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Dietary Copper Deficiency Leads to Changes in Gene Expression Indicating an Increased Demand for NADH in the Prefrontal Cortex of the Rat’s Brain

Copper is an essential element to brain cells as it is a cofactor and a structural component of various enzymes involved in energy metabolism pathways. Accumulating evidence points to the pivotal role of copper deficiency in neurodegeneration resulting from impaired copper homeostasis. Despite the i...

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Autores principales: Cendrowska-Pinkosz, Monika, Ostrowska-Lesko, Marta, Ognik, Katarzyna, Krauze, Magdalena, Juskiewicz, Jerzy, Dabrowska, Anna, Szponar, Jaroslaw, Mandziuk, Slawomir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224161/
https://www.ncbi.nlm.nih.gov/pubmed/35743150
http://dx.doi.org/10.3390/ijms23126706
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author Cendrowska-Pinkosz, Monika
Ostrowska-Lesko, Marta
Ognik, Katarzyna
Krauze, Magdalena
Juskiewicz, Jerzy
Dabrowska, Anna
Szponar, Jaroslaw
Mandziuk, Slawomir
author_facet Cendrowska-Pinkosz, Monika
Ostrowska-Lesko, Marta
Ognik, Katarzyna
Krauze, Magdalena
Juskiewicz, Jerzy
Dabrowska, Anna
Szponar, Jaroslaw
Mandziuk, Slawomir
author_sort Cendrowska-Pinkosz, Monika
collection PubMed
description Copper is an essential element to brain cells as it is a cofactor and a structural component of various enzymes involved in energy metabolism pathways. Accumulating evidence points to the pivotal role of copper deficiency in neurodegeneration resulting from impaired copper homeostasis. Despite the indisputable role of copper in mitochondrial respiration, its homeostasis regulation in the brain tissue remains unclear. The assessment of changes in the expression of genes encoding key pathways of energy metabolism can greatly benefit further studies exploring copper’s role in neurodegeneration. Using a rat model, we investigate whether the replacement of the inorganic form of copper with metallic nanoparticles containing copper or complete deprivation of copper from the diet have an impact on the expression of genes involved in energy metabolism in the prefrontal cortex of the rats’ brain. Herein, we indicate that removing inorganic copper from the normal standard diet or the replacement with copper nanoparticles can lead to programmed energy metabolism changes. It can be recognized that some of these changes indicate an increased demand for NADH in the prefrontal cortex of the rat’s brain, probably as a result of adaptation effect.
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spelling pubmed-92241612022-06-24 Dietary Copper Deficiency Leads to Changes in Gene Expression Indicating an Increased Demand for NADH in the Prefrontal Cortex of the Rat’s Brain Cendrowska-Pinkosz, Monika Ostrowska-Lesko, Marta Ognik, Katarzyna Krauze, Magdalena Juskiewicz, Jerzy Dabrowska, Anna Szponar, Jaroslaw Mandziuk, Slawomir Int J Mol Sci Article Copper is an essential element to brain cells as it is a cofactor and a structural component of various enzymes involved in energy metabolism pathways. Accumulating evidence points to the pivotal role of copper deficiency in neurodegeneration resulting from impaired copper homeostasis. Despite the indisputable role of copper in mitochondrial respiration, its homeostasis regulation in the brain tissue remains unclear. The assessment of changes in the expression of genes encoding key pathways of energy metabolism can greatly benefit further studies exploring copper’s role in neurodegeneration. Using a rat model, we investigate whether the replacement of the inorganic form of copper with metallic nanoparticles containing copper or complete deprivation of copper from the diet have an impact on the expression of genes involved in energy metabolism in the prefrontal cortex of the rats’ brain. Herein, we indicate that removing inorganic copper from the normal standard diet or the replacement with copper nanoparticles can lead to programmed energy metabolism changes. It can be recognized that some of these changes indicate an increased demand for NADH in the prefrontal cortex of the rat’s brain, probably as a result of adaptation effect. MDPI 2022-06-16 /pmc/articles/PMC9224161/ /pubmed/35743150 http://dx.doi.org/10.3390/ijms23126706 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cendrowska-Pinkosz, Monika
Ostrowska-Lesko, Marta
Ognik, Katarzyna
Krauze, Magdalena
Juskiewicz, Jerzy
Dabrowska, Anna
Szponar, Jaroslaw
Mandziuk, Slawomir
Dietary Copper Deficiency Leads to Changes in Gene Expression Indicating an Increased Demand for NADH in the Prefrontal Cortex of the Rat’s Brain
title Dietary Copper Deficiency Leads to Changes in Gene Expression Indicating an Increased Demand for NADH in the Prefrontal Cortex of the Rat’s Brain
title_full Dietary Copper Deficiency Leads to Changes in Gene Expression Indicating an Increased Demand for NADH in the Prefrontal Cortex of the Rat’s Brain
title_fullStr Dietary Copper Deficiency Leads to Changes in Gene Expression Indicating an Increased Demand for NADH in the Prefrontal Cortex of the Rat’s Brain
title_full_unstemmed Dietary Copper Deficiency Leads to Changes in Gene Expression Indicating an Increased Demand for NADH in the Prefrontal Cortex of the Rat’s Brain
title_short Dietary Copper Deficiency Leads to Changes in Gene Expression Indicating an Increased Demand for NADH in the Prefrontal Cortex of the Rat’s Brain
title_sort dietary copper deficiency leads to changes in gene expression indicating an increased demand for nadh in the prefrontal cortex of the rat’s brain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224161/
https://www.ncbi.nlm.nih.gov/pubmed/35743150
http://dx.doi.org/10.3390/ijms23126706
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