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Is There an Association between the Use of Epidural Analgesia during Labor and the Development of Autism Spectrum Disorder in the Offspring?—A Review of the Literature

Autism spectrum disorders (ASDs) are multifactorial and complex neurodevelopmental conditions usually diagnosed in the early childhood. The etiology of ASDs is commonly described as a genetic predisposition combined with an environmental impact. As a result of broadening of the diagnostic criteria t...

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Autores principales: Król, Joanna Weronika, Stanirowski, Paweł Jan, Mazanowska, Natalia, Majewska, Agata, Wielgoś, Mirosław, Bomba-Opoń, Dorota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223492/
https://www.ncbi.nlm.nih.gov/pubmed/35742451
http://dx.doi.org/10.3390/ijerph19127202
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author Król, Joanna Weronika
Stanirowski, Paweł Jan
Mazanowska, Natalia
Majewska, Agata
Wielgoś, Mirosław
Bomba-Opoń, Dorota
author_facet Król, Joanna Weronika
Stanirowski, Paweł Jan
Mazanowska, Natalia
Majewska, Agata
Wielgoś, Mirosław
Bomba-Opoń, Dorota
author_sort Król, Joanna Weronika
collection PubMed
description Autism spectrum disorders (ASDs) are multifactorial and complex neurodevelopmental conditions usually diagnosed in the early childhood. The etiology of ASDs is commonly described as a genetic predisposition combined with an environmental impact. As a result of broadening of the diagnostic criteria the prevalence of ASDs has been increasing worldwide and the search for the modifiable factors is still on-going. Epidural analgesia (ELA) provides effective pain relief during labor and is currently the most preferred method of anesthesia during the delivery. The safety of the procedure is well-discussed and documented; nonetheless, in 2020 a single population-based study indicated an association between the use of ELA during labor and newborn risk of ASD development, which led to widespread concern. To explore the possible association between the ELA and ASD occurrence in the offspring several studies in different countries have been conducted to date. In this review we aimed to summarize the current state of knowledge concerning the association between the use of epidural analgesia during labor and risk of ASD. In conclusion, the literature review indicates that there is no significant association.
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spelling pubmed-92234922022-06-24 Is There an Association between the Use of Epidural Analgesia during Labor and the Development of Autism Spectrum Disorder in the Offspring?—A Review of the Literature Król, Joanna Weronika Stanirowski, Paweł Jan Mazanowska, Natalia Majewska, Agata Wielgoś, Mirosław Bomba-Opoń, Dorota Int J Environ Res Public Health Review Autism spectrum disorders (ASDs) are multifactorial and complex neurodevelopmental conditions usually diagnosed in the early childhood. The etiology of ASDs is commonly described as a genetic predisposition combined with an environmental impact. As a result of broadening of the diagnostic criteria the prevalence of ASDs has been increasing worldwide and the search for the modifiable factors is still on-going. Epidural analgesia (ELA) provides effective pain relief during labor and is currently the most preferred method of anesthesia during the delivery. The safety of the procedure is well-discussed and documented; nonetheless, in 2020 a single population-based study indicated an association between the use of ELA during labor and newborn risk of ASD development, which led to widespread concern. To explore the possible association between the ELA and ASD occurrence in the offspring several studies in different countries have been conducted to date. In this review we aimed to summarize the current state of knowledge concerning the association between the use of epidural analgesia during labor and risk of ASD. In conclusion, the literature review indicates that there is no significant association. MDPI 2022-06-12 /pmc/articles/PMC9223492/ /pubmed/35742451 http://dx.doi.org/10.3390/ijerph19127202 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Król, Joanna Weronika
Stanirowski, Paweł Jan
Mazanowska, Natalia
Majewska, Agata
Wielgoś, Mirosław
Bomba-Opoń, Dorota
Is There an Association between the Use of Epidural Analgesia during Labor and the Development of Autism Spectrum Disorder in the Offspring?—A Review of the Literature
title Is There an Association between the Use of Epidural Analgesia during Labor and the Development of Autism Spectrum Disorder in the Offspring?—A Review of the Literature
title_full Is There an Association between the Use of Epidural Analgesia during Labor and the Development of Autism Spectrum Disorder in the Offspring?—A Review of the Literature
title_fullStr Is There an Association between the Use of Epidural Analgesia during Labor and the Development of Autism Spectrum Disorder in the Offspring?—A Review of the Literature
title_full_unstemmed Is There an Association between the Use of Epidural Analgesia during Labor and the Development of Autism Spectrum Disorder in the Offspring?—A Review of the Literature
title_short Is There an Association between the Use of Epidural Analgesia during Labor and the Development of Autism Spectrum Disorder in the Offspring?—A Review of the Literature
title_sort is there an association between the use of epidural analgesia during labor and the development of autism spectrum disorder in the offspring?—a review of the literature
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223492/
https://www.ncbi.nlm.nih.gov/pubmed/35742451
http://dx.doi.org/10.3390/ijerph19127202
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