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Allicin as a Volatile or Nebulisable Antimycotic for the Treatment of Pulmonary Mycoses: In Vitro Studies Using a Lung Flow Test Rig
Fungal infections of the lung are an increasing problem worldwide and the search for novel therapeutic agents is a current challenge due to emerging resistance to current antimycotics. The volatile defence substance allicin is formed naturally by freshly injured garlic plants and exhibits broad anti...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224539/ https://www.ncbi.nlm.nih.gov/pubmed/35743050 http://dx.doi.org/10.3390/ijms23126607 |
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author | Schier, Christina Foerster (née Reiter), Jana Heupel, Monika Dörner, Philipp Klaas, Michael Schröder, Wolfgang Rink, Lothar Slusarenko, Alan J. Gruhlke, Martin C. H. |
author_facet | Schier, Christina Foerster (née Reiter), Jana Heupel, Monika Dörner, Philipp Klaas, Michael Schröder, Wolfgang Rink, Lothar Slusarenko, Alan J. Gruhlke, Martin C. H. |
author_sort | Schier, Christina |
collection | PubMed |
description | Fungal infections of the lung are an increasing problem worldwide and the search for novel therapeutic agents is a current challenge due to emerging resistance to current antimycotics. The volatile defence substance allicin is formed naturally by freshly injured garlic plants and exhibits broad antimicrobial potency. Chemically synthesised allicin was active against selected fungi upon direct contact and via the gas phase at comparable concentrations to the pharmaceutically used antimycotic amphotericin B. We investigated the suppression of fungal growth by allicin vapour and aerosols in vitro in a test rig at air flow conditions mimicking the human lung. The effect of allicin via the gas phase was enhanced by ethanol. Our results suggest that allicin is a potential candidate for development for use in antifungal therapy for lung and upper respiratory tract infections. |
format | Online Article Text |
id | pubmed-9224539 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92245392022-06-24 Allicin as a Volatile or Nebulisable Antimycotic for the Treatment of Pulmonary Mycoses: In Vitro Studies Using a Lung Flow Test Rig Schier, Christina Foerster (née Reiter), Jana Heupel, Monika Dörner, Philipp Klaas, Michael Schröder, Wolfgang Rink, Lothar Slusarenko, Alan J. Gruhlke, Martin C. H. Int J Mol Sci Article Fungal infections of the lung are an increasing problem worldwide and the search for novel therapeutic agents is a current challenge due to emerging resistance to current antimycotics. The volatile defence substance allicin is formed naturally by freshly injured garlic plants and exhibits broad antimicrobial potency. Chemically synthesised allicin was active against selected fungi upon direct contact and via the gas phase at comparable concentrations to the pharmaceutically used antimycotic amphotericin B. We investigated the suppression of fungal growth by allicin vapour and aerosols in vitro in a test rig at air flow conditions mimicking the human lung. The effect of allicin via the gas phase was enhanced by ethanol. Our results suggest that allicin is a potential candidate for development for use in antifungal therapy for lung and upper respiratory tract infections. MDPI 2022-06-14 /pmc/articles/PMC9224539/ /pubmed/35743050 http://dx.doi.org/10.3390/ijms23126607 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Schier, Christina Foerster (née Reiter), Jana Heupel, Monika Dörner, Philipp Klaas, Michael Schröder, Wolfgang Rink, Lothar Slusarenko, Alan J. Gruhlke, Martin C. H. Allicin as a Volatile or Nebulisable Antimycotic for the Treatment of Pulmonary Mycoses: In Vitro Studies Using a Lung Flow Test Rig |
title | Allicin as a Volatile or Nebulisable Antimycotic for the Treatment of Pulmonary Mycoses: In Vitro Studies Using a Lung Flow Test Rig |
title_full | Allicin as a Volatile or Nebulisable Antimycotic for the Treatment of Pulmonary Mycoses: In Vitro Studies Using a Lung Flow Test Rig |
title_fullStr | Allicin as a Volatile or Nebulisable Antimycotic for the Treatment of Pulmonary Mycoses: In Vitro Studies Using a Lung Flow Test Rig |
title_full_unstemmed | Allicin as a Volatile or Nebulisable Antimycotic for the Treatment of Pulmonary Mycoses: In Vitro Studies Using a Lung Flow Test Rig |
title_short | Allicin as a Volatile or Nebulisable Antimycotic for the Treatment of Pulmonary Mycoses: In Vitro Studies Using a Lung Flow Test Rig |
title_sort | allicin as a volatile or nebulisable antimycotic for the treatment of pulmonary mycoses: in vitro studies using a lung flow test rig |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224539/ https://www.ncbi.nlm.nih.gov/pubmed/35743050 http://dx.doi.org/10.3390/ijms23126607 |
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