Cargando…
The Assessment of COVID-19 Pneumonia in Neonates: Observed by Lung Ultrasound Technique and Correlated with Biomarkers and Symptoms
Newborns infected with SARS-CoV2 infection develop different symptoms in comparison with adults, but one thing is clear: some of the most common manifestations include cough and other respiratory symptoms that need to be evaluated. In these cases, lung ultrasound is a useful imaging technique that c...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225555/ https://www.ncbi.nlm.nih.gov/pubmed/35743621 http://dx.doi.org/10.3390/jcm11123555 |
_version_ | 1784733641489776640 |
---|---|
author | Stoicescu, Emil Robert Manolescu, Diana Luminita Iacob, Roxana Cerbu, Simona Dima, Mirabela Iacob, Emil Radu Ciuca, Ioana Mihaiela Oancea, Cristian Iacob, Daniela |
author_facet | Stoicescu, Emil Robert Manolescu, Diana Luminita Iacob, Roxana Cerbu, Simona Dima, Mirabela Iacob, Emil Radu Ciuca, Ioana Mihaiela Oancea, Cristian Iacob, Daniela |
author_sort | Stoicescu, Emil Robert |
collection | PubMed |
description | Newborns infected with SARS-CoV2 infection develop different symptoms in comparison with adults, but one thing is clear: some of the most common manifestations include cough and other respiratory symptoms that need to be evaluated. In these cases, lung ultrasound is a useful imaging technique that can evaluate the newborns’ lung damage caused by COVID-19 pneumonia and can be used for the surveillance of the patients as well, being non-irradiating and easy to use. Nineteen neonates who were confirmed as having SARS-CoV2 infection were investigated using this imaging tool, and the results were compared and correlated with their symptoms and biomarkers. The mean of LUSS was 12.21 ± 3.56 (S.D), while the 95% CI for the arithmetic mean was 10.49–13.93. The difference of an independent t-test between the LUSS for the patient who presented cough and the LUSS for the patient without cough was −4.48 with an associated p-value of p = 0.02. The Pearson’s correlation coefficient r = 0.89 (p = 0.03, 95% CI 0.0642 to 0.993) between the LUSS and IL-6 level showed a positive strong correlation. This reliable correlation between lung ultrasound score and inflammatory markers suggests that LUS could be used for monitoring inflammatory lung diseases in the future. |
format | Online Article Text |
id | pubmed-9225555 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92255552022-06-24 The Assessment of COVID-19 Pneumonia in Neonates: Observed by Lung Ultrasound Technique and Correlated with Biomarkers and Symptoms Stoicescu, Emil Robert Manolescu, Diana Luminita Iacob, Roxana Cerbu, Simona Dima, Mirabela Iacob, Emil Radu Ciuca, Ioana Mihaiela Oancea, Cristian Iacob, Daniela J Clin Med Article Newborns infected with SARS-CoV2 infection develop different symptoms in comparison with adults, but one thing is clear: some of the most common manifestations include cough and other respiratory symptoms that need to be evaluated. In these cases, lung ultrasound is a useful imaging technique that can evaluate the newborns’ lung damage caused by COVID-19 pneumonia and can be used for the surveillance of the patients as well, being non-irradiating and easy to use. Nineteen neonates who were confirmed as having SARS-CoV2 infection were investigated using this imaging tool, and the results were compared and correlated with their symptoms and biomarkers. The mean of LUSS was 12.21 ± 3.56 (S.D), while the 95% CI for the arithmetic mean was 10.49–13.93. The difference of an independent t-test between the LUSS for the patient who presented cough and the LUSS for the patient without cough was −4.48 with an associated p-value of p = 0.02. The Pearson’s correlation coefficient r = 0.89 (p = 0.03, 95% CI 0.0642 to 0.993) between the LUSS and IL-6 level showed a positive strong correlation. This reliable correlation between lung ultrasound score and inflammatory markers suggests that LUS could be used for monitoring inflammatory lung diseases in the future. MDPI 2022-06-20 /pmc/articles/PMC9225555/ /pubmed/35743621 http://dx.doi.org/10.3390/jcm11123555 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Stoicescu, Emil Robert Manolescu, Diana Luminita Iacob, Roxana Cerbu, Simona Dima, Mirabela Iacob, Emil Radu Ciuca, Ioana Mihaiela Oancea, Cristian Iacob, Daniela The Assessment of COVID-19 Pneumonia in Neonates: Observed by Lung Ultrasound Technique and Correlated with Biomarkers and Symptoms |
