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Regulatory Roles of Histone Modifications in Filamentous Fungal Pathogens

Filamentous fungal pathogens have evolved diverse strategies to infect a variety of hosts including plants and insects. The dynamic infection process requires rapid and fine-tuning regulation of fungal gene expression programs in response to the changing host environment and defenses. Therefore, tra...

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Detalles Bibliográficos
Autores principales: Lai, Yiling, Wang, Lili, Zheng, Weilu, Wang, Sibao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224773/
https://www.ncbi.nlm.nih.gov/pubmed/35736048
http://dx.doi.org/10.3390/jof8060565
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author Lai, Yiling
Wang, Lili
Zheng, Weilu
Wang, Sibao
author_facet Lai, Yiling
Wang, Lili
Zheng, Weilu
Wang, Sibao
author_sort Lai, Yiling
collection PubMed
description Filamentous fungal pathogens have evolved diverse strategies to infect a variety of hosts including plants and insects. The dynamic infection process requires rapid and fine-tuning regulation of fungal gene expression programs in response to the changing host environment and defenses. Therefore, transcriptional reprogramming of fungal pathogens is critical for fungal development and pathogenicity. Histone post-translational modification, one of the main mechanisms of epigenetic regulation, has been shown to play an important role in the regulation of gene expressions, and is involved in, e.g., fungal development, infection-related morphogenesis, environmental stress responses, biosynthesis of secondary metabolites, and pathogenicity. This review highlights recent findings and insights into regulatory mechanisms of histone methylation and acetylation in fungal development and pathogenicity, as well as their roles in modulating pathogenic fungi–host interactions.
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spelling pubmed-92247732022-06-24 Regulatory Roles of Histone Modifications in Filamentous Fungal Pathogens Lai, Yiling Wang, Lili Zheng, Weilu Wang, Sibao J Fungi (Basel) Review Filamentous fungal pathogens have evolved diverse strategies to infect a variety of hosts including plants and insects. The dynamic infection process requires rapid and fine-tuning regulation of fungal gene expression programs in response to the changing host environment and defenses. Therefore, transcriptional reprogramming of fungal pathogens is critical for fungal development and pathogenicity. Histone post-translational modification, one of the main mechanisms of epigenetic regulation, has been shown to play an important role in the regulation of gene expressions, and is involved in, e.g., fungal development, infection-related morphogenesis, environmental stress responses, biosynthesis of secondary metabolites, and pathogenicity. This review highlights recent findings and insights into regulatory mechanisms of histone methylation and acetylation in fungal development and pathogenicity, as well as their roles in modulating pathogenic fungi–host interactions. MDPI 2022-05-25 /pmc/articles/PMC9224773/ /pubmed/35736048 http://dx.doi.org/10.3390/jof8060565 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lai, Yiling
Wang, Lili
Zheng, Weilu
Wang, Sibao
Regulatory Roles of Histone Modifications in Filamentous Fungal Pathogens
title Regulatory Roles of Histone Modifications in Filamentous Fungal Pathogens
title_full Regulatory Roles of Histone Modifications in Filamentous Fungal Pathogens
title_fullStr Regulatory Roles of Histone Modifications in Filamentous Fungal Pathogens
title_full_unstemmed Regulatory Roles of Histone Modifications in Filamentous Fungal Pathogens
title_short Regulatory Roles of Histone Modifications in Filamentous Fungal Pathogens
title_sort regulatory roles of histone modifications in filamentous fungal pathogens
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224773/
https://www.ncbi.nlm.nih.gov/pubmed/35736048
http://dx.doi.org/10.3390/jof8060565
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