Inactivation of Osteoblast PKC Signaling Reduces Cortical Bone Mass and Density and Aggravates Renal Osteodystrophy in Mice with Chronic Kidney Disease on High Phosphate Diet

Chronic kidney disease (CKD) frequently leads to hyperphosphatemia and hyperparathyroidism, mineral bone disorder (CKD-MBD), ectopic calcifications and cardiovascular mortality. PTH activates the osteoanabolic Gα(s)/PKA and the Gα(q/11)/PKC pathways in osteoblasts, the specific impact of the latter...

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Detalles Bibliográficos
Autores principales: Zaloszyc, Ariane, Choquet, Philippe, Sayeh, Amira, Bartosova, Maria, Schaefer, Betti, Huegel, Ulrike, Aubertin-Kirch, Gaëlle, Healy, Christopher, Severac, François, Rizzo, Sébastien, Boivin, Georges, Schaefer, Franz, Fischbach, Michel, Bacchetta, Justine, Bahram, Seiamak, Schmitt, Claus Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223847/
https://www.ncbi.nlm.nih.gov/pubmed/35742850
http://dx.doi.org/10.3390/ijms23126404

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223847/
https://www.ncbi.nlm.nih.gov/pubmed/35742850
http://dx.doi.org/10.3390/ijms23126404

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