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Vision-Threatening Ocular Adverse Events after Vaccination against Coronavirus Disease 2019

A single-center retrospective observational case series was conducted. This case series enrolled patients who showed ophthalmic manifestations within one week after COVID-19 vaccination at Korea University Guro Hospital in Seoul, Korea, from May 2021 to January 2022. The medical records of patients...

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Autores principales: Choi, Mihyun, Seo, Min-Hwan, Choi, Kwang-Eon, Lee, Sukyeon, Choi, Boyoon, Yun, Cheolmin, Kim, Seong-Woo, Kim, Yong Yeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224598/
https://www.ncbi.nlm.nih.gov/pubmed/35743388
http://dx.doi.org/10.3390/jcm11123318
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author Choi, Mihyun
Seo, Min-Hwan
Choi, Kwang-Eon
Lee, Sukyeon
Choi, Boyoon
Yun, Cheolmin
Kim, Seong-Woo
Kim, Yong Yeon
author_facet Choi, Mihyun
Seo, Min-Hwan
Choi, Kwang-Eon
Lee, Sukyeon
Choi, Boyoon
Yun, Cheolmin
Kim, Seong-Woo
Kim, Yong Yeon
author_sort Choi, Mihyun
collection PubMed
description A single-center retrospective observational case series was conducted. This case series enrolled patients who showed ophthalmic manifestations within one week after COVID-19 vaccination at Korea University Guro Hospital in Seoul, Korea, from May 2021 to January 2022. The medical records of patients who complained of ocular symptoms and showed ophthalmic adverse events within one week after COVID-19 vaccination were reviewed. Seventeen eyes from 16 patients with a mean age of 63.8 (range 33–83) years were included in the case series, and all symptoms developed within 1–7 days following inoculation. Retinal vein occlusion in nine eyes (52.9%), retinal artery occlusion in one eye (5.9%), newly developed anterior uveitis in one eye (5.9%), exacerbation of previously diagnosed panuveitis in two eyes (11.8%), and angle-closure attack with high intraocular pressure in four eyes (23.5%) were included. Twelve patients (75%) had been vaccinated with the AstraZeneca (AZD1222) and four (25%) with the Pfizer (BNT162b2) vaccines. Of these, 10 patients (62.5%) experienced ocular disease exacerbation after the first dose, 4 (25%) after the second dose, and 2 (12.5%) after the third dose (booster shot). Eleven patients (64.7%) underwent tests for hematological abnormalities, and three of them tested positive for anti-PF4 antibodies, but no abnormal findings were noted. A causal relationship between vaccination and the ocular manifestations could not be determined, which is a limitation of this study. However, clinicians should consider the effect of COVID-19 vaccination on ophthalmic disease. Further studies are required to elucidate the possible effects of COVID-19 vaccination on the eye.
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spelling pubmed-92245982022-06-24 Vision-Threatening Ocular Adverse Events after Vaccination against Coronavirus Disease 2019 Choi, Mihyun Seo, Min-Hwan Choi, Kwang-Eon Lee, Sukyeon Choi, Boyoon Yun, Cheolmin Kim, Seong-Woo Kim, Yong Yeon J Clin Med Article A single-center retrospective observational case series was conducted. This case series enrolled patients who showed ophthalmic manifestations within one week after COVID-19 vaccination at Korea University Guro Hospital in Seoul, Korea, from May 2021 to January 2022. The medical records of patients who complained of ocular symptoms and showed ophthalmic adverse events within one week after COVID-19 vaccination were reviewed. Seventeen eyes from 16 patients with a mean age of 63.8 (range 33–83) years were included in the case series, and all symptoms developed within 1–7 days following inoculation. Retinal vein occlusion in nine eyes (52.9%), retinal artery occlusion in one eye (5.9%), newly developed anterior uveitis in one eye (5.9%), exacerbation of previously diagnosed panuveitis in two eyes (11.8%), and angle-closure attack with high intraocular pressure in four eyes (23.5%) were included. Twelve patients (75%) had been vaccinated with the AstraZeneca (AZD1222) and four (25%) with the Pfizer (BNT162b2) vaccines. Of these, 10 patients (62.5%) experienced ocular disease exacerbation after the first dose, 4 (25%) after the second dose, and 2 (12.5%) after the third dose (booster shot). Eleven patients (64.7%) underwent tests for hematological abnormalities, and three of them tested positive for anti-PF4 antibodies, but no abnormal findings were noted. A causal relationship between vaccination and the ocular manifestations could not be determined, which is a limitation of this study. However, clinicians should consider the effect of COVID-19 vaccination on ophthalmic disease. Further studies are required to elucidate the possible effects of COVID-19 vaccination on the eye. MDPI 2022-06-09 /pmc/articles/PMC9224598/ /pubmed/35743388 http://dx.doi.org/10.3390/jcm11123318 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Choi, Mihyun
Seo, Min-Hwan
Choi, Kwang-Eon
Lee, Sukyeon
Choi, Boyoon
Yun, Cheolmin
Kim, Seong-Woo
Kim, Yong Yeon
Vision-Threatening Ocular Adverse Events after Vaccination against Coronavirus Disease 2019
title Vision-Threatening Ocular Adverse Events after Vaccination against Coronavirus Disease 2019
title_full Vision-Threatening Ocular Adverse Events after Vaccination against Coronavirus Disease 2019
title_fullStr Vision-Threatening Ocular Adverse Events after Vaccination against Coronavirus Disease 2019
title_full_unstemmed Vision-Threatening Ocular Adverse Events after Vaccination against Coronavirus Disease 2019
title_short Vision-Threatening Ocular Adverse Events after Vaccination against Coronavirus Disease 2019
title_sort vision-threatening ocular adverse events after vaccination against coronavirus disease 2019
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224598/
https://www.ncbi.nlm.nih.gov/pubmed/35743388
http://dx.doi.org/10.3390/jcm11123318
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