CRISPR/Cas9-Mediated Constitutive Loss of VCP (Valosin-Containing Protein) Impairs Proteostasis and Leads to Defective Striated Muscle Structure and Function In Vivo

Valosin-containing protein (VCP) acts as a key regulator of cellular protein homeostasis by coordinating protein turnover and quality control. Mutations in VCP lead to (cardio-)myopathy and neurodegenerative diseases such as inclusion body myopathy with Paget’s disease of the bone and frontotemporal...

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Detalles Bibliográficos
Autores principales: Voisard, Philipp, Diofano, Federica, Glazier, Amelia A., Rottbauer, Wolfgang, Just, Steffen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223409/
https://www.ncbi.nlm.nih.gov/pubmed/35743185
http://dx.doi.org/10.3390/ijms23126722

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223409/
https://www.ncbi.nlm.nih.gov/pubmed/35743185
http://dx.doi.org/10.3390/ijms23126722

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