Harnessing the B Cell Response in Kidney Transplantation – Current State and Future Directions

Despite dramatic improvement in kidney transplantation outcomes over the last decades due to advent of modern immunosuppressive agents, long-term outcomes remain poor. Antibody-mediated rejection (ABMR), a B cell driven process, accounts for the majority of chronic graft failures. There are currentl...

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Autores principales: Anwar, Imran J., DeLaura, Isabel F., Gao, Qimeng, Ladowski, Joseph, Jackson, Annette M., Kwun, Jean, Knechtle, Stuart J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223638/
https://www.ncbi.nlm.nih.gov/pubmed/35757745
http://dx.doi.org/10.3389/fimmu.2022.903068
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author Anwar, Imran J.
DeLaura, Isabel F.
Gao, Qimeng
Ladowski, Joseph
Jackson, Annette M.
Kwun, Jean
Knechtle, Stuart J.
author_facet Anwar, Imran J.
DeLaura, Isabel F.
Gao, Qimeng
Ladowski, Joseph
Jackson, Annette M.
Kwun, Jean
Knechtle, Stuart J.
author_sort Anwar, Imran J.
collection PubMed
description Despite dramatic improvement in kidney transplantation outcomes over the last decades due to advent of modern immunosuppressive agents, long-term outcomes remain poor. Antibody-mediated rejection (ABMR), a B cell driven process, accounts for the majority of chronic graft failures. There are currently no FDA-approved regimens for ABMR; however, several clinical trials are currently on-going. In this review, we present current mechanisms of B cell response in kidney transplantation, the clinical impact of sensitization and ABMR, the B cell response under current immunosuppressive regimens, and ongoing clinical trials for ABMR and desensitization treatment.
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spelling pubmed-92236382022-06-24 Harnessing the B Cell Response in Kidney Transplantation – Current State and Future Directions Anwar, Imran J. DeLaura, Isabel F. Gao, Qimeng Ladowski, Joseph Jackson, Annette M. Kwun, Jean Knechtle, Stuart J. Front Immunol Immunology Despite dramatic improvement in kidney transplantation outcomes over the last decades due to advent of modern immunosuppressive agents, long-term outcomes remain poor. Antibody-mediated rejection (ABMR), a B cell driven process, accounts for the majority of chronic graft failures. There are currently no FDA-approved regimens for ABMR; however, several clinical trials are currently on-going. In this review, we present current mechanisms of B cell response in kidney transplantation, the clinical impact of sensitization and ABMR, the B cell response under current immunosuppressive regimens, and ongoing clinical trials for ABMR and desensitization treatment. Frontiers Media S.A. 2022-06-09 /pmc/articles/PMC9223638/ /pubmed/35757745 http://dx.doi.org/10.3389/fimmu.2022.903068 Text en Copyright © 2022 Anwar, DeLaura, Gao, Ladowski, Jackson, Kwun and Knechtle https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Anwar, Imran J.
DeLaura, Isabel F.
Gao, Qimeng
Ladowski, Joseph
Jackson, Annette M.
Kwun, Jean
Knechtle, Stuart J.
Harnessing the B Cell Response in Kidney Transplantation – Current State and Future Directions
title Harnessing the B Cell Response in Kidney Transplantation – Current State and Future Directions
title_full Harnessing the B Cell Response in Kidney Transplantation – Current State and Future Directions
title_fullStr Harnessing the B Cell Response in Kidney Transplantation – Current State and Future Directions
title_full_unstemmed Harnessing the B Cell Response in Kidney Transplantation – Current State and Future Directions
title_short Harnessing the B Cell Response in Kidney Transplantation – Current State and Future Directions
title_sort harnessing the b cell response in kidney transplantation – current state and future directions
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223638/
https://www.ncbi.nlm.nih.gov/pubmed/35757745
http://dx.doi.org/10.3389/fimmu.2022.903068
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