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Role of ABCA1 in Cardiovascular Disease
Cholesterol homeostasis plays a significant role in cardiovascular disease. Previous studies have indicated that ATP-binding cassette transporter A1 (ABCA1) is one of the most important proteins that maintains cholesterol homeostasis. ABCA1 mediates nascent high-density lipoprotein biogenesis. Upon...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225161/ https://www.ncbi.nlm.nih.gov/pubmed/35743794 http://dx.doi.org/10.3390/jpm12061010 |
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author | Wang, Jing Xiao, Qianqian Wang, Luyun Wang, Yan Wang, Daowen Ding, Hu |
author_facet | Wang, Jing Xiao, Qianqian Wang, Luyun Wang, Yan Wang, Daowen Ding, Hu |
author_sort | Wang, Jing |
collection | PubMed |
description | Cholesterol homeostasis plays a significant role in cardiovascular disease. Previous studies have indicated that ATP-binding cassette transporter A1 (ABCA1) is one of the most important proteins that maintains cholesterol homeostasis. ABCA1 mediates nascent high-density lipoprotein biogenesis. Upon binding with apolipoprotein A-I, ABCA1 facilitates the efflux of excess intracellular cholesterol and phospholipids and controls the rate-limiting step of reverse cholesterol transport. In addition, ABCA1 interacts with the apolipoprotein receptor and suppresses inflammation through a series of signaling pathways. Thus, ABCA1 may prevent cardiovascular disease by inhibiting inflammation and maintaining lipid homeostasis. Several studies have indicated that post-transcriptional modifications play a critical role in the regulation of ABCA1 transportation and plasma membrane localization, which affects its biological function. Meanwhile, carriers of the loss-of-function ABCA1 gene are often accompanied by decreased expression of ABCA1 and an increased risk of cardiovascular diseases. We summarized the ABCA1 transcription regulation mechanism, mutations, post-translational modifications, and their roles in the development of dyslipidemia, atherosclerosis, ischemia/reperfusion, myocardial infarction, and coronary heart disease. |
format | Online Article Text |
id | pubmed-9225161 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92251612022-06-24 Role of ABCA1 in Cardiovascular Disease Wang, Jing Xiao, Qianqian Wang, Luyun Wang, Yan Wang, Daowen Ding, Hu J Pers Med Review Cholesterol homeostasis plays a significant role in cardiovascular disease. Previous studies have indicated that ATP-binding cassette transporter A1 (ABCA1) is one of the most important proteins that maintains cholesterol homeostasis. ABCA1 mediates nascent high-density lipoprotein biogenesis. Upon binding with apolipoprotein A-I, ABCA1 facilitates the efflux of excess intracellular cholesterol and phospholipids and controls the rate-limiting step of reverse cholesterol transport. In addition, ABCA1 interacts with the apolipoprotein receptor and suppresses inflammation through a series of signaling pathways. Thus, ABCA1 may prevent cardiovascular disease by inhibiting inflammation and maintaining lipid homeostasis. Several studies have indicated that post-transcriptional modifications play a critical role in the regulation of ABCA1 transportation and plasma membrane localization, which affects its biological function. Meanwhile, carriers of the loss-of-function ABCA1 gene are often accompanied by decreased expression of ABCA1 and an increased risk of cardiovascular diseases. We summarized the ABCA1 transcription regulation mechanism, mutations, post-translational modifications, and their roles in the development of dyslipidemia, atherosclerosis, ischemia/reperfusion, myocardial infarction, and coronary heart disease. MDPI 2022-06-20 /pmc/articles/PMC9225161/ /pubmed/35743794 http://dx.doi.org/10.3390/jpm12061010 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wang, Jing Xiao, Qianqian Wang, Luyun Wang, Yan Wang, Daowen Ding, Hu Role of ABCA1 in Cardiovascular Disease |
title | Role of ABCA1 in Cardiovascular Disease |
title_full | Role of ABCA1 in Cardiovascular Disease |
title_fullStr | Role of ABCA1 in Cardiovascular Disease |
title_full_unstemmed | Role of ABCA1 in Cardiovascular Disease |
title_short | Role of ABCA1 in Cardiovascular Disease |
title_sort | role of abca1 in cardiovascular disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225161/ https://www.ncbi.nlm.nih.gov/pubmed/35743794 http://dx.doi.org/10.3390/jpm12061010 |
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