title | The Assessment of COVID-19 Pneumonia in Neonates: Observed by Lung Ultrasound Technique and Correlated with Biomarkers and Symptoms |
title_full | The Assessment of COVID-19 Pneumonia in Neonates: Observed by Lung Ultrasound Technique and Correlated with Biomarkers and Symptoms |
title_fullStr | The Assessment of COVID-19 Pneumonia in Neonates: Observed by Lung Ultrasound Technique and Correlated with Biomarkers and Symptoms |
title_full_unstemmed | The Assessment of COVID-19 Pneumonia in Neonates: Observed by Lung Ultrasound Technique and Correlated with Biomarkers and Symptoms |
title_short | The Assessment of COVID-19 Pneumonia in Neonates: Observed by Lung Ultrasound Technique and Correlated with Biomarkers and Symptoms |
title_sort | assessment of covid-19 pneumonia in neonates: observed by lung ultrasound technique and correlated with biomarkers and symptoms |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225555/ https://www.ncbi.nlm.nih.gov/pubmed/35743621 http://dx.doi.org/10.3390/jcm11123555 |
work_keys_str_mv | AT stoicescuemilrobert theassessmentofcovid19pneumoniainneonatesobservedbylungultrasoundtechniqueandcorrelatedwithbiomarkersandsymptoms AT manolescudianaluminita theassessmentofcovid19pneumoniainneonatesobservedbylungultrasoundtechniqueandcorrelatedwithbiomarkersandsymptoms AT iacobroxana theassessmentofcovid19pneumoniainneonatesobservedbylungultrasoundtechniqueandcorrelatedwithbiomarkersandsymptoms AT cerbusimona theassessmentofcovid19pneumoniainneonatesobservedbylungultrasoundtechniqueandcorrelatedwithbiomarkersandsymptoms AT dimamirabela theassessmentofcovid19pneumoniainneonatesobservedbylungultrasoundtechniqueandcorrelatedwithbiomarkersandsymptoms AT iacobemilradu theassessmentofcovid19pneumoniainneonatesobservedbylungultrasoundtechniqueandcorrelatedwithbiomarkersandsymptoms AT ciucaioanamihaiela theassessmentofcovid19pneumoniainneonatesobservedbylungultrasoundtechniqueandcorrelatedwithbiomarkersandsymptoms AT oanceacristian theassessmentofcovid19pneumoniainneonatesobservedbylungultrasoundtechniqueandcorrelatedwithbiomarkersandsymptoms AT iacobdaniela theassessmentofcovid19pneumoniainneonatesobservedbylungultrasoundtechniqueandcorrelatedwithbiomarkersandsymptoms AT stoicescuemilrobert assessmentofcovid19pneumoniainneonatesobservedbylungultrasoundtechniqueandcorrelatedwithbiomarkersandsymptoms AT manolescudianaluminita assessmentofcovid19pneumoniainneonatesobservedbylungultrasoundtechniqueandcorrelatedwithbiomarkersandsymptoms AT iacobroxana assessmentofcovid19pneumoniainneonatesobservedbylungultrasoundtechniqueandcorrelatedwithbiomarkersandsymptoms AT cerbusimona assessmentofcovid19pneumoniainneonatesobservedbylungultrasoundtechniqueandcorrelatedwithbiomarkersandsymptoms AT dimamirabela assessmentofcovid19pneumoniainneonatesobservedbylungultrasoundtechniqueandcorrelatedwithbiomarkersandsymptoms AT iacobemilradu assessmentofcovid19pneumoniainneonatesobservedbylungultrasoundtechniqueandcorrelatedwithbiomarkersandsymptoms AT ciucaioanamihaiela assessmentofcovid19pneumoniainneonatesobservedbylungultrasoundtechniqueandcorrelatedwithbiomarkersandsymptoms AT oanceacristian assessmentofcovid19pneumoniainneonatesobservedbylungultrasoundtechniqueandcorrelatedwithbiomarkersandsymptoms AT iacobdaniela assessmentofcovid19pneumoniainneonatesobservedbylungultrasoundtechniqueandcorrelatedwithbiomarkersandsymptoms |