Cargando…

Potential Cancer Risk in Patients with Rheumatoid Arthritis: A Longitudinal Korean Population-Based Analysis

The potential link between rheumatoid arthritis (RA) and cancer incidence needs to be validated due to inconsistent results between Asian and Western countries. We explored the long-term association of RA with the overall and organ-specific cancer incidence using nationwide population data. This lon...

Descripción completa

Detalles Bibliográficos
Autores principales: Choi, Hyo Geun, Kang, Ho Suk, Lim, Hyun, Kim, Joo-Hee, Kim, Ji Hee, Cho, Seong-Jin, Nam, Eun Sook, Min, Kyueng-Whan, Park, Ha Young, Kim, Nan Young, Kwon, Mi Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224951/
https://www.ncbi.nlm.nih.gov/pubmed/35743750
http://dx.doi.org/10.3390/jpm12060965
_version_ 1784733497307430912
author Choi, Hyo Geun
Kang, Ho Suk
Lim, Hyun
Kim, Joo-Hee
Kim, Ji Hee
Cho, Seong-Jin
Nam, Eun Sook
Min, Kyueng-Whan
Park, Ha Young
Kim, Nan Young
Kwon, Mi Jung
author_facet Choi, Hyo Geun
Kang, Ho Suk
Lim, Hyun
Kim, Joo-Hee
Kim, Ji Hee
Cho, Seong-Jin
Nam, Eun Sook
Min, Kyueng-Whan
Park, Ha Young
Kim, Nan Young
Kwon, Mi Jung
author_sort Choi, Hyo Geun
collection PubMed
description The potential link between rheumatoid arthritis (RA) and cancer incidence needs to be validated due to inconsistent results between Asian and Western countries. We explored the long-term association of RA with the overall and organ-specific cancer incidence using nationwide population data. This longitudinal follow-up study (2002–2015) included 3070 patients with RA and 12,280 controls (1:4 propensity score-matched for sex, age, residence, and income) from the Korean National Health Insurance Service-Health Screening Cohort database. A Cox proportional hazard model estimated the hazard ratio for malignancy following adjusting for covariates. Despite the similar overall cancer incidence between RA and control groups, differences in the incidence of organ-specific cancers were noted: the RA group had a 1.63-fold greater likelihood for lung cancer (95% confidence interval 1.11–2.40). In the sex-stratified subgroup analyses, the male RA patients exhibited higher odds of lung and thyroid cancer but a lower probability for colorectal cancer; no such associations were detected in either female patients with RA or age subgroups. In summary, the higher likelihood for lung cancer in Korean RA patients, especially thyroid and lung cancer in male RA patients, seems to be characteristic, which needs to be carefully monitored.
format Online
Article
Text
id pubmed-9224951
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-92249512022-06-24 Potential Cancer Risk in Patients with Rheumatoid Arthritis: A Longitudinal Korean Population-Based Analysis Choi, Hyo Geun Kang, Ho Suk Lim, Hyun Kim, Joo-Hee Kim, Ji Hee Cho, Seong-Jin Nam, Eun Sook Min, Kyueng-Whan Park, Ha Young Kim, Nan Young Kwon, Mi Jung J Pers Med Article The potential link between rheumatoid arthritis (RA) and cancer incidence needs to be validated due to inconsistent results between Asian and Western countries. We explored the long-term association of RA with the overall and organ-specific cancer incidence using nationwide population data. This longitudinal follow-up study (2002–2015) included 3070 patients with RA and 12,280 controls (1:4 propensity score-matched for sex, age, residence, and income) from the Korean National Health Insurance Service-Health Screening Cohort database. A Cox proportional hazard model estimated the hazard ratio for malignancy following adjusting for covariates. Despite the similar overall cancer incidence between RA and control groups, differences in the incidence of organ-specific cancers were noted: the RA group had a 1.63-fold greater likelihood for lung cancer (95% confidence interval 1.11–2.40). In the sex-stratified subgroup analyses, the male RA patients exhibited higher odds of lung and thyroid cancer but a lower probability for colorectal cancer; no such associations were detected in either female patients with RA or age subgroups. In summary, the higher likelihood for lung cancer in Korean RA patients, especially thyroid and lung cancer in male RA patients, seems to be characteristic, which needs to be carefully monitored. MDPI 2022-06-13 /pmc/articles/PMC9224951/ /pubmed/35743750 http://dx.doi.org/10.3390/jpm12060965 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Choi, Hyo Geun
Kang, Ho Suk
Lim, Hyun
Kim, Joo-Hee
Kim, Ji Hee
Cho, Seong-Jin
Nam, Eun Sook
Min, Kyueng-Whan
Park, Ha Young
Kim, Nan Young
Kwon, Mi Jung
Potential Cancer Risk in Patients with Rheumatoid Arthritis: A Longitudinal Korean Population-Based Analysis
title Potential Cancer Risk in Patients with Rheumatoid Arthritis: A Longitudinal Korean Population-Based Analysis
title_full Potential Cancer Risk in Patients with Rheumatoid Arthritis: A Longitudinal Korean Population-Based Analysis
title_fullStr Potential Cancer Risk in Patients with Rheumatoid Arthritis: A Longitudinal Korean Population-Based Analysis
title_full_unstemmed Potential Cancer Risk in Patients with Rheumatoid Arthritis: A Longitudinal Korean Population-Based Analysis
title_short Potential Cancer Risk in Patients with Rheumatoid Arthritis: A Longitudinal Korean Population-Based Analysis
title_sort potential cancer risk in patients with rheumatoid arthritis: a longitudinal korean population-based analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224951/
https://www.ncbi.nlm.nih.gov/pubmed/35743750
http://dx.doi.org/10.3390/jpm12060965
work_keys_str_mv AT choihyogeun potentialcancerriskinpatientswithrheumatoidarthritisalongitudinalkoreanpopulationbasedanalysis
AT kanghosuk potentialcancerriskinpatientswithrheumatoidarthritisalongitudinalkoreanpopulationbasedanalysis
AT limhyun potentialcancerriskinpatientswithrheumatoidarthritisalongitudinalkoreanpopulationbasedanalysis
AT kimjoohee potentialcancerriskinpatientswithrheumatoidarthritisalongitudinalkoreanpopulationbasedanalysis
AT kimjihee potentialcancerriskinpatientswithrheumatoidarthritisalongitudinalkoreanpopulationbasedanalysis
AT choseongjin potentialcancerriskinpatientswithrheumatoidarthritisalongitudinalkoreanpopulationbasedanalysis
AT nameunsook potentialcancerriskinpatientswithrheumatoidarthritisalongitudinalkoreanpopulationbasedanalysis
AT minkyuengwhan potentialcancerriskinpatientswithrheumatoidarthritisalongitudinalkoreanpopulationbasedanalysis
AT parkhayoung potentialcancerriskinpatientswithrheumatoidarthritisalongitudinalkoreanpopulationbasedanalysis
AT kimnanyoung potentialcancerriskinpatientswithrheumatoidarthritisalongitudinalkoreanpopulationbasedanalysis
AT kwonmijung potentialcancerriskinpatientswithrheumatoidarthritisalongitudinalkoreanpopulationbasedanalysis