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Prognostic Significance of Perineural Invasion in Patients with Stage II/III Gastric Cancer Undergoing Radical Surgery

The prognostic significance of perineural invasion in patients with gastric cancer (GC) is controversial. This study aimed to determine the prognostic value of perineural invasion in patients with stage II/III GC undergoing radical surgery. A total of 1913 patients with stage II/III GC who underwent...

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Autores principales: Chen, Yi-Fu, Wang, Shan-Yu, Le, Puo-Hsien, Chen, Tsung-Hsing, Kuo, Chia-Jung, Lin, Chun-Jung, Chou, Wen-Chi, Yeh, Ta-Sen, Hsu, Jun-Te
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224547/
https://www.ncbi.nlm.nih.gov/pubmed/35743747
http://dx.doi.org/10.3390/jpm12060962
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author Chen, Yi-Fu
Wang, Shan-Yu
Le, Puo-Hsien
Chen, Tsung-Hsing
Kuo, Chia-Jung
Lin, Chun-Jung
Chou, Wen-Chi
Yeh, Ta-Sen
Hsu, Jun-Te
author_facet Chen, Yi-Fu
Wang, Shan-Yu
Le, Puo-Hsien
Chen, Tsung-Hsing
Kuo, Chia-Jung
Lin, Chun-Jung
Chou, Wen-Chi
Yeh, Ta-Sen
Hsu, Jun-Te
author_sort Chen, Yi-Fu
collection PubMed
description The prognostic significance of perineural invasion in patients with gastric cancer (GC) is controversial. This study aimed to determine the prognostic value of perineural invasion in patients with stage II/III GC undergoing radical surgery. A total of 1913 patients with stage II/III GC who underwent curative resection between 1994 and 2015 were recruited. Clinicopathological factors, tumor recurrence patterns, disease-free survival, and cancer-specific survival were compared in terms of perineural invasion. The prognostic factors of disease-free survival and cancer-specific survival were determined using univariate and multivariate analyses. Perineural invasion was found in 57.1% of the patients. Age of <65 years, female sex, large tumor size, upper tumor location, total gastrectomy, advanced tumor invasion depth and nodal involvement, greater metastatic to examined lymph node ratio, undifferentiated tumor, and presence of lymphatic or vascular invasion were significantly associated with perineural invasion. The patients with perineural invasion had higher locoregional/peritoneal recurrence rates than those without. Perineural invasion was independently associated with disease-free survival and cancer-specific survival. In conclusion, perineural invasion positivity is associated with aggressive tumor behaviors and higher locoregional/peritoneal recurrence rates in patients with stage II/III GC undergoing curative surgery. It is an independent unfavorable prognostic factor of disease recurrence and cancer-specific survival.
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spelling pubmed-92245472022-06-24 Prognostic Significance of Perineural Invasion in Patients with Stage II/III Gastric Cancer Undergoing Radical Surgery Chen, Yi-Fu Wang, Shan-Yu Le, Puo-Hsien Chen, Tsung-Hsing Kuo, Chia-Jung Lin, Chun-Jung Chou, Wen-Chi Yeh, Ta-Sen Hsu, Jun-Te J Pers Med Article The prognostic significance of perineural invasion in patients with gastric cancer (GC) is controversial. This study aimed to determine the prognostic value of perineural invasion in patients with stage II/III GC undergoing radical surgery. A total of 1913 patients with stage II/III GC who underwent curative resection between 1994 and 2015 were recruited. Clinicopathological factors, tumor recurrence patterns, disease-free survival, and cancer-specific survival were compared in terms of perineural invasion. The prognostic factors of disease-free survival and cancer-specific survival were determined using univariate and multivariate analyses. Perineural invasion was found in 57.1% of the patients. Age of <65 years, female sex, large tumor size, upper tumor location, total gastrectomy, advanced tumor invasion depth and nodal involvement, greater metastatic to examined lymph node ratio, undifferentiated tumor, and presence of lymphatic or vascular invasion were significantly associated with perineural invasion. The patients with perineural invasion had higher locoregional/peritoneal recurrence rates than those without. Perineural invasion was independently associated with disease-free survival and cancer-specific survival. In conclusion, perineural invasion positivity is associated with aggressive tumor behaviors and higher locoregional/peritoneal recurrence rates in patients with stage II/III GC undergoing curative surgery. It is an independent unfavorable prognostic factor of disease recurrence and cancer-specific survival. MDPI 2022-06-12 /pmc/articles/PMC9224547/ /pubmed/35743747 http://dx.doi.org/10.3390/jpm12060962 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Yi-Fu
Wang, Shan-Yu
Le, Puo-Hsien
Chen, Tsung-Hsing
Kuo, Chia-Jung
Lin, Chun-Jung
Chou, Wen-Chi
Yeh, Ta-Sen
Hsu, Jun-Te
Prognostic Significance of Perineural Invasion in Patients with Stage II/III Gastric Cancer Undergoing Radical Surgery
title Prognostic Significance of Perineural Invasion in Patients with Stage II/III Gastric Cancer Undergoing Radical Surgery
title_full Prognostic Significance of Perineural Invasion in Patients with Stage II/III Gastric Cancer Undergoing Radical Surgery
title_fullStr Prognostic Significance of Perineural Invasion in Patients with Stage II/III Gastric Cancer Undergoing Radical Surgery
title_full_unstemmed Prognostic Significance of Perineural Invasion in Patients with Stage II/III Gastric Cancer Undergoing Radical Surgery
title_short Prognostic Significance of Perineural Invasion in Patients with Stage II/III Gastric Cancer Undergoing Radical Surgery
title_sort prognostic significance of perineural invasion in patients with stage ii/iii gastric cancer undergoing radical surgery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224547/
https://www.ncbi.nlm.nih.gov/pubmed/35743747
http://dx.doi.org/10.3390/jpm12060962
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