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Association of Hyperuricemia with Impaired Left Ventricular Systolic Function in Patients with Atrial Fibrillation and Preserved Kidney Function: Analysis of the POL-AF Registry Cohort
Hyperuricemia is associated with the risk of developing atrial fibrillation (AF) and heart failure. However, coexisting chronic kidney disease and certain cardiovascular drugs make it difficult to determine whether hyperuricemia is a risk factor or merely a marker of pathology. We retrieved data fro...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223418/ https://www.ncbi.nlm.nih.gov/pubmed/35742536 http://dx.doi.org/10.3390/ijerph19127288 |
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author | Wełnicki, Marcin Gorczyca-Głowacka, Iwona Lubas, Arkadiusz Wójcik, Wiktor Jelonek, Olga Maciorowska, Małgorzata Uziębło-Życzkowska, Beata Wójcik, Maciej Błaszczyk, Robert Rajtar-Salwa, Renata Tokarek, Tomasz Bil, Jacek Wojewódzki, Michał Szpotowicz, Anna Krzciuk, Małgorzata Gawałko, Monika Kapłon-Cieślicka, Agnieszka Tomaszuk-Kazberuk, Anna Szyszkowska, Anna Bednarski, Janusz Bakuła-Ostalska, Elwira Wożakowska-Kapłon, Beata Mamcarz, Artur |
author_facet | Wełnicki, Marcin Gorczyca-Głowacka, Iwona Lubas, Arkadiusz Wójcik, Wiktor Jelonek, Olga Maciorowska, Małgorzata Uziębło-Życzkowska, Beata Wójcik, Maciej Błaszczyk, Robert Rajtar-Salwa, Renata Tokarek, Tomasz Bil, Jacek Wojewódzki, Michał Szpotowicz, Anna Krzciuk, Małgorzata Gawałko, Monika Kapłon-Cieślicka, Agnieszka Tomaszuk-Kazberuk, Anna Szyszkowska, Anna Bednarski, Janusz Bakuła-Ostalska, Elwira Wożakowska-Kapłon, Beata Mamcarz, Artur |
author_sort | Wełnicki, Marcin |
collection | PubMed |
description | Hyperuricemia is associated with the risk of developing atrial fibrillation (AF) and heart failure. However, coexisting chronic kidney disease and certain cardiovascular drugs make it difficult to determine whether hyperuricemia is a risk factor or merely a marker of pathology. We retrieved data from the Polish Atrial Fibrillation (POL-AF) registry, which included consecutive patients hospitalized with AF from January to December, 2019. We included 829 patients (mean age: 72.7 ± 11.1 years) with data on serum uric acid (UA, mean: 6.56 ± 1.78 mg/dL) and estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m(2). We found that UA and ejection fraction (EF) were significantly correlated (r = −0.15, p < 0.05), but not EF and eGFR or eGFR and UA. A multiple regression analysis adjusted for age, body mass index, eGFR, and UA, showed that UA was significantly associated with a reduced EF (R(2): 0.021; p < 0.001). The UA cut-off indicative of an EF < 40% was 6.69 mg/dL (AUC, area under the curve: 0.607; 95% CI: 0.554–0.660; p = 0.001). Among drugs known to effect UA concentrations, we found that only diuretics were used more frequently in patients with high UA (above the median) than in patients with low UA (77.5% vs. 67%, p < 0.001). Among patients that used diuretics, UA remained significantly correlated with EF. Thus, we showed that reduced EF was associated with UA in patients with AF and normal renal function, independent of eGFR and diuretic use. |
format | Online Article Text |
id | pubmed-9223418 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92234182022-06-24 Association of Hyperuricemia with Impaired Left Ventricular Systolic Function in Patients with Atrial Fibrillation and Preserved Kidney Function: Analysis of the POL-AF Registry Cohort Wełnicki, Marcin Gorczyca-Głowacka, Iwona Lubas, Arkadiusz Wójcik, Wiktor Jelonek, Olga Maciorowska, Małgorzata Uziębło-Życzkowska, Beata Wójcik, Maciej Błaszczyk, Robert Rajtar-Salwa, Renata Tokarek, Tomasz Bil, Jacek Wojewódzki, Michał Szpotowicz, Anna Krzciuk, Małgorzata Gawałko, Monika Kapłon-Cieślicka, Agnieszka