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Genetics and Epigenetics of Spontaneous Intracerebral Hemorrhage

Intracerebral hemorrhage (ICH) is a complex and heterogeneous disease, and there is no effective treatment. Spontaneous ICH represents the final manifestation of different types of cerebral small vessel disease, usually categorized as: lobar (mostly related to cerebral amyloid angiopathy) and nonlob...

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Autores principales: Giralt-Steinhauer, Eva, Jiménez-Balado, Joan, Fernández-Pérez, Isabel, Rey Álvarez, Lucía, Rodríguez-Campello, Ana, Ois, Ángel, Cuadrado-Godia, Elisa, Jiménez-Conde, Jordi, Roquer, Jaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223468/
https://www.ncbi.nlm.nih.gov/pubmed/35742924
http://dx.doi.org/10.3390/ijms23126479
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author Giralt-Steinhauer, Eva
Jiménez-Balado, Joan
Fernández-Pérez, Isabel
Rey Álvarez, Lucía
Rodríguez-Campello, Ana
Ois, Ángel
Cuadrado-Godia, Elisa
Jiménez-Conde, Jordi
Roquer, Jaume
author_facet Giralt-Steinhauer, Eva
Jiménez-Balado, Joan
Fernández-Pérez, Isabel
Rey Álvarez, Lucía
Rodríguez-Campello, Ana
Ois, Ángel
Cuadrado-Godia, Elisa
Jiménez-Conde, Jordi
Roquer, Jaume
author_sort Giralt-Steinhauer, Eva
collection PubMed
description Intracerebral hemorrhage (ICH) is a complex and heterogeneous disease, and there is no effective treatment. Spontaneous ICH represents the final manifestation of different types of cerebral small vessel disease, usually categorized as: lobar (mostly related to cerebral amyloid angiopathy) and nonlobar (hypertension-related vasculopathy) ICH. Accurate phenotyping aims to reflect these biological differences in the underlying mechanisms and has been demonstrated to be crucial to the success of genetic studies in this field. This review summarizes how current knowledge on genetics and epigenetics of this devastating stroke subtype are contributing to improve the understanding of ICH pathophysiology and their potential role in developing therapeutic strategies.
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spelling pubmed-92234682022-06-24 Genetics and Epigenetics of Spontaneous Intracerebral Hemorrhage Giralt-Steinhauer, Eva Jiménez-Balado, Joan Fernández-Pérez, Isabel Rey Álvarez, Lucía Rodríguez-Campello, Ana Ois, Ángel Cuadrado-Godia, Elisa Jiménez-Conde, Jordi Roquer, Jaume Int J Mol Sci Review Intracerebral hemorrhage (ICH) is a complex and heterogeneous disease, and there is no effective treatment. Spontaneous ICH represents the final manifestation of different types of cerebral small vessel disease, usually categorized as: lobar (mostly related to cerebral amyloid angiopathy) and nonlobar (hypertension-related vasculopathy) ICH. Accurate phenotyping aims to reflect these biological differences in the underlying mechanisms and has been demonstrated to be crucial to the success of genetic studies in this field. This review summarizes how current knowledge on genetics and epigenetics of this devastating stroke subtype are contributing to improve the understanding of ICH pathophysiology and their potential role in developing therapeutic strategies. MDPI 2022-06-09 /pmc/articles/PMC9223468/ /pubmed/35742924 http://dx.doi.org/10.3390/ijms23126479 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Giralt-Steinhauer, Eva
Jiménez-Balado, Joan
Fernández-Pérez, Isabel
Rey Álvarez, Lucía
Rodríguez-Campello, Ana
Ois, Ángel
Cuadrado-Godia, Elisa
Jiménez-Conde, Jordi
Roquer, Jaume
Genetics and Epigenetics of Spontaneous Intracerebral Hemorrhage
title Genetics and Epigenetics of Spontaneous Intracerebral Hemorrhage
title_full Genetics and Epigenetics of Spontaneous Intracerebral Hemorrhage
title_fullStr Genetics and Epigenetics of Spontaneous Intracerebral Hemorrhage
title_full_unstemmed Genetics and Epigenetics of Spontaneous Intracerebral Hemorrhage
title_short Genetics and Epigenetics of Spontaneous Intracerebral Hemorrhage
title_sort genetics and epigenetics of spontaneous intracerebral hemorrhage
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223468/
https://www.ncbi.nlm.nih.gov/pubmed/35742924
http://dx.doi.org/10.3390/ijms23126479
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