DOG1-Positive Primary Mesenteric Leiomyosarcoma: Report of a Case and Review of the Literature

The mesentery constitutes a common location for the metastatic spread of malignant gastrointestinal tumors. Primary mesenteric tumors, on the other hand, are very rare; lymphomas are the most common, followed by benign and malignant mesenchymal tumors. We present a case of a 43-year-old patient oper...

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Autores principales: Koufopoulos, Nektarios, Damaskou, Vasileia, Siozopoulou, Vasiliki, Kokoropoulos, Panagiotis, Gouloumis, Alina-Roxani, Arkadopoulos, Nikolaos, Panayiotides, Ioannis G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224980/
https://www.ncbi.nlm.nih.gov/pubmed/35755504
http://dx.doi.org/10.7759/cureus.25263
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author Koufopoulos, Nektarios
Damaskou, Vasileia
Siozopoulou, Vasiliki
Kokoropoulos, Panagiotis
Gouloumis, Alina-Roxani
Arkadopoulos, Nikolaos
Panayiotides, Ioannis G
author_facet Koufopoulos, Nektarios
Damaskou, Vasileia
Siozopoulou, Vasiliki
Kokoropoulos, Panagiotis
Gouloumis, Alina-Roxani
Arkadopoulos, Nikolaos
Panayiotides, Ioannis G
author_sort Koufopoulos, Nektarios
collection PubMed
description The mesentery constitutes a common location for the metastatic spread of malignant gastrointestinal tumors. Primary mesenteric tumors, on the other hand, are very rare; lymphomas are the most common, followed by benign and malignant mesenchymal tumors. We present a case of a 43-year-old patient operated on for a primary mesenteric leiomyosarcoma with a positive immunostain for DOG1, despite having no KIT or PDGFRa mutations on molecular analysis. Moreover, we review the pertinent literature. 
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spelling pubmed-92249802022-06-24 DOG1-Positive Primary Mesenteric Leiomyosarcoma: Report of a Case and Review of the Literature Koufopoulos, Nektarios Damaskou, Vasileia Siozopoulou, Vasiliki Kokoropoulos, Panagiotis Gouloumis, Alina-Roxani Arkadopoulos, Nikolaos Panayiotides, Ioannis G Cureus Pathology The mesentery constitutes a common location for the metastatic spread of malignant gastrointestinal tumors. Primary mesenteric tumors, on the other hand, are very rare; lymphomas are the most common, followed by benign and malignant mesenchymal tumors. We present a case of a 43-year-old patient operated on for a primary mesenteric leiomyosarcoma with a positive immunostain for DOG1, despite having no KIT or PDGFRa mutations on molecular analysis. Moreover, we review the pertinent literature.  Cureus 2022-05-23 /pmc/articles/PMC9224980/ /pubmed/35755504 http://dx.doi.org/10.7759/cureus.25263 Text en Copyright © 2022, Koufopoulos et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pathology
Koufopoulos, Nektarios
Damaskou, Vasileia
Siozopoulou, Vasiliki
Kokoropoulos, Panagiotis
Gouloumis, Alina-Roxani
Arkadopoulos, Nikolaos
Panayiotides, Ioannis G
DOG1-Positive Primary Mesenteric Leiomyosarcoma: Report of a Case and Review of the Literature
title DOG1-Positive Primary Mesenteric Leiomyosarcoma: Report of a Case and Review of the Literature
title_full DOG1-Positive Primary Mesenteric Leiomyosarcoma: Report of a Case and Review of the Literature
title_fullStr DOG1-Positive Primary Mesenteric Leiomyosarcoma: Report of a Case and Review of the Literature
title_full_unstemmed DOG1-Positive Primary Mesenteric Leiomyosarcoma: Report of a Case and Review of the Literature
title_short DOG1-Positive Primary Mesenteric Leiomyosarcoma: Report of a Case and Review of the Literature
title_sort dog1-positive primary mesenteric leiomyosarcoma: report of a case and review of the literature
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224980/
https://www.ncbi.nlm.nih.gov/pubmed/35755504
http://dx.doi.org/10.7759/cureus.25263
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