Tomaszuk-Kazberuk, Anna Szyszkowska, Anna Bednarski, Janusz Bakuła-Ostalska, Elwira Wożakowska-Kapłon, Beata Mamcarz, Artur Int J Environ Res Public Health Article Hyperuricemia is associated with the risk of developing atrial fibrillation (AF) and heart failure. However, coexisting chronic kidney disease and certain cardiovascular drugs make it difficult to determine whether hyperuricemia is a risk factor or merely a marker of pathology. We retrieved data from the Polish Atrial Fibrillation (POL-AF) registry, which included consecutive patients hospitalized with AF from January to December, 2019. We included 829 patients (mean age: 72.7 ± 11.1 years) with data on serum uric acid (UA, mean: 6.56 ± 1.78 mg/dL) and estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m(2). We found that UA and ejection fraction (EF) were significantly correlated (r = −0.15, p < 0.05), but not EF and eGFR or eGFR and UA. A multiple regression analysis adjusted for age, body mass index, eGFR, and UA, showed that UA was significantly associated with a reduced EF (R(2): 0.021; p < 0.001). The UA cut-off indicative of an EF < 40% was 6.69 mg/dL (AUC, area under the curve: 0.607; 95% CI: 0.554–0.660; p = 0.001). Among drugs known to effect UA concentrations, we found that only diuretics were used more frequently in patients with high UA (above the median) than in patients with low UA (77.5% vs. 67%, p < 0.001). Among patients that used diuretics, UA remained significantly correlated with EF. Thus, we showed that reduced EF was associated with UA in patients with AF and normal renal function, independent of eGFR and diuretic use. MDPI 2022-06-14 /pmc/articles/PMC9223418/ /pubmed/35742536 http://dx.doi.org/10.3390/ijerph19127288 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wełnicki, Marcin Gorczyca-Głowacka, Iwona Lubas, Arkadiusz Wójcik, Wiktor Jelonek, Olga Maciorowska, Małgorzata Uziębło-Życzkowska, Beata Wójcik, Maciej Błaszczyk, Robert Rajtar-Salwa, Renata Tokarek, Tomasz Bil, Jacek Wojewódzki, Michał Szpotowicz, Anna Krzciuk, Małgorzata Gawałko, Monika Kapłon-Cieślicka, Agnieszka Tomaszuk-Kazberuk, Anna Szyszkowska, Anna Bednarski, Janusz Bakuła-Ostalska, Elwira Wożakowska-Kapłon, Beata Mamcarz, Artur Association of Hyperuricemia with Impaired Left Ventricular Systolic Function in Patients with Atrial Fibrillation and Preserved Kidney Function: Analysis of the POL-AF Registry Cohort |
title | Association of Hyperuricemia with Impaired Left Ventricular Systolic Function in Patients with Atrial Fibrillation and Preserved Kidney Function: Analysis of the POL-AF Registry Cohort |
title_full | Association of Hyperuricemia with Impaired Left Ventricular Systolic Function in Patients with Atrial Fibrillation and Preserved Kidney Function: Analysis of the POL-AF Registry Cohort |
title_fullStr | Association of Hyperuricemia with Impaired Left Ventricular Systolic Function in Patients with Atrial Fibrillation and Preserved Kidney Function: Analysis of the POL-AF Registry Cohort |
title_full_unstemmed | Association of Hyperuricemia with Impaired Left Ventricular Systolic Function in Patients with Atrial Fibrillation and Preserved Kidney Function: Analysis of the POL-AF Registry Cohort |
title_short | Association of Hyperuricemia with Impaired Left Ventricular Systolic Function in Patients with Atrial Fibrillation and Preserved Kidney Function: Analysis of the POL-AF Registry Cohort |
title_sort | association of hyperuricemia with impaired left ventricular systolic function in patients with atrial fibrillation and preserved kidney function: analysis of the pol-af registry cohort |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223418/ https://www.ncbi.nlm.nih.gov/pubmed/35742536 http://dx.doi.org/10.3390/ijerph19127288 |
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