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Long-Term Pregnancy Outcomes of Patients with Diffuse Adenomyosis after Double-Flap Adenomyomectomy
Although many studies show that patients with diffuse adenomyosis who underwent fertility-sparing surgery can have a successful pregnancy, their pregnancy outcomes are still controversial. The objective of this study was to determine long-term pregnancy outcomes and possible influencing factors afte...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224895/ https://www.ncbi.nlm.nih.gov/pubmed/35743559 http://dx.doi.org/10.3390/jcm11123489 |
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author | Zhou, Yong Shen, Li Wang, Yuan Yang, Mengjia Chen, Zhengyun Zhang, Xinmei |
author_facet | Zhou, Yong Shen, Li Wang, Yuan Yang, Mengjia Chen, Zhengyun Zhang, Xinmei |
author_sort | Zhou, Yong |
collection | PubMed |
description | Although many studies show that patients with diffuse adenomyosis who underwent fertility-sparing surgery can have a successful pregnancy, their pregnancy outcomes are still controversial. The objective of this study was to determine long-term pregnancy outcomes and possible influencing factors after double-flap adenomyomectomy for patients with diffuse adenomyosis. A total of 137 patients with diffuse adenomyosis who underwent double-flap adenomyomectomy between January 2011 and December 2019 were studied, and correlations between pregnancy outcomes and clinical data, including age and junctional zone measured by magnetic resonance imaging (JZ(max-A)), were analyzed. The results show that 56 patients (40.9%, 56/137) had 62 pregnancies, including 35 natural pregnancies and 27 assisted reproduction pregnancies, after operation. A univariate regression analysis showed that the pregnancy outcomes were related to age at surgery, visual analog scale (VAS) score of preoperative dysmenorrhea, parity experience, length of infertility, and postoperative JZ(max-A). A multivariate regression analysis showed that age at surgery, VAS score of preoperative dysmenorrhea, and postoperative JZ(max-A) were the independent indicators correlated with pregnancy outcomes. A receiver operating characteristic curve analysis showed that postoperative JZ(max-A) was the most valuable indicator for predicting pregnancy outcomes. Cumulative pregnancy rates during the first 3 years were 70.1% and 20.9% in the postoperative JZ(max-A) ≤ 8.5 mm and the postoperative JZ(max-A) > 8.5 mm groups, respectively. In conclusion, double-flap adenomyomectomy could improve fertility for diffuse adenomyosis, and postoperative JZ(max-A) might be a promising indicator for predicting pregnancy outcomes. |
format | Online Article Text |
id | pubmed-9224895 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92248952022-06-24 Long-Term Pregnancy Outcomes of Patients with Diffuse Adenomyosis after Double-Flap Adenomyomectomy Zhou, Yong Shen, Li Wang, Yuan Yang, Mengjia Chen, Zhengyun Zhang, Xinmei J Clin Med Article Although many studies show that patients with diffuse adenomyosis who underwent fertility-sparing surgery can have a successful pregnancy, their pregnancy outcomes are still controversial. The objective of this study was to determine long-term pregnancy outcomes and possible influencing factors after double-flap adenomyomectomy for patients with diffuse adenomyosis. A total of 137 patients with diffuse adenomyosis who underwent double-flap adenomyomectomy between January 2011 and December 2019 were studied, and correlations between pregnancy outcomes and clinical data, including age and junctional zone measured by magnetic resonance imaging (JZ(max-A)), were analyzed. The results show that 56 patients (40.9%, 56/137) had 62 pregnancies, including 35 natural pregnancies and 27 assisted reproduction pregnancies, after operation. A univariate regression analysis showed that the pregnancy outcomes were related to age at surgery, visual analog scale (VAS) score of preoperative dysmenorrhea, parity experience, length of infertility, and postoperative JZ(max-A). A multivariate regression analysis showed that age at surgery, VAS score of preoperative dysmenorrhea, and postoperative JZ(max-A) were the independent indicators correlated with pregnancy outcomes. A receiver operating characteristic curve analysis showed that postoperative JZ(max-A) was the most valuable indicator for predicting pregnancy outcomes. Cumulative pregnancy rates during the first 3 years were 70.1% and 20.9% in the postoperative JZ(max-A) ≤ 8.5 mm and the postoperative JZ(max-A) > 8.5 mm groups, respectively. In conclusion, double-flap adenomyomectomy could improve fertility for diffuse adenomyosis, and postoperative JZ(max-A) might be a promising indicator for predicting pregnancy outcomes. MDPI 2022-06-17 /pmc/articles/PMC9224895/ /pubmed/35743559 http://dx.doi.org/10.3390/jcm11123489 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhou, Yong Shen, Li Wang, Yuan Yang, Mengjia Chen, Zhengyun Zhang, Xinmei Long-Term Pregnancy Outcomes of Patients with Diffuse Adenomyosis after Double-Flap Adenomyomectomy |
title | Long-Term Pregnancy Outcomes of Patients with Diffuse Adenomyosis after Double-Flap Adenomyomectomy |
title_full | Long-Term Pregnancy Outcomes of Patients with Diffuse Adenomyosis after Double-Flap Adenomyomectomy |
title_fullStr | Long-Term Pregnancy Outcomes of Patients with Diffuse Adenomyosis after Double-Flap Adenomyomectomy |
title_full_unstemmed | Long-Term Pregnancy Outcomes of Patients with Diffuse Adenomyosis after Double-Flap Adenomyomectomy |
title_short | Long-Term Pregnancy Outcomes of Patients with Diffuse Adenomyosis after Double-Flap Adenomyomectomy |
title_sort | long-term pregnancy outcomes of patients with diffuse adenomyosis after double-flap adenomyomectomy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224895/ https://www.ncbi.nlm.nih.gov/pubmed/35743559 http://dx.doi.org/10.3390/jcm11123489 |
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