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Kidney-Specific CAP1/Prss8-Deficient Mice Maintain ENaC-Mediated Sodium Balance through an Aldosterone Independent Pathway

The serine protease prostasin (CAP1/Prss8, channel-activating protease-1) is a confirmed in vitro and in vivo activator of the epithelial sodium channel ENaC. To test whether proteolytic activity or CAP1/Prss8 abundance itself are required for ENaC activation in the kidney, we studied animals either...

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Detalles Bibliográficos
Autores principales:	Ehret, Elodie, Jäger, Yannick, Sergi, Chloé, Mérillat, Anne-Marie, Peyrollaz, Thibaud, Anand, Deepika, Wang, Qing, Ino, Fréderique, Maillard, Marc, Kellenberger, Stephan, Gautschi, Ivan, Szabo, Roman, Bugge, Thomas H., Vogel, Lotte K., Hummler, Edith, Frateschi, Simona
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224322/ https://www.ncbi.nlm.nih.gov/pubmed/35743186 http://dx.doi.org/10.3390/ijms23126745

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