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Using an antimalarial in mosquitoes overcomes Anopheles and Plasmodium resistance to malaria control strategies

The spread of insecticide resistance in Anopheles mosquitoes and drug resistance in Plasmodium parasites is contributing to a global resurgence of malaria, making the generation of control tools that can overcome these roadblocks an urgent public health priority. We recently showed that the transmis...

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Autores principales: Paton, Douglas G., Probst, Alexandra S., Ma, Erica, Adams, Kelsey L., Shaw, W. Robert, Singh, Naresh, Bopp, Selina, Volkman, Sarah K., Hien, Domombele F. S., Paré, Prislaure S. L., Yerbanga, Rakiswendé S., Diabaté, Abdoullaye, Dabiré, Roch K., Lefèvre, Thierry, Wirth, Dyann F., Catteruccia, Flaminia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223321/
https://www.ncbi.nlm.nih.gov/pubmed/35687594
http://dx.doi.org/10.1371/journal.ppat.1010609
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author Paton, Douglas G.
Probst, Alexandra S.
Ma, Erica
Adams, Kelsey L.
Shaw, W. Robert
Singh, Naresh
Bopp, Selina
Volkman, Sarah K.
Hien, Domombele F. S.
Paré, Prislaure S. L.
Yerbanga, Rakiswendé S.
Diabaté, Abdoullaye
Dabiré, Roch K.
Lefèvre, Thierry
Wirth, Dyann F.
Catteruccia, Flaminia
author_facet Paton, Douglas G.
Probst, Alexandra S.
Ma, Erica
Adams, Kelsey L.
Shaw, W. Robert
Singh, Naresh
Bopp, Selina
Volkman, Sarah K.
Hien, Domombele F. S.
Paré, Prislaure S. L.
Yerbanga, Rakiswendé S.
Diabaté, Abdoullaye
Dabiré, Roch K.
Lefèvre, Thierry
Wirth, Dyann F.
Catteruccia, Flaminia
author_sort Paton, Douglas G.
collection PubMed
description The spread of insecticide resistance in Anopheles mosquitoes and drug resistance in Plasmodium parasites is contributing to a global resurgence of malaria, making the generation of control tools that can overcome these roadblocks an urgent public health priority. We recently showed that the transmission of Plasmodium falciparum parasites can be efficiently blocked when exposing Anopheles gambiae females to antimalarials deposited on a treated surface, with no negative consequences on major components of mosquito fitness. Here, we demonstrate this approach can overcome the hurdles of insecticide resistance in mosquitoes and drug resistant in parasites. We show that the transmission-blocking efficacy of mosquito-targeted antimalarials is maintained when field-derived, insecticide resistant Anopheles are exposed to the potent cytochrome b inhibitor atovaquone, demonstrating that this drug escapes insecticide resistance mechanisms that could potentially interfere with its function. Moreover, this approach prevents transmission of field-derived, artemisinin resistant P. falciparum parasites (Kelch13 C580Y mutant), proving that this strategy could be used to prevent the spread of parasite mutations that induce resistance to front-line antimalarials. Atovaquone is also highly effective at limiting parasite development when ingested by mosquitoes in sugar solutions, including in ongoing infections. These data support the use of mosquito-targeted antimalarials as a promising tool to complement and extend the efficacy of current malaria control interventions.
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spelling pubmed-92233212022-06-24 Using an antimalarial in mosquitoes overcomes Anopheles and Plasmodium resistance to malaria control strategies Paton, Douglas G. Probst, Alexandra S. Ma, Erica Adams, Kelsey L. Shaw, W. Robert Singh, Naresh Bopp, Selina Volkman, Sarah K. Hien, Domombele F. S. Paré, Prislaure S. L. Yerbanga, Rakiswendé S. Diabaté, Abdoullaye Dabiré, Roch K. Lefèvre, Thierry Wirth, Dyann F. Catteruccia, Flaminia PLoS Pathog Research Article The spread of insecticide resistance in Anopheles mosquitoes and drug resistance in Plasmodium parasites is contributing to a global resurgence of malaria, making the generation of control tools that can overcome these roadblocks an urgent public health priority. We recently showed that the transmission of Plasmodium falciparum parasites can be efficiently blocked when exposing Anopheles gambiae females to antimalarials deposited on a treated surface, with no negative consequences on major components of mosquito fitness. Here, we demonstrate this approach can overcome the hurdles of insecticide resistance in mosquitoes and drug resistant in parasites. We show that the transmission-blocking efficacy of mosquito-targeted antimalarials is maintained when field-derived, insecticide resistant Anopheles are exposed to the potent cytochrome b inhibitor atovaquone, demonstrating that this drug escapes insecticide resistance mechanisms that could potentially interfere with its function. Moreover, this approach prevents transmission of field-derived, artemisinin resistant P. falciparum parasites (Kelch13 C580Y mutant), proving that this strategy could be used to prevent the spread of parasite mutations that induce resistance to front-line antimalarials. Atovaquone is also highly effective at limiting parasite development when ingested by mosquitoes in sugar solutions, including in ongoing infections. These data support the use of mosquito-targeted antimalarials as a promising tool to complement and extend the efficacy of current malaria control interventions. Public Library of Science 2022-06-10 /pmc/articles/PMC9223321/ /pubmed/35687594 http://dx.doi.org/10.1371/journal.ppat.1010609 Text en © 2022 Paton et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Paton, Douglas G.
Probst, Alexandra S.
Ma, Erica
Adams, Kelsey L.
Shaw, W. Robert
Singh, Naresh
Bopp, Selina
Volkman, Sarah K.
Hien, Domombele F. S.
Paré, Prislaure S. L.
Yerbanga, Rakiswendé S.
Diabaté, Abdoullaye
Dabiré, Roch K.
Lefèvre, Thierry
Wirth, Dyann F.
Catteruccia, Flaminia
Using an antimalarial in mosquitoes overcomes Anopheles and Plasmodium resistance to malaria control strategies
title Using an antimalarial in mosquitoes overcomes Anopheles and Plasmodium resistance to malaria control strategies
title_full Using an antimalarial in mosquitoes overcomes Anopheles and Plasmodium resistance to malaria control strategies
title_fullStr Using an antimalarial in mosquitoes overcomes Anopheles and Plasmodium resistance to malaria control strategies
title_full_unstemmed Using an antimalarial in mosquitoes overcomes Anopheles and Plasmodium resistance to malaria control strategies
title_short Using an antimalarial in mosquitoes overcomes Anopheles and Plasmodium resistance to malaria control strategies
title_sort using an antimalarial in mosquitoes overcomes anopheles and plasmodium resistance to malaria control strategies
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223321/
https://www.ncbi.nlm.nih.gov/pubmed/35687594
http://dx.doi.org/10.1371/journal.ppat.1010609
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