Cargando…
Application of Sensitivity Analysis to Discover Potential Molecular Drug Targets
Mathematical modeling of signaling pathways and regulatory networks has been supporting experimental research for some time now. Sensitivity analysis, aimed at finding model parameters whose changes yield significantly altered cellular responses, is an important part of modeling work. However, sensi...
Autores principales: | Kardynska, Malgorzata, Smieja, Jaroslaw, Paszek, Pawel, Puszynski, Krzysztof |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223434/ https://www.ncbi.nlm.nih.gov/pubmed/35743048 http://dx.doi.org/10.3390/ijms23126604 |
Ejemplares similares
-
Petri nets and ODEs as complementary methods for comprehensive analysis on an example of the ATM–p53–NF-[Formula: see text] B signaling pathways
por: Gutowska, Kaja, et al.
Publicado: (2022) -
Heat shock response regulates stimulus-specificity and sensitivity of the pro-inflammatory NF-κB signalling
por: Paszek, Anna, et al.
Publicado: (2020) -
Quantitative analysis reveals crosstalk mechanisms of heat shock-induced attenuation of NF-κB signaling at the single cell level
por: Kardyńska, Małgorzata, et al.
Publicado: (2018) -
Post-transcriptional regulatory feedback encodes JAK-STAT signal memory of interferon stimulation
por: Kalliara, Eirini, et al.
Publicado: (2022) -
Mathematical modeling of regulatory networks of intracellular processes – Aims and selected methods
por: Kardynska, Malgorzata, et al.
Publicado: (2023)