Significance of Autoantibodies to Ki/SL as Biomarkers for Systemic Lupus Erythematosus and Sicca Syndrome

Anti-Ki/SL antibodies were first described in 1981 and have been associated with systemic lupus erythematosus (SLE) and Sicca syndrome. Despite the long history, very little is known about this autoantibody system, and significant confusion persists. Anti-Ki/SL antibodies target a 32 kDa protein (al...

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Autores principales: Mahler, Michael, Bentow, Chelsea, Aure, Mary-Ann, Fritzler, Marvin J., Satoh, Minoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224748/
https://www.ncbi.nlm.nih.gov/pubmed/35743599
http://dx.doi.org/10.3390/jcm11123529
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author Mahler, Michael
Bentow, Chelsea
Aure, Mary-Ann
Fritzler, Marvin J.
Satoh, Minoru
author_facet Mahler, Michael
Bentow, Chelsea
Aure, Mary-Ann
Fritzler, Marvin J.
Satoh, Minoru
author_sort Mahler, Michael
collection PubMed
description Anti-Ki/SL antibodies were first described in 1981 and have been associated with systemic lupus erythematosus (SLE) and Sicca syndrome. Despite the long history, very little is known about this autoantibody system, and significant confusion persists. Anti-Ki/SL antibodies target a 32 kDa protein (also known as PSME3, HEL-S-283, PA28ƴ, REGƴ, proteasome activator subunit 3), which is part of the proteasome complex. Depending on the assay used and the cohort studied, the antibodies have been reported in approximately 20% of SLE patients with high disease specificity as compared to non-connective tissue disease controls. The aim of this review is to summarize the history and key publications, and to explore future direction of anti-Ki/SL antibodies.
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spelling pubmed-92247482022-06-24 Significance of Autoantibodies to Ki/SL as Biomarkers for Systemic Lupus Erythematosus and Sicca Syndrome Mahler, Michael Bentow, Chelsea Aure, Mary-Ann Fritzler, Marvin J. Satoh, Minoru J Clin Med Review Anti-Ki/SL antibodies were first described in 1981 and have been associated with systemic lupus erythematosus (SLE) and Sicca syndrome. Despite the long history, very little is known about this autoantibody system, and significant confusion persists. Anti-Ki/SL antibodies target a 32 kDa protein (also known as PSME3, HEL-S-283, PA28ƴ, REGƴ, proteasome activator subunit 3), which is part of the proteasome complex. Depending on the assay used and the cohort studied, the antibodies have been reported in approximately 20% of SLE patients with high disease specificity as compared to non-connective tissue disease controls. The aim of this review is to summarize the history and key publications, and to explore future direction of anti-Ki/SL antibodies. MDPI 2022-06-20 /pmc/articles/PMC9224748/ /pubmed/35743599 http://dx.doi.org/10.3390/jcm11123529 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mahler, Michael
Bentow, Chelsea
Aure, Mary-Ann
Fritzler, Marvin J.
Satoh, Minoru
Significance of Autoantibodies to Ki/SL as Biomarkers for Systemic Lupus Erythematosus and Sicca Syndrome
title Significance of Autoantibodies to Ki/SL as Biomarkers for Systemic Lupus Erythematosus and Sicca Syndrome
title_full Significance of Autoantibodies to Ki/SL as Biomarkers for Systemic Lupus Erythematosus and Sicca Syndrome
title_fullStr Significance of Autoantibodies to Ki/SL as Biomarkers for Systemic Lupus Erythematosus and Sicca Syndrome
title_full_unstemmed Significance of Autoantibodies to Ki/SL as Biomarkers for Systemic Lupus Erythematosus and Sicca Syndrome
title_short Significance of Autoantibodies to Ki/SL as Biomarkers for Systemic Lupus Erythematosus and Sicca Syndrome
title_sort significance of autoantibodies to ki/sl as biomarkers for systemic lupus erythematosus and sicca syndrome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224748/
https://www.ncbi.nlm.nih.gov/pubmed/35743599
http://dx.doi.org/10.3390/jcm11123529
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