Human-Immune-System (HIS) humanized mouse model (DRAGA: HLA-A2.HLA-DR4.Rag1KO.IL-2RγcKO.NOD) for COVID-19

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We report a Human Immune System (HIS)-humanized mouse model (“DRAGA”: HLA-A2.HLA-DR4.Rag1KO.IL-2 RγcKO.NOD) for COVID-19 research. DRAGA mice express transgenically HLA-class I and class-II molecules in the mouse thymus to promote human T cell development and human B cell Ig-class switching. When in...

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Detalles Bibliográficos
Autores principales: Brumeanu, Teodor-D., Vir, Pooja, Karim, Ahmad Faisal, Kar, Swagata, Benetiene, Dalia, Lok, Megan, Greenhouse, Jack, Putmon-Taylor, Tammy, Kitajewski, Christopher, Chung, Kevin K., Pratt, Kathleen P., Casares, Sofia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Coronavirus – Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225593/
https://www.ncbi.nlm.nih.gov/pubmed/35348437
http://dx.doi.org/10.1080/21645515.2022.2048622
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