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Potential Cancer Risk in Patients with Rheumatoid Arthritis: A Longitudinal Korean Population-Based Analysis
The potential link between rheumatoid arthritis (RA) and cancer incidence needs to be validated due to inconsistent results between Asian and Western countries. We explored the long-term association of RA with the overall and organ-specific cancer incidence using nationwide population data. This lon...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224951/ https://www.ncbi.nlm.nih.gov/pubmed/35743750 http://dx.doi.org/10.3390/jpm12060965 |
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author | Choi, Hyo Geun Kang, Ho Suk Lim, Hyun Kim, Joo-Hee Kim, Ji Hee Cho, Seong-Jin Nam, Eun Sook Min, Kyueng-Whan Park, Ha Young Kim, Nan Young Kwon, Mi Jung |
author_facet | Choi, Hyo Geun Kang, Ho Suk Lim, Hyun Kim, Joo-Hee Kim, Ji Hee Cho, Seong-Jin Nam, Eun Sook Min, Kyueng-Whan Park, Ha Young Kim, Nan Young Kwon, Mi Jung |
author_sort | Choi, Hyo Geun |
collection | PubMed |
description | The potential link between rheumatoid arthritis (RA) and cancer incidence needs to be validated due to inconsistent results between Asian and Western countries. We explored the long-term association of RA with the overall and organ-specific cancer incidence using nationwide population data. This longitudinal follow-up study (2002–2015) included 3070 patients with RA and 12,280 controls (1:4 propensity score-matched for sex, age, residence, and income) from the Korean National Health Insurance Service-Health Screening Cohort database. A Cox proportional hazard model estimated the hazard ratio for malignancy following adjusting for covariates. Despite the similar overall cancer incidence between RA and control groups, differences in the incidence of organ-specific cancers were noted: the RA group had a 1.63-fold greater likelihood for lung cancer (95% confidence interval 1.11–2.40). In the sex-stratified subgroup analyses, the male RA patients exhibited higher odds of lung and thyroid cancer but a lower probability for colorectal cancer; no such associations were detected in either female patients with RA or age subgroups. In summary, the higher likelihood for lung cancer in Korean RA patients, especially thyroid and lung cancer in male RA patients, seems to be characteristic, which needs to be carefully monitored. |
format | Online Article Text |
id | pubmed-9224951 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92249512022-06-24 Potential Cancer Risk in Patients with Rheumatoid Arthritis: A Longitudinal Korean Population-Based Analysis Choi, Hyo Geun Kang, Ho Suk Lim, Hyun Kim, Joo-Hee Kim, Ji Hee Cho, Seong-Jin Nam, Eun Sook Min, Kyueng-Whan Park, Ha Young Kim, Nan Young Kwon, Mi Jung J Pers Med Article The potential link between rheumatoid arthritis (RA) and cancer incidence needs to be validated due to inconsistent results between Asian and Western countries. We explored the long-term association of RA with the overall and organ-specific cancer incidence using nationwide population data. This longitudinal follow-up study (2002–2015) included 3070 patients with RA and 12,280 controls (1:4 propensity score-matched for sex, age, residence, and income) from the Korean National Health Insurance Service-Health Screening Cohort database. A Cox proportional hazard model estimated the hazard ratio for malignancy following adjusting for covariates. Despite the similar overall cancer incidence between RA and control groups, differences in the incidence of organ-specific cancers were noted: the RA group had a 1.63-fold greater likelihood for lung cancer (95% confidence interval 1.11–2.40). In the sex-stratified subgroup analyses, the male RA patients exhibited higher odds of lung and thyroid cancer but a lower probability for colorectal cancer; no such associations were detected in either female patients with RA or age subgroups. In summary, the higher likelihood for lung cancer in Korean RA patients, especially thyroid and lung cancer in male RA patients, seems to be characteristic, which needs to be carefully monitored. MDPI 2022-06-13 /pmc/articles/PMC9224951/ /pubmed/35743750 http://dx.doi.org/10.3390/jpm12060965 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Choi, Hyo Geun Kang, Ho Suk Lim, Hyun Kim, Joo-Hee Kim, Ji Hee Cho, Seong-Jin Nam, Eun Sook Min, Kyueng-Whan Park, Ha Young Kim, Nan Young Kwon, Mi Jung Potential Cancer Risk in Patients with Rheumatoid Arthritis: A Longitudinal Korean Population-Based Analysis |
title | Potential Cancer Risk in Patients with Rheumatoid Arthritis: A Longitudinal Korean Population-Based Analysis |
title_full | Potential Cancer Risk in Patients with Rheumatoid Arthritis: A Longitudinal Korean Population-Based Analysis |
title_fullStr | Potential Cancer Risk in Patients with Rheumatoid Arthritis: A Longitudinal Korean Population-Based Analysis |
title_full_unstemmed | Potential Cancer Risk in Patients with Rheumatoid Arthritis: A Longitudinal Korean Population-Based Analysis |
title_short | Potential Cancer Risk in Patients with Rheumatoid Arthritis: A Longitudinal Korean Population-Based Analysis |
title_sort | potential cancer risk in patients with rheumatoid arthritis: a longitudinal korean population-based analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224951/ https://www.ncbi.nlm.nih.gov/pubmed/35743750 http://dx.doi.org/10.3390/jpm12060965 |
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