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Using an antimalarial in mosquitoes overcomes Anopheles and Plasmodium resistance to malaria control strategies
The spread of insecticide resistance in Anopheles mosquitoes and drug resistance in Plasmodium parasites is contributing to a global resurgence of malaria, making the generation of control tools that can overcome these roadblocks an urgent public health priority. We recently showed that the transmis...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223321/ https://www.ncbi.nlm.nih.gov/pubmed/35687594 http://dx.doi.org/10.1371/journal.ppat.1010609 |
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author | Paton, Douglas G. Probst, Alexandra S. Ma, Erica Adams, Kelsey L. Shaw, W. Robert Singh, Naresh Bopp, Selina Volkman, Sarah K. Hien, Domombele F. S. Paré, Prislaure S. L. Yerbanga, Rakiswendé S. Diabaté, Abdoullaye Dabiré, Roch K. Lefèvre, Thierry Wirth, Dyann F. Catteruccia, Flaminia |
author_facet | Paton, Douglas G. Probst, Alexandra S. Ma, Erica Adams, Kelsey L. Shaw, W. Robert Singh, Naresh Bopp, Selina Volkman, Sarah K. Hien, Domombele F. S. Paré, Prislaure S. L. Yerbanga, Rakiswendé S. Diabaté, Abdoullaye Dabiré, Roch K. Lefèvre, Thierry Wirth, Dyann F. Catteruccia, Flaminia |
author_sort | Paton, Douglas G. |
collection | PubMed |
description | The spread of insecticide resistance in Anopheles mosquitoes and drug resistance in Plasmodium parasites is contributing to a global resurgence of malaria, making the generation of control tools that can overcome these roadblocks an urgent public health priority. We recently showed that the transmission of Plasmodium falciparum parasites can be efficiently blocked when exposing Anopheles gambiae females to antimalarials deposited on a treated surface, with no negative consequences on major components of mosquito fitness. Here, we demonstrate this approach can overcome the hurdles of insecticide resistance in mosquitoes and drug resistant in parasites. We show that the transmission-blocking efficacy of mosquito-targeted antimalarials is maintained when field-derived, insecticide resistant Anopheles are exposed to the potent cytochrome b inhibitor atovaquone, demonstrating that this drug escapes insecticide resistance mechanisms that could potentially interfere with its function. Moreover, this approach prevents transmission of field-derived, artemisinin resistant P. falciparum parasites (Kelch13 C580Y mutant), proving that this strategy could be used to prevent the spread of parasite mutations that induce resistance to front-line antimalarials. Atovaquone is also highly effective at limiting parasite development when ingested by mosquitoes in sugar solutions, including in ongoing infections. These data support the use of mosquito-targeted antimalarials as a promising tool to complement and extend the efficacy of current malaria control interventions. |
format | Online Article Text |
id | pubmed-9223321 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-92233212022-06-24 Using an antimalarial in mosquitoes overcomes Anopheles and Plasmodium resistance to malaria control strategies Paton, Douglas G. Probst, Alexandra S. Ma, Erica Adams, Kelsey L. Shaw, W. Robert Singh, Naresh Bopp, Selina Volkman, Sarah K. Hien, Domombele F. S. Paré, Prislaure S. L. Yerbanga, Rakiswendé S. Diabaté, Abdoullaye Dabiré, Roch K. Lefèvre, Thierry Wirth, Dyann F. Catteruccia, Flaminia PLoS Pathog Research Article The spread of insecticide resistance in Anopheles mosquitoes and drug resistance in Plasmodium parasites is contributing to a global resurgence of malaria, making the generation of control tools that can overcome these roadblocks an urgent public health priority. We recently showed that the transmission of Plasmodium falciparum parasites can be efficiently blocked when exposing Anopheles gambiae females to antimalarials deposited on a treated surface, with no negative consequences on major components of mosquito fitness. Here, we demonstrate this approach can overcome the hurdles of insecticide resistance in mosquitoes and drug resistant in parasites. We show that the transmission-blocking efficacy of mosquito-targeted antimalarials is maintained when field-derived, insecticide resistant Anopheles are exposed to the potent cytochrome b inhibitor atovaquone, demonstrating that this drug escapes insecticide resistance mechanisms that could potentially interfere with its function. Moreover, this approach prevents transmission of field-derived, artemisinin resistant P. falciparum parasites (Kelch13 C580Y mutant), proving that this strategy could be used to prevent the spread of parasite mutations that induce resistance to front-line antimalarials. Atovaquone is also highly effective at limiting parasite development when ingested by mosquitoes in sugar solutions, including in ongoing infections. These data support the use of mosquito-targeted antimalarials as a promising tool to complement and extend the efficacy of current malaria control interventions. Public Library of Science 2022-06-10 /pmc/articles/PMC9223321/ /pubmed/35687594 http://dx.doi.org/10.1371/journal.ppat.1010609 Text en © 2022 Paton et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Paton, Douglas G. Probst, Alexandra S. Ma, Erica Adams, Kelsey L. Shaw, W. Robert Singh, Naresh Bopp, Selina Volkman, Sarah K. Hien, Domombele F. S. Paré, Prislaure S. L. Yerbanga, Rakiswendé S. Diabaté, Abdoullaye Dabiré, Roch K. Lefèvre, Thierry Wirth, Dyann F. Catteruccia, Flaminia Using an antimalarial in mosquitoes overcomes Anopheles and Plasmodium resistance to malaria control strategies |
title | Using an antimalarial in mosquitoes overcomes Anopheles and Plasmodium resistance to malaria control strategies |
title_full | Using an antimalarial in mosquitoes overcomes Anopheles and Plasmodium resistance to malaria control strategies |
title_fullStr | Using an antimalarial in mosquitoes overcomes Anopheles and Plasmodium resistance to malaria control strategies |
title_full_unstemmed | Using an antimalarial in mosquitoes overcomes Anopheles and Plasmodium resistance to malaria control strategies |
title_short | Using an antimalarial in mosquitoes overcomes Anopheles and Plasmodium resistance to malaria control strategies |
title_sort | using an antimalarial in mosquitoes overcomes anopheles and plasmodium resistance to malaria control strategies |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223321/ https://www.ncbi.nlm.nih.gov/pubmed/35687594 http://dx.doi.org/10.1371/journal.ppat.1010609 |
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