Structural and Molecular Kinetic Features of Activities of DNA Polymerases

DNA polymerases catalyze DNA synthesis during the replication, repair, and recombination of DNA. Based on phylogenetic analysis and primary protein sequences, DNA polymerases have been categorized into seven families: A, B, C, D, X, Y, and RT. This review presents generalized data on the catalytic m...

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Detalles Bibliográficos
Autores principales: Kuznetsova, Aleksandra A., Fedorova, Olga S., Kuznetsov, Nikita A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224347/
https://www.ncbi.nlm.nih.gov/pubmed/35742812
http://dx.doi.org/10.3390/ijms23126373
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author Kuznetsova, Aleksandra A.
Fedorova, Olga S.
Kuznetsov, Nikita A.
author_facet Kuznetsova, Aleksandra A.
Fedorova, Olga S.
Kuznetsov, Nikita A.
author_sort Kuznetsova, Aleksandra A.
collection PubMed
description DNA polymerases catalyze DNA synthesis during the replication, repair, and recombination of DNA. Based on phylogenetic analysis and primary protein sequences, DNA polymerases have been categorized into seven families: A, B, C, D, X, Y, and RT. This review presents generalized data on the catalytic mechanism of action of DNA polymerases. The structural features of different DNA polymerase families are described in detail. The discussion highlights the kinetics and conformational dynamics of DNA polymerases from all known polymerase families during DNA synthesis.
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spelling pubmed-92243472022-06-24 Structural and Molecular Kinetic Features of Activities of DNA Polymerases Kuznetsova, Aleksandra A. Fedorova, Olga S. Kuznetsov, Nikita A. Int J Mol Sci Review DNA polymerases catalyze DNA synthesis during the replication, repair, and recombination of DNA. Based on phylogenetic analysis and primary protein sequences, DNA polymerases have been categorized into seven families: A, B, C, D, X, Y, and RT. This review presents generalized data on the catalytic mechanism of action of DNA polymerases. The structural features of different DNA polymerase families are described in detail. The discussion highlights the kinetics and conformational dynamics of DNA polymerases from all known polymerase families during DNA synthesis. MDPI 2022-06-07 /pmc/articles/PMC9224347/ /pubmed/35742812 http://dx.doi.org/10.3390/ijms23126373 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kuznetsova, Aleksandra A.
Fedorova, Olga S.
Kuznetsov, Nikita A.
Structural and Molecular Kinetic Features of Activities of DNA Polymerases
title Structural and Molecular Kinetic Features of Activities of DNA Polymerases
title_full Structural and Molecular Kinetic Features of Activities of DNA Polymerases
title_fullStr Structural and Molecular Kinetic Features of Activities of DNA Polymerases
title_full_unstemmed Structural and Molecular Kinetic Features of Activities of DNA Polymerases
title_short Structural and Molecular Kinetic Features of Activities of DNA Polymerases
title_sort structural and molecular kinetic features of activities of dna polymerases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224347/
https://www.ncbi.nlm.nih.gov/pubmed/35742812
http://dx.doi.org/10.3390/ijms23126373
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