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Hemostatic Biomarkers and Volumetry Help to Identify High-Risk Abdominal Aortic Aneurysms

Predicting the progression of small aneurysms is a main challenge in abdominal aortic aneurysm (AAA) management. The combination of circulating biomarkers and image techniques might provide an alternative for risk stratification. We evaluated the association of plasma TAT complexes (TAT) and D-dimer...

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Autores principales: Fernandez-Alonso, Sebastian, Martinez-Aguilar, Esther, Ravassa, Susana, Orbe, Josune, Paramo, Jose A., Fernandez-Alonso, Leopoldo, Roncal, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225361/
https://www.ncbi.nlm.nih.gov/pubmed/35743854
http://dx.doi.org/10.3390/life12060823
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author Fernandez-Alonso, Sebastian
Martinez-Aguilar, Esther
Ravassa, Susana
Orbe, Josune
Paramo, Jose A.
Fernandez-Alonso, Leopoldo
Roncal, Carmen
author_facet Fernandez-Alonso, Sebastian
Martinez-Aguilar, Esther
Ravassa, Susana
Orbe, Josune
Paramo, Jose A.
Fernandez-Alonso, Leopoldo
Roncal, Carmen
author_sort Fernandez-Alonso, Sebastian
collection PubMed
description Predicting the progression of small aneurysms is a main challenge in abdominal aortic aneurysm (AAA) management. The combination of circulating biomarkers and image techniques might provide an alternative for risk stratification. We evaluated the association of plasma TAT complexes (TAT) and D-dimer with AAA severity in 3 groups of patients: group 1, without AAA (n = 52), group 2, AAA 40–50 mm (n = 51) and group 3, AAA > 50 mm (n = 50). TAT (p < 0.001) and D-dimer (p < 0.001) were increased in patients with AAA (groups 2 and 3) vs. group 1. To assess the association between baseline TAT and D-dimer concentrations, and AAA growth, aortic diameter and volume (volumetry) were measured by computed tomography angiography (CTA) in group 2 at recruitment (baseline) and 1-year after inclusion. Baseline D-dimer and TAT levels were associated with AAA diameter and volume variations at 1-year independently of confounding factors (p ≤ 0.044). Additionally, surgery incidence, recorded during a 4-year follow-up in group 2, was associated with larger aneurysms, assessed by aortic diameter and volumetry (p ≤ 0.036), and with elevated TAT levels (sub-hazard ratio 1.3, p ≤ 0.029), while no association was found for D-dimer. The combination of hemostatic parameters and image techniques might provide valuable tools to evaluate AAA growth and worse evolution.
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spelling pubmed-92253612022-06-24 Hemostatic Biomarkers and Volumetry Help to Identify High-Risk Abdominal Aortic Aneurysms Fernandez-Alonso, Sebastian Martinez-Aguilar, Esther Ravassa, Susana Orbe, Josune Paramo, Jose A. Fernandez-Alonso, Leopoldo Roncal, Carmen Life (Basel) Article Predicting the progression of small aneurysms is a main challenge in abdominal aortic aneurysm (AAA) management. The combination of circulating biomarkers and image techniques might provide an alternative for risk stratification. We evaluated the association of plasma TAT complexes (TAT) and D-dimer with AAA severity in 3 groups of patients: group 1, without AAA (n = 52), group 2, AAA 40–50 mm (n = 51) and group 3, AAA > 50 mm (n = 50). TAT (p < 0.001) and D-dimer (p < 0.001) were increased in patients with AAA (groups 2 and 3) vs. group 1. To assess the association between baseline TAT and D-dimer concentrations, and AAA growth, aortic diameter and volume (volumetry) were measured by computed tomography angiography (CTA) in group 2 at recruitment (baseline) and 1-year after inclusion. Baseline D-dimer and TAT levels were associated with AAA diameter and volume variations at 1-year independently of confounding factors (p ≤ 0.044). Additionally, surgery incidence, recorded during a 4-year follow-up in group 2, was associated with larger aneurysms, assessed by aortic diameter and volumetry (p ≤ 0.036), and with elevated TAT levels (sub-hazard ratio 1.3, p ≤ 0.029), while no association was found for D-dimer. The combination of hemostatic parameters and image techniques might provide valuable tools to evaluate AAA growth and worse evolution. MDPI 2022-05-31 /pmc/articles/PMC9225361/ /pubmed/35743854 http://dx.doi.org/10.3390/life12060823 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fernandez-Alonso, Sebastian
Martinez-Aguilar, Esther
Ravassa, Susana
Orbe, Josune
Paramo, Jose A.
Fernandez-Alonso, Leopoldo
Roncal, Carmen
Hemostatic Biomarkers and Volumetry Help to Identify High-Risk Abdominal Aortic Aneurysms
title Hemostatic Biomarkers and Volumetry Help to Identify High-Risk Abdominal Aortic Aneurysms
title_full Hemostatic Biomarkers and Volumetry Help to Identify High-Risk Abdominal Aortic Aneurysms
title_fullStr Hemostatic Biomarkers and Volumetry Help to Identify High-Risk Abdominal Aortic Aneurysms
title_full_unstemmed Hemostatic Biomarkers and Volumetry Help to Identify High-Risk Abdominal Aortic Aneurysms
title_short Hemostatic Biomarkers and Volumetry Help to Identify High-Risk Abdominal Aortic Aneurysms
title_sort hemostatic biomarkers and volumetry help to identify high-risk abdominal aortic aneurysms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225361/
https://www.ncbi.nlm.nih.gov/pubmed/35743854
http://dx.doi.org/10.3390/life12060823
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