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Experience of Combined Procedure during Percutaneous LAA Closure

Introduction: Percutaneous left atrial appendage closure (LAAC) is an alternative to oral anticoagulants (OAC) in patients with non-valvular atrial fibrillation (AF) and contraindication to long-term OAC. Combined strategy with percutaneous LAAC at the same time of other cardiac structural or electr...

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Autores principales: Domain, Guillaume, Dognin, Nicolas, O’Hara, Gilles, Rodès-Cabau, Josep, Paradis, Jean-Michel, Strubé, Camille, Bernier, Mathieu, O’Connor, Kim, Beaudoin, Jonathan, Philippon, François, Salaun, Erwan, Champagne, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224581/
https://www.ncbi.nlm.nih.gov/pubmed/35743351
http://dx.doi.org/10.3390/jcm11123280
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author Domain, Guillaume
Dognin, Nicolas
O’Hara, Gilles
Rodès-Cabau, Josep
Paradis, Jean-Michel
Strubé, Camille
Bernier, Mathieu
O’Connor, Kim
Beaudoin, Jonathan
Philippon, François
Salaun, Erwan
Champagne, Jean
author_facet Domain, Guillaume
Dognin, Nicolas
O’Hara, Gilles
Rodès-Cabau, Josep
Paradis, Jean-Michel
Strubé, Camille
Bernier, Mathieu
O’Connor, Kim
Beaudoin, Jonathan
Philippon, François
Salaun, Erwan
Champagne, Jean
author_sort Domain, Guillaume
collection PubMed
description Introduction: Percutaneous left atrial appendage closure (LAAC) is an alternative to oral anticoagulants (OAC) in patients with non-valvular atrial fibrillation (AF) and contraindication to long-term OAC. Combined strategy with percutaneous LAAC at the same time of other cardiac structural or electrophysiological procedures has emerged as an alternative to a staged strategy. Aim: To describe our experience with combined LAAC procedures using Watchman™ devices. Methods: All patients with combined LAAC procedures using Watchman™ (WN) devices performed from 2016 to 2021 were included. The primary safety endpoint was a composite of periprocedural complications and adverse events during the follow-up. The primary efficacy endpoint included strokes, systemic embolisms, major bleeding and cardiovascular death. Results: From 2016, among 160 patients who underwent LAAC using WN devices, 19 underwent a combined strategy: 7 transcatheter edge-to-edge mitral valve repair (TEMVR) (37%), 6 typical atrial flutter ablation (31%), 2 leadless pacemaker (LP) implantation (10%) and 4 AF ablation (22%). The WN device was successfully implanted in 98% and 100% of cases for single and combined LAAC procedures, respectively (p = 0.63). Median follow-up was 13 months (IQR 25/75 3/24). Device-related complications occurred in 6 out of 141 patients (4%) who underwent single LAAC and in no (0/19) patient in the combined LAAC procedure (p = ns). The procedural-related complications did not differ significantly between groups (5% vs. 10%, respectively, in the single and combined group, p = 0.1). Conclusion: Combined procedure using the Watchman™ devices and one other structural or electrophysiological procedure appears safe and effective. Larger series are needed to confirm these results.
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spelling pubmed-92245812022-06-24 Experience of Combined Procedure during Percutaneous LAA Closure Domain, Guillaume Dognin, Nicolas O’Hara, Gilles Rodès-Cabau, Josep Paradis, Jean-Michel Strubé, Camille Bernier, Mathieu O’Connor, Kim Beaudoin, Jonathan Philippon, François Salaun, Erwan Champagne, Jean J Clin Med Article Introduction: Percutaneous left atrial appendage closure (LAAC) is an alternative to oral anticoagulants (OAC) in patients with non-valvular atrial fibrillation (AF) and contraindication to long-term OAC. Combined strategy with percutaneous LAAC at the same time of other cardiac structural or electrophysiological procedures has emerged as an alternative to a staged strategy. Aim: To describe our experience with combined LAAC procedures using Watchman™ devices. Methods: All patients with combined LAAC procedures using Watchman™ (WN) devices performed from 2016 to 2021 were included. The primary safety endpoint was a composite of periprocedural complications and adverse events during the follow-up. The primary efficacy endpoint included strokes, systemic embolisms, major bleeding and cardiovascular death. Results: From 2016, among 160 patients who underwent LAAC using WN devices, 19 underwent a combined strategy: 7 transcatheter edge-to-edge mitral valve repair (TEMVR) (37%), 6 typical atrial flutter ablation (31%), 2 leadless pacemaker (LP) implantation (10%) and 4 AF ablation (22%). The WN device was successfully implanted in 98% and 100% of cases for single and combined LAAC procedures, respectively (p = 0.63). Median follow-up was 13 months (IQR 25/75 3/24). Device-related complications occurred in 6 out of 141 patients (4%) who underwent single LAAC and in no (0/19) patient in the combined LAAC procedure (p = ns). The procedural-related complications did not differ significantly between groups (5% vs. 10%, respectively, in the single and combined group, p = 0.1). Conclusion: Combined procedure using the Watchman™ devices and one other structural or electrophysiological procedure appears safe and effective. Larger series are needed to confirm these results. MDPI 2022-06-08 /pmc/articles/PMC9224581/ /pubmed/35743351 http://dx.doi.org/10.3390/jcm11123280 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Domain, Guillaume
Dognin, Nicolas
O’Hara, Gilles
Rodès-Cabau, Josep
Paradis, Jean-Michel
Strubé, Camille
Bernier, Mathieu
O’Connor, Kim
Beaudoin, Jonathan
Philippon, François
Salaun, Erwan
Champagne, Jean
Experience of Combined Procedure during Percutaneous LAA Closure
title Experience of Combined Procedure during Percutaneous LAA Closure
title_full Experience of Combined Procedure during Percutaneous LAA Closure
title_fullStr Experience of Combined Procedure during Percutaneous LAA Closure
title_full_unstemmed Experience of Combined Procedure during Percutaneous LAA Closure
title_short Experience of Combined Procedure during Percutaneous LAA Closure
title_sort experience of combined procedure during percutaneous laa closure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224581/
https://www.ncbi.nlm.nih.gov/pubmed/35743351
http://dx.doi.org/10.3390/jcm11123280
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