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An Overview of the Importance of Transition-Metal Nanoparticles in Cancer Research

Several authorities have implied that nanotechnology has a significant future in the development of advanced cancer therapies. Nanotechnology makes it possible to simultaneously administer drug combinations and engage the immune system to fight cancer. Nanoparticles can locate metastases in differen...

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Autores principales: Szewczyk, Olga Klaudia, Roszczenko, Piotr, Czarnomysy, Robert, Bielawska, Anna, Bielawski, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223356/
https://www.ncbi.nlm.nih.gov/pubmed/35743130
http://dx.doi.org/10.3390/ijms23126688
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author Szewczyk, Olga Klaudia
Roszczenko, Piotr
Czarnomysy, Robert
Bielawska, Anna
Bielawski, Krzysztof
author_facet Szewczyk, Olga Klaudia
Roszczenko, Piotr
Czarnomysy, Robert
Bielawska, Anna
Bielawski, Krzysztof
author_sort Szewczyk, Olga Klaudia
collection PubMed
description Several authorities have implied that nanotechnology has a significant future in the development of advanced cancer therapies. Nanotechnology makes it possible to simultaneously administer drug combinations and engage the immune system to fight cancer. Nanoparticles can locate metastases in different organs and deliver medications to them. Using them allows for the effective reduction of tumors with minimal toxicity to healthy tissue. Transition-metal nanoparticles, through Fenton-type or Haber–Weiss-type reactions, generate reactive oxygen species. Through oxidative stress, the particles induce cell death via different pathways. The main limitation of the particles is their toxicity. Certain factors can control toxicity, such as route of administration, size, aggregation state, surface functionalization, or oxidation state. In this review, we attempt to discuss the effects and toxicity of transition-metal nanoparticles.
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spelling pubmed-92233562022-06-24 An Overview of the Importance of Transition-Metal Nanoparticles in Cancer Research Szewczyk, Olga Klaudia Roszczenko, Piotr Czarnomysy, Robert Bielawska, Anna Bielawski, Krzysztof Int J Mol Sci Review Several authorities have implied that nanotechnology has a significant future in the development of advanced cancer therapies. Nanotechnology makes it possible to simultaneously administer drug combinations and engage the immune system to fight cancer. Nanoparticles can locate metastases in different organs and deliver medications to them. Using them allows for the effective reduction of tumors with minimal toxicity to healthy tissue. Transition-metal nanoparticles, through Fenton-type or Haber–Weiss-type reactions, generate reactive oxygen species. Through oxidative stress, the particles induce cell death via different pathways. The main limitation of the particles is their toxicity. Certain factors can control toxicity, such as route of administration, size, aggregation state, surface functionalization, or oxidation state. In this review, we attempt to discuss the effects and toxicity of transition-metal nanoparticles. MDPI 2022-06-15 /pmc/articles/PMC9223356/ /pubmed/35743130 http://dx.doi.org/10.3390/ijms23126688 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Szewczyk, Olga Klaudia
Roszczenko, Piotr
Czarnomysy, Robert
Bielawska, Anna
Bielawski, Krzysztof
An Overview of the Importance of Transition-Metal Nanoparticles in Cancer Research
title An Overview of the Importance of Transition-Metal Nanoparticles in Cancer Research
title_full An Overview of the Importance of Transition-Metal Nanoparticles in Cancer Research
title_fullStr An Overview of the Importance of Transition-Metal Nanoparticles in Cancer Research
title_full_unstemmed An Overview of the Importance of Transition-Metal Nanoparticles in Cancer Research
title_short An Overview of the Importance of Transition-Metal Nanoparticles in Cancer Research
title_sort overview of the importance of transition-metal nanoparticles in cancer research
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223356/
https://www.ncbi.nlm.nih.gov/pubmed/35743130
http://dx.doi.org/10.3390/ijms23126688
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