IgG from Adult Atopic Dermatitis (AD) Patients Induces Nonatopic Neonatal Thymic Gamma–Delta T Cells (γδT) to Acquire IL-22/IL-17 Secretion Profile with Skin-Homing Properties and Epigenetic Implications Mediated by miRNA

γδT cells mature in the human thymus, and mainly produce IL-17A or IFN-γ, but can also produce IL-22 and modulate a variety of immune responses. Here, we aimed to evaluate whether IgG from AD patients (AD IgG) can functionally modulate thymic nonatopic γδT cells. Thymic tissues were obtained from 12...

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Detalles Bibliográficos
Autores principales: Fagundes, Beatriz Oliveira, de Sousa, Thamires Rodrigues, Nascimento, Andrezza, Fernandes, Lorena Abreu, Sgnotto, Fábio da Ressureição, Orfali, Raquel Leão, Aoki, Valéria, Duarte, Alberto José da Silva, Sanabani, Sabri Saeed, Victor, Jefferson Russo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224404/
https://www.ncbi.nlm.nih.gov/pubmed/35743310
http://dx.doi.org/10.3390/ijms23126872

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