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Pharmacotherapy of Itch—Antihistamines and Histamine Receptors as G Protein-Coupled Receptors

Itching can decrease quality of life and exacerbate skin symptoms due to scratching. Itching not only contributes to disease progression but also triggers complications such as skin infections and eye symptoms. Therefore, controlling itching is very important in therapeutic management. In addition t...

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Autores principales: Fukasawa, Takemichi, Yoshizaki-Ogawa, Asako, Enomoto, Atsushi, Miyagawa, Kiyoshi, Sato, Shinichi, Yoshizaki, Ayumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223628/
https://www.ncbi.nlm.nih.gov/pubmed/35743023
http://dx.doi.org/10.3390/ijms23126579
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author Fukasawa, Takemichi
Yoshizaki-Ogawa, Asako
Enomoto, Atsushi
Miyagawa, Kiyoshi
Sato, Shinichi
Yoshizaki, Ayumi
author_facet Fukasawa, Takemichi
Yoshizaki-Ogawa, Asako
Enomoto, Atsushi
Miyagawa, Kiyoshi
Sato, Shinichi
Yoshizaki, Ayumi
author_sort Fukasawa, Takemichi
collection PubMed
description Itching can decrease quality of life and exacerbate skin symptoms due to scratching. Itching not only contributes to disease progression but also triggers complications such as skin infections and eye symptoms. Therefore, controlling itching is very important in therapeutic management. In addition to the well-known histamine, IL-31, IL-4 and IL-13 have recently been reported as factors that induce itching. Itching may also be caused by factors other than these histamines. However, we do not know the extent to which these factors are involved in each disease. In addition, the degree of involvement is likely to vary among individuals. To date, antihistamines have been widely used to treat itching and are often effective, suggesting that histamine is more or less involved in itchy diseases. This review discusses the ligand-receptor perspective and describes the dynamics of G protein-coupled receptors, their role as biased agonists, their role as inverse agonists, proactive antihistamine therapy, and drug selection with consideration of impaired performance and anti-PAF effects.
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spelling pubmed-92236282022-06-24 Pharmacotherapy of Itch—Antihistamines and Histamine Receptors as G Protein-Coupled Receptors Fukasawa, Takemichi Yoshizaki-Ogawa, Asako Enomoto, Atsushi Miyagawa, Kiyoshi Sato, Shinichi Yoshizaki, Ayumi Int J Mol Sci Review Itching can decrease quality of life and exacerbate skin symptoms due to scratching. Itching not only contributes to disease progression but also triggers complications such as skin infections and eye symptoms. Therefore, controlling itching is very important in therapeutic management. In addition to the well-known histamine, IL-31, IL-4 and IL-13 have recently been reported as factors that induce itching. Itching may also be caused by factors other than these histamines. However, we do not know the extent to which these factors are involved in each disease. In addition, the degree of involvement is likely to vary among individuals. To date, antihistamines have been widely used to treat itching and are often effective, suggesting that histamine is more or less involved in itchy diseases. This review discusses the ligand-receptor perspective and describes the dynamics of G protein-coupled receptors, their role as biased agonists, their role as inverse agonists, proactive antihistamine therapy, and drug selection with consideration of impaired performance and anti-PAF effects. MDPI 2022-06-13 /pmc/articles/PMC9223628/ /pubmed/35743023 http://dx.doi.org/10.3390/ijms23126579 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fukasawa, Takemichi
Yoshizaki-Ogawa, Asako
Enomoto, Atsushi
Miyagawa, Kiyoshi
Sato, Shinichi
Yoshizaki, Ayumi
Pharmacotherapy of Itch—Antihistamines and Histamine Receptors as G Protein-Coupled Receptors
title Pharmacotherapy of Itch—Antihistamines and Histamine Receptors as G Protein-Coupled Receptors
title_full Pharmacotherapy of Itch—Antihistamines and Histamine Receptors as G Protein-Coupled Receptors
title_fullStr Pharmacotherapy of Itch—Antihistamines and Histamine Receptors as G Protein-Coupled Receptors
title_full_unstemmed Pharmacotherapy of Itch—Antihistamines and Histamine Receptors as G Protein-Coupled Receptors
title_short Pharmacotherapy of Itch—Antihistamines and Histamine Receptors as G Protein-Coupled Receptors
title_sort pharmacotherapy of itch—antihistamines and histamine receptors as g protein-coupled receptors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223628/
https://www.ncbi.nlm.nih.gov/pubmed/35743023
http://dx.doi.org/10.3390/ijms23126579
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