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Using Machine Learning to Detect Theranostic Biomarkers Predicting Respiratory Treatment Response
Background: Theranostic approaches—the use of diagnostics for developing targeted therapies—are gaining popularity in the field of precision medicine. They are predominately used in cancer research, whereas there is little evidence of their use in respiratory medicine. This study aims to detect ther...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224718/ https://www.ncbi.nlm.nih.gov/pubmed/35743805 http://dx.doi.org/10.3390/life12060775 |
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author | Nikolaou, Vasilis Massaro, Sebastiano Fakhimi, Masoud Garn, Wolfgang |
author_facet | Nikolaou, Vasilis Massaro, Sebastiano Fakhimi, Masoud Garn, Wolfgang |
author_sort | Nikolaou, Vasilis |
collection | PubMed |
description | Background: Theranostic approaches—the use of diagnostics for developing targeted therapies—are gaining popularity in the field of precision medicine. They are predominately used in cancer research, whereas there is little evidence of their use in respiratory medicine. This study aims to detect theranostic biomarkers associated with respiratory-treatment responses. This will advance theory and practice on the use of biomarkers in the diagnosis of respiratory diseases and contribute to developing targeted treatments. Methods: We performed a cross-sectional analysis on a sample of 13,102 adults from the UK household longitudinal study ‘Understanding Society’. We used recursive feature selection to identify 16 biomarkers associated with respiratory treatment responses. We then implemented several machine learning algorithms using the identified biomarkers as well as age, sex, body mass index, and lung function to predict treatment response. Results: Our analysis shows that subjects with increased levels of alkaline phosphatase, glycated haemoglobin, high-density lipoprotein cholesterol, c-reactive protein, triglycerides, hemoglobin, and Clauss fibrinogen are more likely to receive respiratory treatments, adjusting for age, sex, body mass index, and lung function. Conclusions: These findings offer a valuable blueprint on why and how the use of biomarkers as diagnostic tools can prove beneficial in guiding treatment management in respiratory diseases. |
format | Online Article Text |
id | pubmed-9224718 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92247182022-06-24 Using Machine Learning to Detect Theranostic Biomarkers Predicting Respiratory Treatment Response Nikolaou, Vasilis Massaro, Sebastiano Fakhimi, Masoud Garn, Wolfgang Life (Basel) Article Background: Theranostic approaches—the use of diagnostics for developing targeted therapies—are gaining popularity in the field of precision medicine. They are predominately used in cancer research, whereas there is little evidence of their use in respiratory medicine. This study aims to detect theranostic biomarkers associated with respiratory-treatment responses. This will advance theory and practice on the use of biomarkers in the diagnosis of respiratory diseases and contribute to developing targeted treatments. Methods: We performed a cross-sectional analysis on a sample of 13,102 adults from the UK household longitudinal study ‘Understanding Society’. We used recursive feature selection to identify 16 biomarkers associated with respiratory treatment responses. We then implemented several machine learning algorithms using the identified biomarkers as well as age, sex, body mass index, and lung function to predict treatment response. Results: Our analysis shows that subjects with increased levels of alkaline phosphatase, glycated haemoglobin, high-density lipoprotein cholesterol, c-reactive protein, triglycerides, hemoglobin, and Clauss fibrinogen are more likely to receive respiratory treatments, adjusting for age, sex, body mass index, and lung function. Conclusions: These findings offer a valuable blueprint on why and how the use of biomarkers as diagnostic tools can prove beneficial in guiding treatment management in respiratory diseases. MDPI 2022-05-24 /pmc/articles/PMC9224718/ /pubmed/35743805 http://dx.doi.org/10.3390/life12060775 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Nikolaou, Vasilis Massaro, Sebastiano Fakhimi, Masoud Garn, Wolfgang Using Machine Learning to Detect Theranostic Biomarkers Predicting Respiratory Treatment Response |
title | Using Machine Learning to Detect Theranostic Biomarkers Predicting Respiratory Treatment Response |
title_full | Using Machine Learning to Detect Theranostic Biomarkers Predicting Respiratory Treatment Response |
title_fullStr | Using Machine Learning to Detect Theranostic Biomarkers Predicting Respiratory Treatment Response |
title_full_unstemmed | Using Machine Learning to Detect Theranostic Biomarkers Predicting Respiratory Treatment Response |
title_short | Using Machine Learning to Detect Theranostic Biomarkers Predicting Respiratory Treatment Response |
title_sort | using machine learning to detect theranostic biomarkers predicting respiratory treatment response |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224718/ https://www.ncbi.nlm.nih.gov/pubmed/35743805 http://dx.doi.org/10.3390/life12060775 |
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