In Vitro Selection and Characterization of HIV-1 Variants with Increased Resistance to LP-40, Enfuvirtide-Based Lipopeptide Inhibitor

In our previous work, we replaced the TRM (tryptophan-rich motif) of T20 (Enfuvirtide) with fatty acid (C16) to obtain the novel lipopeptide LP-40, and LP-40 displayed enhanced antiviral activity. In this study, we investigated whether the C16 modification could enhance the high-resistance barrier o...

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Detalles Bibliográficos
Autores principales: Hu, Yue, Yu, Wenjiang, Geng, Xiuzhu, Zhu, Yuanmei, Chong, Huihui, He, Yuxian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223764/
https://www.ncbi.nlm.nih.gov/pubmed/35743078
http://dx.doi.org/10.3390/ijms23126638

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223764/
https://www.ncbi.nlm.nih.gov/pubmed/35743078
http://dx.doi.org/10.3390/ijms23126638

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