Serine hydroxymethyltransferase as a potential target of antibacterial agents acting synergistically with one-carbon metabolism-related inhibitors

Serine hydroxymethyltransferase (SHMT) produces 5,10-methylenetetrahydrofolate (CH(2)-THF) from tetrahydrofolate with serine to glycine conversion. SHMT is a potential drug target in parasites, viruses and cancer. (+)-SHIN-1 was developed as a human SHMT inhibitor for cancer therapy. However, the po...

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Detalles Bibliográficos
Autores principales: Makino, Yuko, Oe, Chihiro, Iwama, Kazuya, Suzuki, Satoshi, Nishiyama, Akie, Hasegawa, Kazuya, Okuda, Haruka, Hirata, Kazushige, Ueno, Mariko, Kawaji, Kumi, Sasano, Mina, Usui, Emiko, Hosaka, Toshiaki, Yabuki, Yukako, Shirouzu, Mikako, Katsumi, Makoto, Murayama, Kazutaka, Hayashi, Hironori, Kodama, Eiichi N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223267/
https://www.ncbi.nlm.nih.gov/pubmed/35739195
http://dx.doi.org/10.1038/s42003-022-03555-x

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