YAP Inhibition by Verteporfin Causes Downregulation of Desmosomal Genes and Proteins Leading to the Disintegration of Intercellular Junctions

The Hippo-YAP pathway serves as a central signalling hub in epithelial tissue generation and homeostasis. Yes-associated protein (YAP) is an essential downstream transcription cofactor of this pathway, with its activity being negatively regulated by Hippo kinase-mediated phosphorylation, leading to...

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Detalles Bibliográficos
Autores principales: Huang, Yunying, Ahmad, Usama Sharif, Rehman, Ambreen, Uttagomol, Jutamas, Wan, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225343/
https://www.ncbi.nlm.nih.gov/pubmed/35743822
http://dx.doi.org/10.3390/life12060792

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225343/
https://www.ncbi.nlm.nih.gov/pubmed/35743822
http://dx.doi.org/10.3390/life12060792

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