Col4a3(-/-) Mice on Balb/C Background Have Less Severe Cardiorespiratory Phenotype and SGLT2 Over-Expression Compared to 129x1/SvJ and C57Bl/6 Backgrounds

Alport syndrome (AS) is a hereditary renal disorder with no etiological therapy. In the preclinical Col4a3(-/-) model of AS, disease progression and severity vary depending on mouse strain. The sodium-glucose cotransporter 2 (SGLT2) is emerging as an attractive therapeutic target in cardiac/renal pa...

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Detalles Bibliográficos
Autores principales: Irion, Camila I., Williams, Monique, Capcha, Jose Condor, Eisenberg, Trevor, Lambert, Guerline, Takeuchi, Lauro M., Seo, Grace, Yousefi, Keyvan, Kanashiro-Takeuchi, Rosemeire, Webster, Keith A., Young, Karen C., Hare, Joshua M., Shehadeh, Lina A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223785/
https://www.ncbi.nlm.nih.gov/pubmed/35743114
http://dx.doi.org/10.3390/ijms23126674

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