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The Assessment of COVID-19 Pneumonia in Neonates: Observed by Lung Ultrasound Technique and Correlated with Biomarkers and Symptoms

Newborns infected with SARS-CoV2 infection develop different symptoms in comparison with adults, but one thing is clear: some of the most common manifestations include cough and other respiratory symptoms that need to be evaluated. In these cases, lung ultrasound is a useful imaging technique that c...

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Autores principales: Stoicescu, Emil Robert, Manolescu, Diana Luminita, Iacob, Roxana, Cerbu, Simona, Dima, Mirabela, Iacob, Emil Radu, Ciuca, Ioana Mihaiela, Oancea, Cristian, Iacob, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225555/
https://www.ncbi.nlm.nih.gov/pubmed/35743621
http://dx.doi.org/10.3390/jcm11123555
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author Stoicescu, Emil Robert
Manolescu, Diana Luminita
Iacob, Roxana
Cerbu, Simona
Dima, Mirabela
Iacob, Emil Radu
Ciuca, Ioana Mihaiela
Oancea, Cristian
Iacob, Daniela
author_facet Stoicescu, Emil Robert
Manolescu, Diana Luminita
Iacob, Roxana
Cerbu, Simona
Dima, Mirabela
Iacob, Emil Radu
Ciuca, Ioana Mihaiela
Oancea, Cristian
Iacob, Daniela
author_sort Stoicescu, Emil Robert
collection PubMed
description Newborns infected with SARS-CoV2 infection develop different symptoms in comparison with adults, but one thing is clear: some of the most common manifestations include cough and other respiratory symptoms that need to be evaluated. In these cases, lung ultrasound is a useful imaging technique that can evaluate the newborns’ lung damage caused by COVID-19 pneumonia and can be used for the surveillance of the patients as well, being non-irradiating and easy to use. Nineteen neonates who were confirmed as having SARS-CoV2 infection were investigated using this imaging tool, and the results were compared and correlated with their symptoms and biomarkers. The mean of LUSS was 12.21 ± 3.56 (S.D), while the 95% CI for the arithmetic mean was 10.49–13.93. The difference of an independent t-test between the LUSS for the patient who presented cough and the LUSS for the patient without cough was −4.48 with an associated p-value of p = 0.02. The Pearson’s correlation coefficient r = 0.89 (p = 0.03, 95% CI 0.0642 to 0.993) between the LUSS and IL-6 level showed a positive strong correlation. This reliable correlation between lung ultrasound score and inflammatory markers suggests that LUS could be used for monitoring inflammatory lung diseases in the future.
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spelling pubmed-92255552022-06-24 The Assessment of COVID-19 Pneumonia in Neonates: Observed by Lung Ultrasound Technique and Correlated with Biomarkers and Symptoms Stoicescu, Emil Robert Manolescu, Diana Luminita Iacob, Roxana Cerbu, Simona Dima, Mirabela Iacob, Emil Radu Ciuca, Ioana Mihaiela Oancea, Cristian Iacob, Daniela J Clin Med Article Newborns infected with SARS-CoV2 infection develop different symptoms in comparison with adults, but one thing is clear: some of the most common manifestations include cough and other respiratory symptoms that need to be evaluated. In these cases, lung ultrasound is a useful imaging technique that can evaluate the newborns’ lung damage caused by COVID-19 pneumonia and can be used for the surveillance of the patients as well, being non-irradiating and easy to use. Nineteen neonates who were confirmed as having SARS-CoV2 infection were investigated using this imaging tool, and the results were compared and correlated with their symptoms and biomarkers. The mean of LUSS was 12.21 ± 3.56 (S.D), while the 95% CI for the arithmetic mean was 10.49–13.93. The difference of an independent t-test between the LUSS for the patient who presented cough and the LUSS for the patient without cough was −4.48 with an associated p-value of p = 0.02. The Pearson’s correlation coefficient r = 0.89 (p = 0.03, 95% CI 0.0642 to 0.993) between the LUSS and IL-6 level showed a positive strong correlation. This reliable correlation between lung ultrasound score and inflammatory markers suggests that LUS could be used for monitoring inflammatory lung diseases in the future. MDPI 2022-06-20 /pmc/articles/PMC9225555/ /pubmed/35743621 http://dx.doi.org/10.3390/jcm11123555 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Stoicescu, Emil Robert
Manolescu, Diana Luminita
Iacob, Roxana
Cerbu, Simona
Dima, Mirabela
Iacob, Emil Radu
Ciuca, Ioana Mihaiela
Oancea, Cristian
Iacob, Daniela
The Assessment of COVID-19 Pneumonia in Neonates: Observed by Lung Ultrasound Technique and Correlated with Biomarkers and Symptoms
title The Assessment of COVID-19 Pneumonia in Neonates: Observed by Lung Ultrasound Technique and Correlated with Biomarkers and Symptoms
title_full The Assessment of COVID-19 Pneumonia in Neonates: Observed by Lung Ultrasound Technique and Correlated with Biomarkers and Symptoms
title_fullStr The Assessment of COVID-19 Pneumonia in Neonates: Observed by Lung Ultrasound Technique and Correlated with Biomarkers and Symptoms
title_full_unstemmed The Assessment of COVID-19 Pneumonia in Neonates: Observed by Lung Ultrasound Technique and Correlated with Biomarkers and Symptoms
title_short The Assessment of COVID-19 Pneumonia in Neonates: Observed by Lung Ultrasound Technique and Correlated with Biomarkers and Symptoms
title_sort assessment of covid-19 pneumonia in neonates: observed by lung ultrasound technique and correlated with biomarkers and symptoms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225555/
https://www.ncbi.nlm.nih.gov/pubmed/35743621
http://dx.doi.org/10.3390/jcm11123555
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