Biomarkers Predictive of Metabolic Syndrome and Cardiovascular Disease in Childhood Cancer Survivors

The improvement in childhood cancer treatments resulted in a marked improvement in the survival of pediatric cancer patients. However, as survival increased, it was also possible to observe the long-term side effects of cancer therapies. Among these, metabolic syndrome is one of the most frequent lo...

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Autores principales: Romano, Alberto, Del Vescovo, Ester, Rivetti, Serena, Triarico, Silvia, Attinà, Giorgio, Mastrangelo, Stefano, Maurizi, Palma, Ruggiero, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225298/
https://www.ncbi.nlm.nih.gov/pubmed/35743665
http://dx.doi.org/10.3390/jpm12060880
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author Romano, Alberto
Del Vescovo, Ester
Rivetti, Serena
Triarico, Silvia
Attinà, Giorgio
Mastrangelo, Stefano
Maurizi, Palma
Ruggiero, Antonio
author_facet Romano, Alberto
Del Vescovo, Ester
Rivetti, Serena
Triarico, Silvia
Attinà, Giorgio
Mastrangelo, Stefano
Maurizi, Palma
Ruggiero, Antonio
author_sort Romano, Alberto
collection PubMed
description The improvement in childhood cancer treatments resulted in a marked improvement in the survival of pediatric cancer patients. However, as survival increased, it was also possible to observe the long-term side effects of cancer therapies. Among these, metabolic syndrome is one of the most frequent long-term side effects, and causes high mortality and morbidity. Consequently, it is necessary to identify strategies that allow for early diagnosis. In this review, the pathogenetic mechanisms of metabolic syndrome and the potential new biomarkers that can facilitate its diagnosis in survivors of pediatric tumors are analyzed.
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spelling pubmed-92252982022-06-24 Biomarkers Predictive of Metabolic Syndrome and Cardiovascular Disease in Childhood Cancer Survivors Romano, Alberto Del Vescovo, Ester Rivetti, Serena Triarico, Silvia Attinà, Giorgio Mastrangelo, Stefano Maurizi, Palma Ruggiero, Antonio J Pers Med Review The improvement in childhood cancer treatments resulted in a marked improvement in the survival of pediatric cancer patients. However, as survival increased, it was also possible to observe the long-term side effects of cancer therapies. Among these, metabolic syndrome is one of the most frequent long-term side effects, and causes high mortality and morbidity. Consequently, it is necessary to identify strategies that allow for early diagnosis. In this review, the pathogenetic mechanisms of metabolic syndrome and the potential new biomarkers that can facilitate its diagnosis in survivors of pediatric tumors are analyzed. MDPI 2022-05-27 /pmc/articles/PMC9225298/ /pubmed/35743665 http://dx.doi.org/10.3390/jpm12060880 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Romano, Alberto
Del Vescovo, Ester
Rivetti, Serena
Triarico, Silvia
Attinà, Giorgio
Mastrangelo, Stefano
Maurizi, Palma
Ruggiero, Antonio
Biomarkers Predictive of Metabolic Syndrome and Cardiovascular Disease in Childhood Cancer Survivors
title Biomarkers Predictive of Metabolic Syndrome and Cardiovascular Disease in Childhood Cancer Survivors
title_full Biomarkers Predictive of Metabolic Syndrome and Cardiovascular Disease in Childhood Cancer Survivors
title_fullStr Biomarkers Predictive of Metabolic Syndrome and Cardiovascular Disease in Childhood Cancer Survivors
title_full_unstemmed Biomarkers Predictive of Metabolic Syndrome and Cardiovascular Disease in Childhood Cancer Survivors
title_short Biomarkers Predictive of Metabolic Syndrome and Cardiovascular Disease in Childhood Cancer Survivors
title_sort biomarkers predictive of metabolic syndrome and cardiovascular disease in childhood cancer survivors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225298/
https://www.ncbi.nlm.nih.gov/pubmed/35743665
http://dx.doi.org/10.3390/jpm12060880
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