Cargando…

Brexpiprazole Reduces 5-HT7 Receptor Function on Astroglial Transmission Systems

Several atypical antipsychotics exert mood-stabilising effects via the modulation of various monoamine receptors and intracellular signallings. Recent pharmacodynamic studies suggested that tripartite synaptic transmission can contribute to the pathophysiology of schizophrenia and mood disorders, th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fukuyama, Kouji, Motomura, Eishi, Okada, Motohiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223571/ https://www.ncbi.nlm.nih.gov/pubmed/35743014 http://dx.doi.org/10.3390/ijms23126571

Ejemplares similares

Effects of Atypical Antipsychotics, Clozapine, Quetiapine and Brexpiprazole on Astroglial Transmission Associated with Connexin43
por: Fukuyama, Kouji, et al.
Publicado: (2021)

Opposing effects of clozapine and brexpiprazole on β-aminoisobutyric acid: Pathophysiology of antipsychotics-induced weight gain
por: Fukuyama, Kouji, et al.
Publicado: (2023)

Dose-Dependent Biphasic Action of Quetiapine on AMPK Signalling via 5-HT7 Receptor: Exploring Pathophysiology of Clinical and Adverse Effects of Quetiapine
por: Okada, Motohiro, et al.
Publicado: (2022)

Therapeutic Potential and Limitation of Serotonin Type 7 Receptor Modulation
por: Fukuyama, Kouji, et al.
Publicado: (2023)

Vortioxetine Subchronically Activates Serotonergic Transmission via Desensitization of Serotonin 5-HT(1A) Receptor with 5-HT(3) Receptor Inhibition in Rats
por: Okada, Motohiro, et al.
Publicado: (2019)

Lurasidone Sub-Chronically Activates Serotonergic Transmission via Desensitization of 5-HT1A and 5-HT7 Receptors in Dorsal Raphe Nucleus
por: Okada, Motohiro, et al.
Publicado: (2019)

Effects of Subchronic Administrations of Vortioxetine, Lurasidone, and Escitalopram on Thalamocortical Glutamatergic Transmission Associated with Serotonin 5-HT7 Receptor
por: Okada, Motohiro, et al.
Publicado: (2021)

Amantadine Combines Astroglial System Xc(−) Activation with Glutamate/NMDA Receptor Inhibition
por: Nakano, Tomosuke, et al.
Publicado: (2019)

Current Limitations and Candidate Potential of 5-HT7 Receptor Antagonism in Psychiatric Pharmacotherapy
por: Okubo, Ruri, et al.
Publicado: (2021)

A Candidate Gliotransmitter, L-β-Aminoisobutyrate, Contributes to Weight Gain and Metabolic Complication Induced by Atypical Antipsychotics
por: Fukuyama, Kouji, et al.
Publicado: (2023)

Enhanced L-β-Aminoisobutyric Acid Is Involved in the Pathophysiology of Effectiveness for Treatment-Resistant Schizophrenia and Adverse Reactions of Clozapine
por: Fukuyama, Kouji, et al.
Publicado: (2023)

A Novel Gliotransmitter, L-β-Aminoisobutyric Acid, Contributes to Pathophysiology of Clinical Efficacies and Adverse Reactions of Clozapine
por: Fukuyama, Kouji, et al.
Publicado: (2023)

Effects of Carbamazepine, Lacosamide and Zonisamide on Gliotransmitter Release Associated with Activated Astroglial Hemichannels
por: Fukuyama, Kouji, et al.
Publicado: (2020)

Brivaracetam and Levetiracetam Suppress Astroglial L-Glutamate Release through Hemichannel via Inhibition of Synaptic Vesicle Protein
por: Fukuyama, Kouji, et al.
Publicado: (2022)

Distinct Effects of Escitalopram and Vortioxetine on Astroglial L-Glutamate Release Associated with Connexin43
por: Shiroyama, Takashi, et al.
Publicado: (2021)

Astroglial Connexin43 as a Potential Target for a Mood Stabiliser
por: Okada, Motohiro, et al.
Publicado: (2020)

Effects of an Atypical Antipsychotic, Zotepine, on Astroglial L-Glutamate Release through Hemichannels: Exploring the Mechanism of Mood-Stabilising Antipsychotic Actions and Antipsychotic-Induced Convulsion
por: Fukuyama, Kouji, et al.
Publicado: (2021)

Carbamazepine Attenuates Astroglial L-Glutamate Release Induced by Pro-Inflammatory Cytokines via Chronically Activation of Adenosine A(2A) Receptor
por: Okada, Motohiro, et al.
Publicado: (2019)

Activation of Astroglial Connexin Is Involved in Concentration-Dependent Double-Edged Sword Clinical Action of Clozapine
por: Fukuyama, Kouji, et al.
Publicado: (2020)

