NMDA and P2X7 Receptors Require Pannexin 1 Activation to Initiate and Maintain Nociceptive Signaling in the Spinal Cord of Neuropathic Rats

Pannexin 1 (Panx1) is involved in the spinal central sensitization process in rats with neuropathic pain, but its interaction with well-known, pain-related, ligand-dependent receptors, such as NMDA receptors (NMDAR) and P2X7 purinoceptors (P2X7R), remains largely unexplored. Here, we studied whether...

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Detalles Bibliográficos
Autores principales: Bravo, David, Zepeda-Morales, Katherine, Maturana, Carola J., Retamal, Jeffri S., Hernández, Alejandro, Pelissier, Teresa, Barra, Rafael, Sáez-Briones, Patricio, Burgos, Héctor, Constandil, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223805/
https://www.ncbi.nlm.nih.gov/pubmed/35743148
http://dx.doi.org/10.3390/ijms23126705

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