Monocyte–Macrophage Lineage Cell Fusion

Cell fusion (fusogenesis) occurs in natural and pathological conditions in prokaryotes and eukaryotes. Cells of monocyte–macrophage lineage are highly fusogenic. They create syncytial multinucleated giant cells (MGCs) such as osteoclasts (OCs), MGCs associated with the areas of infection/inflammatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Kloc, Malgorzata, Subuddhi, Arijita, Uosef, Ahmed, Kubiak, Jacek Z., Ghobrial, Rafik M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223484/
https://www.ncbi.nlm.nih.gov/pubmed/35742997
http://dx.doi.org/10.3390/ijms23126553
Descripción
Sumario:Cell fusion (fusogenesis) occurs in natural and pathological conditions in prokaryotes and eukaryotes. Cells of monocyte–macrophage lineage are highly fusogenic. They create syncytial multinucleated giant cells (MGCs) such as osteoclasts (OCs), MGCs associated with the areas of infection/inflammation, and foreign body-induced giant cells (FBGCs). The fusion of monocytes/macrophages with tumor cells may promote cancer metastasis. We describe types and examples of monocyte–macrophage lineage cell fusion and the role of actin-based structures in cell fusion.

Ejemplares similares