Candidate Strategies for Development of a Rapid-Acting Antidepressant Class That Does Not Result in Neuropsychiatric Adverse Effects: Prevention of Ketamine-Induced Neuropsychiatric Adverse Reactions
por: Okada, Motohiro, et al.
Publicado: (2020)

Determining What Changed Japanese Suicide Mortality in 2020 Using Governmental Database
por: Matsumoto, Ryusuke, et al.
Publicado: (2021)

Interaction between Mesocortical and Mesothalamic Catecholaminergic Transmissions Associated with NMDA Receptor in the Locus Coeruleus
por: Okada, Motohiro, et al.
Publicado: (2020)

Memantine protects thalamocortical hyper‐glutamatergic transmission induced by NMDA receptor antagonism via activation of system xc(−)
por: Okada, Motohiro, et al.
Publicado: (2019)

Cystine/Glutamate Antiporter and Aripiprazole Compensate NMDA Antagonist-Induced Dysfunction of Thalamocortical L-Glutamatergic Transmission
por: Fukuyama, Kouji, et al.
Publicado: (2018)

Clozapine Normalizes a Glutamatergic Transmission Abnormality Induced by an Impaired NMDA Receptor in the Thalamocortical Pathway via the Activation of a Group III Metabotropic Glutamate Receptor
por: Fukuyama, Kouji, et al.
Publicado: (2019)

Chronic Administrations of Guanfacine on Mesocortical Catecholaminergic and Thalamocortical Glutamatergic Transmissions
por: Fukuyama, Kouji, et al.
Publicado: (2021)

Pharmacological Discrimination of Effects of MK801 on Thalamocortical, Mesothalamic, and Mesocortical Transmissions
por: Okada, Motohiro, et al.
Publicado: (2019)

Upregulated Connexin 43 Induced by Loss-of-Functional S284L-Mutant α4 Subunit of Nicotinic ACh Receptor Contributes to Pathomechanisms of Autosomal Dominant Sleep-Related Hypermotor Epilepsy
por: Fukuyama, Kouji, et al.
Publicado: (2020)

O7.5. LONG-TERM SAFETY AND TOLERABILITY OF BREXPIPRAZOLE IN PATIENTS WITH SCHIZOPHRENIA
por: Hakala, Mika, et al.
Publicado: (2018)

Upregulated and Hyperactivated Thalamic Connexin 43 Plays Important Roles in Pathomechanisms of Cognitive Impairment and Seizure of Autosomal Dominant Sleep-Related Hypermotor Epilepsy with S284L-Mutant α4 Subunit of Nicotinic ACh Receptor
por: Fukuyama, Kouji, et al.
Publicado: (2020)

Impacts of Complete Unemployment Rates Disaggregated by Reason and Duration on Suicide Mortality from 2009–2022 in Japan
por: Matsumoto, Ryusuke, et al.
Publicado: (2023)

Age-Dependent and Sleep/Seizure-Induced Pathomechanisms of Autosomal Dominant Sleep-Related Hypermotor Epilepsy
por: Fukuyama, Kouji, et al.
Publicado: (2020)

Distribution of 5-HT(3), 5-HT(4), and 5-HT(7) Receptors Along the Human Colon
por: Yaakob, Nor S, et al.
Publicado: (2015)

Brexpiprazole has a low risk of dopamine D(2) receptor sensitization and inhibits rebound phenomena related to D(2) and serotonin 5‐HT(2A) receptors in rats
por: Amada, Naoki, et al.
Publicado: (2019)

Effects of Magnitude of Leading Stimulus on Prepulse Inhibition of Auditory Evoked Cerebral Responses: An Exploratory Study
por: Kawano, Yasuhiro, et al.
Publicado: (2021)

Suicidal Mortality and Motives Among Middle-School, High-School, and University Students
por: Okada, Motohiro, et al.
Publicado: (2023)

Review: 5-HT(1), 5-HT(2), 5-HT(3) and 5-HT(7) Receptors and their Role in the Modulation of Pain Response in the Central Nervous System
por: Cortes-Altamirano, Jose Luis, et al.
Publicado: (2018)

Effects of Financial Expenditure of Prefectures/Municipalities on Regional Suicide Mortality in Japan
por: Shiroyama, Takashi, et al.
Publicado: (2021)

Relationships between Expenditure of Regional Governments and Suicide Mortalities Caused by Six Major Motives in Japan
por: Hasegawa, Toshiki, et al.
Publicado: (2021)

Human 5–HT(4) and 5–HT(7) Receptor Splice Variants: Are they Important?
por: Coupar, Ian M, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_go8b4ml3ci2ndgc8lc8ahpenfi