Generation of TRIM28 Knockout K562 Cells by CRISPR/Cas9 Genome Editing and Characterization of TRIM28-Regulated Gene Expression in Cell Proliferation and Hemoglobin Beta Subunits

TRIM28 is a scaffold protein that interacts with DNA-binding proteins and recruits corepressor complexes to cause gene silencing. TRIM28 contributes to physiological functions such as cell growth and differentiation. In the chronic myeloid leukemia cell line K562, we edited TRIM28 using CRISPR/Cas9...

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Detalles Bibliográficos
Autores principales: Chang, Yao-Jen, Kang, Zhifu, Bei, Jiayuan, Chou, Shu-Jen, Lu, Mei-Yeh Jade, Su, Yu-Lun, Lin, Sheng-Wei, Wang, Hsin-Hui, Lin, Steven, Chang, Ching-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224613/
https://www.ncbi.nlm.nih.gov/pubmed/35743282
http://dx.doi.org/10.3390/ijms23126839

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