Monocyte–Macrophage Lineage Cell Fusion

Cell fusion (fusogenesis) occurs in natural and pathological conditions in prokaryotes and eukaryotes. Cells of monocyte–macrophage lineage are highly fusogenic. They create syncytial multinucleated giant cells (MGCs) such as osteoclasts (OCs), MGCs associated with the areas of infection/inflammatio...

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Detalles Bibliográficos
Autores principales: Kloc, Malgorzata, Subuddhi, Arijita, Uosef, Ahmed, Kubiak, Jacek Z., Ghobrial, Rafik M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223484/
https://www.ncbi.nlm.nih.gov/pubmed/35742997
http://dx.doi.org/10.3390/ijms23126553
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author Kloc, Malgorzata
Subuddhi, Arijita
Uosef, Ahmed
Kubiak, Jacek Z.
Ghobrial, Rafik M.
author_facet Kloc, Malgorzata
Subuddhi, Arijita
Uosef, Ahmed
Kubiak, Jacek Z.
Ghobrial, Rafik M.
author_sort Kloc, Malgorzata
collection PubMed
description Cell fusion (fusogenesis) occurs in natural and pathological conditions in prokaryotes and eukaryotes. Cells of monocyte–macrophage lineage are highly fusogenic. They create syncytial multinucleated giant cells (MGCs) such as osteoclasts (OCs), MGCs associated with the areas of infection/inflammation, and foreign body-induced giant cells (FBGCs). The fusion of monocytes/macrophages with tumor cells may promote cancer metastasis. We describe types and examples of monocyte–macrophage lineage cell fusion and the role of actin-based structures in cell fusion.
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spelling pubmed-92234842022-06-24 Monocyte–Macrophage Lineage Cell Fusion Kloc, Malgorzata Subuddhi, Arijita Uosef, Ahmed Kubiak, Jacek Z. Ghobrial, Rafik M. Int J Mol Sci Review Cell fusion (fusogenesis) occurs in natural and pathological conditions in prokaryotes and eukaryotes. Cells of monocyte–macrophage lineage are highly fusogenic. They create syncytial multinucleated giant cells (MGCs) such as osteoclasts (OCs), MGCs associated with the areas of infection/inflammation, and foreign body-induced giant cells (FBGCs). The fusion of monocytes/macrophages with tumor cells may promote cancer metastasis. We describe types and examples of monocyte–macrophage lineage cell fusion and the role of actin-based structures in cell fusion. MDPI 2022-06-12 /pmc/articles/PMC9223484/ /pubmed/35742997 http://dx.doi.org/10.3390/ijms23126553 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kloc, Malgorzata
Subuddhi, Arijita
Uosef, Ahmed
Kubiak, Jacek Z.
Ghobrial, Rafik M.
Monocyte–Macrophage Lineage Cell Fusion
title Monocyte–Macrophage Lineage Cell Fusion
title_full Monocyte–Macrophage Lineage Cell Fusion
title_fullStr Monocyte–Macrophage Lineage Cell Fusion
title_full_unstemmed Monocyte–Macrophage Lineage Cell Fusion
title_short Monocyte–Macrophage Lineage Cell Fusion
title_sort monocyte–macrophage lineage cell fusion
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223484/
https://www.ncbi.nlm.nih.gov/pubmed/35742997
http://dx.doi.org/10.3390/ijms23126553
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AT uosefahmed monocytemacrophagelineagecellfusion
AT kubiakjacekz monocytemacrophagelineagecellfusion
AT ghobrialrafikm monocytemacrophagelineagecellfusion

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