9223240 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92232402022-06-24 Cellular Senescence in Normal Mammary Gland and Breast Cancer. Implications for Cancer Therapy Sirinian, Chaido Peroukidis, Stavros Kriegsmann, Katharina Chaniotis, Dimitrios Koutras, Angelos Kriegsmann, Mark Papanastasiou, Anastasios D. Genes (Basel) Review Cellular senescence (CS) is a major homeostatic biological process, which plays a key role in normal tissue development and provides protection from stressful cell insults. The role of CS in mammary-gland development and breast cancer is not well understood. While there is a lack of experimental data on the role of CS in the development of the pre-pubertal mammary gland, there is evidence for a biphasic senescence response in adult normal-mammary-epithelial cells, where the bypass of the first senescence barrier (M0) seems to be a key step in the development of premalignant lesions, with genetic abnormalities that resemble in situ breast carcinoma. Further, there is accumulating evidence for the role of cellular senescence in breast-cancer response, regarding treatment and patient outcome. Here, we review the current literature on cellular senescence, in epithelial-mammary cells, breast-cancer cells, and breast-tumor-microenvironment-resident cells. Furthermore, we discuss its putative role in breast-cancer response, regarding treatment and disease progression. In addition, we provide preliminary evidence of CS in breast-cancer-microenvironment cells, such as tumor-associated fibroblasts and tumor-infiltrating lymphocytes, by employing the novel GL13 lipofuscin stain, as a marker of cellular senescence. MDPI 2022-06-01 /pmc/articles/PMC9223240/ /pubmed/35741756 http://dx.doi.org/10.3390/genes13060994 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sirinian, Chaido Peroukidis, Stavros Kriegsmann, Katharina Chaniotis, Dimitrios Koutras, Angelos Kriegsmann, Mark Papanastasiou, Anastasios D. Cellular Senescence in Normal Mammary Gland and Breast Cancer. Implications for Cancer Therapy |
title | Cellular Senescence in Normal Mammary Gland and Breast Cancer. Implications for Cancer Therapy |
title_full | Cellular Senescence in Normal Mammary Gland and Breast Cancer. Implications for Cancer Therapy |
title_fullStr | Cellular Senescence in Normal Mammary Gland and Breast Cancer. Implications for Cancer Therapy |
title_full_unstemmed | Cellular Senescence in Normal Mammary Gland and Breast Cancer. Implications for Cancer Therapy |
title_short | Cellular Senescence in Normal Mammary Gland and Breast Cancer. Implications for Cancer Therapy |
title_sort | cellular senescence in normal mammary gland and breast cancer. implications for cancer therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223240/ https://www.ncbi.nlm.nih.gov/pubmed/35741756 http://dx.doi.org/10.3390/genes13060994 |
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