2-(3-Bromophenyl)-8-fluoroquinazoline-4-carboxylic Acid as a Novel and Selective Aurora A Kinase Inhibitory Lead with Apoptosis Properties: Design, Synthesis, In Vitro and In Silico Biological Evaluation

New quinazoline derivatives were designed based on the structural modification of the reported inhibitors to enhance their selectivity toward Aurora A. The synthesized compounds were tested over Aurora A, and a cytotoxicity assay was performed over NCI cell lines to select the best candidate for fur...

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Detalles Bibliográficos
Autores principales: Elsherbeny, Mohamed H., Ammar, Usama M., Abdellattif, Magda H., Abourehab, Mohammed A. S., Abdeen, Ahmed, Ibrahim, Samah F., Abdelrahaman, Doaa, Mady, Wessam, Roh, Eun Joo, Elkamhawy, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225547/
https://www.ncbi.nlm.nih.gov/pubmed/35743907
http://dx.doi.org/10.3390/life12060876

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