The Use of Intravenous Lidocaine in Perioperative Medicine: Anaesthetic, Analgesic and Immune-Modulatory Aspects

This narrative review provides an update on the applied pharmacology of lidocaine, its clinical scope in anaesthesia, novel concepts of analgesic and immune-modulatory effects as well as the current controversy around its use in perioperative opioid-sparing multi-modal strategies. Potential benefits...

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Detalles Bibliográficos
Autores principales: Lee, Ingrid Wing-Sum, Schraag, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224677/
https://www.ncbi.nlm.nih.gov/pubmed/35743617
http://dx.doi.org/10.3390/jcm11123543
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author Lee, Ingrid Wing-Sum
Schraag, Stefan
author_facet Lee, Ingrid Wing-Sum
Schraag, Stefan
author_sort Lee, Ingrid Wing-Sum
collection PubMed
description This narrative review provides an update on the applied pharmacology of lidocaine, its clinical scope in anaesthesia, novel concepts of analgesic and immune-modulatory effects as well as the current controversy around its use in perioperative opioid-sparing multi-modal strategies. Potential benefits of intravenous lidocaine in the context of cancer, inflammation and chronic pain are discussed against concerns of safety, toxicity and medico-legal constraints.
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spelling pubmed-92246772022-06-24 The Use of Intravenous Lidocaine in Perioperative Medicine: Anaesthetic, Analgesic and Immune-Modulatory Aspects Lee, Ingrid Wing-Sum Schraag, Stefan J Clin Med Review This narrative review provides an update on the applied pharmacology of lidocaine, its clinical scope in anaesthesia, novel concepts of analgesic and immune-modulatory effects as well as the current controversy around its use in perioperative opioid-sparing multi-modal strategies. Potential benefits of intravenous lidocaine in the context of cancer, inflammation and chronic pain are discussed against concerns of safety, toxicity and medico-legal constraints. MDPI 2022-06-20 /pmc/articles/PMC9224677/ /pubmed/35743617 http://dx.doi.org/10.3390/jcm11123543 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lee, Ingrid Wing-Sum
Schraag, Stefan
The Use of Intravenous Lidocaine in Perioperative Medicine: Anaesthetic, Analgesic and Immune-Modulatory Aspects
title The Use of Intravenous Lidocaine in Perioperative Medicine: Anaesthetic, Analgesic and Immune-Modulatory Aspects
title_full The Use of Intravenous Lidocaine in Perioperative Medicine: Anaesthetic, Analgesic and Immune-Modulatory Aspects
title_fullStr The Use of Intravenous Lidocaine in Perioperative Medicine: Anaesthetic, Analgesic and Immune-Modulatory Aspects
title_full_unstemmed The Use of Intravenous Lidocaine in Perioperative Medicine: Anaesthetic, Analgesic and Immune-Modulatory Aspects
title_short The Use of Intravenous Lidocaine in Perioperative Medicine: Anaesthetic, Analgesic and Immune-Modulatory Aspects
title_sort use of intravenous lidocaine in perioperative medicine: anaesthetic, analgesic and immune-modulatory aspects
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224677/
https://www.ncbi.nlm.nih.gov/pubmed/35743617
http://dx.doi.org/10.3390/jcm11123543
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