The Emerging Role of EVA1A in Different Types of Cancers

Eva-1 homolog A (EVA1A), also known as transmembrane protein 166 (TMEM166) and regulator of programmed cell death, is an endoplasmic reticulum associated protein, which can play an important role in many diseases, including a variety of cancers, by regulating autophagy/apoptosis. However, the relate...

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Detalles Bibliográficos
Autores principales: Zhao, Huijie, Liu, Huiyang, Yang, Yihan, Wang, Honggang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224241/
https://www.ncbi.nlm.nih.gov/pubmed/35743108
http://dx.doi.org/10.3390/ijms23126665
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author Zhao, Huijie
Liu, Huiyang
Yang, Yihan
Wang, Honggang
author_facet Zhao, Huijie
Liu, Huiyang
Yang, Yihan
Wang, Honggang
author_sort Zhao, Huijie
collection PubMed
description Eva-1 homolog A (EVA1A), also known as transmembrane protein 166 (TMEM166) and regulator of programmed cell death, is an endoplasmic reticulum associated protein, which can play an important role in many diseases, including a variety of cancers, by regulating autophagy/apoptosis. However, the related mechanism, especially the role of EVA1A in cancers, has not been fully understood. In this review, we summarize the recent studies on the role of EVA1A in different types of cancers, including breast cancer, papillary thyroid cancer, non-small cell lung cancer, hepatocellular carcinoma, glioblastoma and pancreatic cancer, and analyze the relevant mechanisms to provide a theoretical basis for future related research.
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spelling pubmed-92242412022-06-24 The Emerging Role of EVA1A in Different Types of Cancers Zhao, Huijie Liu, Huiyang Yang, Yihan Wang, Honggang Int J Mol Sci Review Eva-1 homolog A (EVA1A), also known as transmembrane protein 166 (TMEM166) and regulator of programmed cell death, is an endoplasmic reticulum associated protein, which can play an important role in many diseases, including a variety of cancers, by regulating autophagy/apoptosis. However, the related mechanism, especially the role of EVA1A in cancers, has not been fully understood. In this review, we summarize the recent studies on the role of EVA1A in different types of cancers, including breast cancer, papillary thyroid cancer, non-small cell lung cancer, hepatocellular carcinoma, glioblastoma and pancreatic cancer, and analyze the relevant mechanisms to provide a theoretical basis for future related research. MDPI 2022-06-15 /pmc/articles/PMC9224241/ /pubmed/35743108 http://dx.doi.org/10.3390/ijms23126665 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhao, Huijie
Liu, Huiyang
Yang, Yihan
Wang, Honggang
The Emerging Role of EVA1A in Different Types of Cancers
title The Emerging Role of EVA1A in Different Types of Cancers
title_full The Emerging Role of EVA1A in Different Types of Cancers
title_fullStr The Emerging Role of EVA1A in Different Types of Cancers
title_full_unstemmed The Emerging Role of EVA1A in Different Types of Cancers
title_short The Emerging Role of EVA1A in Different Types of Cancers
title_sort emerging role of eva1a in different types of cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224241/
https://www.ncbi.nlm.nih.gov/pubmed/35743108
http://dx.doi.org/10.3390/ijms23126665
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